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المؤلفون: Agnès Poirier, Heidemarie Kletzl, Cordula Stillhart, Stephen Fowler, Kenichi Umehara, Andreas Guenther, Andreas Brink, Nicole A. Kratochwil, Dietrich Tuerck, Christophe Husser, Mark Savage, Mohammed Ullah, Lutz Mueller, Yumi Cleary, Katja Heinig
المصدر: Drug Metabolism and Disposition. 50:65-75
مصطلحات موضوعية: Pharmacology, Drug, Chemistry, In silico, media_common.quotation_subject, Pharmaceutical Science, Computational biology, Small molecule, Drug development, Pharmacokinetics, In vivo, Distribution (pharmacology), ADME, media_common
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a42eb9cb10d47b49d0cb86fb0a1206acTest
https://doi.org/10.1124/dmd.121.000563Test -
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المؤلفون: Michael Derks, Christoph Wandel, Sian Lennon-Chrimes, Axel Paehler, Piotr Szczesny, Heidemarie Kletzl, Lisa Squassante, Andreas Guenther
المصدر: Expert Opinion on Investigational Drugs. 30:893-901
مصطلحات موضوعية: Adult, Male, Vasopressin, Time Factors, Adolescent, Pyridines, medicine.drug_class, Administration, Oral, Biological Availability, Pharmacology, Benzodiazepines, Food-Drug Interactions, Young Adult, chemistry.chemical_compound, Double-Blind Method, Pharmacokinetics, Healthy volunteers, medicine, Humans, Tissue Distribution, Pharmacology (medical), Cross-Over Studies, Dose-Response Relationship, Drug, Chemistry, General Medicine, Middle Aged, Triazoles, Receptor antagonist, Bioavailability, Area Under Curve, Female, Penetrant (biochemical), Antidiuretic Hormone Receptor Antagonists, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594453fb8d9e29e6cd63b0245011308fTest
https://doi.org/10.1080/13543784.2021.1948009Test -
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المؤلفون: Fabian Model, Ludwig Kappos, Stephen L. Hauser, Heidemarie Kletzl, Ekaterina Gibiansky, Andreas Günther, Claire Petry, Ann Herman, Francois Mercier, Yumi Yamamoto, Qing Wang
المصدر: British Journal of Clinical Pharmacology
British journal of clinical pharmacology, vol 87, iss 6مصطلحات موضوعية: Phases of clinical research, Relapsing-Remitting, Neurodegenerative, 030226 pharmacology & pharmacy, Gastroenterology, 0302 clinical medicine, population analysis, Monoclonal, Medicine, Pharmacology (medical), 030212 general & internal medicine, Pharmacology & Pharmacy, Humanized, education.field_of_study, Pharmacology and Pharmaceutical Sciences, Multiple Sclerosis, Chronic Progressive, Chronic Progressive, Original Article, medicine.drug, medicine.medical_specialty, Multiple Sclerosis, pharmacokinetic-pharmacodynamic, Population, Primary Progressive Multiple Sclerosis, Antibodies, Monoclonal, Humanized, Autoimmune Disease, Antibodies, 03 medical and health sciences, Multiple Sclerosis, Relapsing-Remitting, Pharmacokinetics, Internal medicine, pharmacokinetic–pharmacodynamic, pharmacodynamics, Humans, Immunologic Factors, In patient, education, Pharmacology, business.industry, Multiple sclerosis, neurology, pharmacokinetic–, Neurosciences, Original Articles, medicine.disease, Brain Disorders, pharmacodynamic, Pharmacodynamics, Ocrelizumab, business
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8811580eb5543d689634ed86d7b68a05Test
http://europepmc.org/articles/PMC8247316Test -
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المؤلفون: Leon Aarons, Heidemarie Kletzl, Yumi Cleary, Michael Gertz, Andreas Günther, Katja Heinig, Aleksandra Galetin, Kayode Ogungbenro, Paul Grimsey
المصدر: Fukushima (Cleary), Y, Gertz, M, Grimsey, P, Günther, A, Heinig, K, Ogungbenro, K, Aarons, L, Galetin, A & Kletzl, H 2021, ' Model-based drug-drug interaction extrapolation strategy from adults to children – risdiplam in pediatric patients with spinal muscular atrophy ', Clinical Pharmacology & Therapeutics . https://doi.org/10.1002/cpt.2384Test
مصطلحات موضوعية: Adult, Male, Oncology, Physiologically based pharmacokinetic modelling, medicine.medical_specialty, Adolescent, CYP3A, Midazolam, Models, Biological, Muscular Atrophy, Spinal, Young Adult, Pharmacokinetics, In vivo, Internal medicine, Humans, Medicine, Drug Interactions, Pharmacology (medical), Child, Pharmacology, business.industry, Infant, Newborn, Area under the curve, Infant, Spinal muscular atrophy, SMA, medicine.disease, Pyrimidines, Neuromuscular Agents, Child, Preschool, Cytochrome P-450 CYP3A Inhibitors, Female, business, Azo Compounds, medicine.drug
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d9913e9af5e9910daa01792db02396Test
https://www.research.manchester.ac.uk/portal/en/publications/modelbased-drugdrug-interaction-extrapolation-strategy-from-adults-to-children--risdiplam-in-pediatric-patients-with-spinal-muscular-atrophyTest(c85742c4-c14d-419d-9311-c599b740e7f5).html -
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المؤلفون: Michael Derks (11145060), Sian Lennon-Chrimes (11145063), Andreas Guenther (33941), Lisa Squassante (5235881), Christoph Wandel (9316101), Piotr Szczesny (11145066), Axel Paehler (11145069), Heidemarie Kletzl (5557790)
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Neuroscience, Physiology, Pharmacology, Biotechnology, Immunology, Developmental Biology, Science Policy, Mental Health, Hematology, Virology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Balovaptan, vasopressin 1a, pharmacokinetics, bioavailability, healthy volunteers
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المؤلفون: Lauren Boak, Omar Khwaja, Daniel Umbricht, Christophe Grundschober, James T. McCracken, Eric Hollander, Heidemarie Kletzl, Lisa Squassante, Marta del Valle Rubido, Frederick Shic, Jana Noeldeke, Lawrence Scahill, Paulo Fontoura
المصدر: Neuropsychopharmacology
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Receptors, Vasopressin, Vasopressin, medicine.medical_specialty, Indoles, Adolescent, Autism Spectrum Disorder, medicine.drug_class, Pharmacology, High functioning, law.invention, Young Adult, 03 medical and health sciences, Cognition, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, medicine, Humans, Spiro Compounds, Psychiatry, Receptor, Psychotropic Drugs, Cross-Over Studies, Mechanism (biology), Communication, Middle Aged, medicine.disease, Receptor antagonist, Crossover study, Psychiatry and Mental health, Treatment Outcome, 030104 developmental biology, Social Perception, Autism spectrum disorder, Original Article, Corrigendum, Psychology, 030217 neurology & neurosurgery, Preliminary Data
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb3089c290e8c76df240cee68616bffTest
https://doi.org/10.1038/npp.2016.232Test -
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المؤلفون: Yumi Cleary, Katja Heinig, Lutz Müller, Hasane Ratni, Omar Khwaja, Nicolas Frances, Paul Jordan, Agnès Poirier, Birgit Jaber, Tobias Bergauer, Heidemarie Kletzl, Nada Al Kotbi, Stefan Sturm, Anne Marquet, Andreas Günther, Christian Czech, Nikhat Parkar
المصدر: British journal of clinical pharmacology. 85(1)
مصطلحات موضوعية: Adult, Male, Adolescent, CYP3A, Itraconazole, RNA Splicing, Administration, Oral, Pharmacology, Placebo, 030226 pharmacology & pharmacy, Muscular Atrophy, Spinal, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pharmacokinetics, Double-Blind Method, Medicine, Humans, Pharmacology (medical), Drug Interactions, 030212 general & internal medicine, RNA, Messenger, Volunteer, business.industry, Original Articles, Middle Aged, Confidence interval, Healthy Volunteers, Survival of Motor Neuron 2 Protein, Pyrimidines, Tolerability, Neuromuscular Agents, Pharmacodynamics, Area Under Curve, Cytochrome P-450 CYP3A Inhibitors, business, Azo Compounds, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a179691a66077906bc034e6725650dTest
https://pubmed.ncbi.nlm.nih.gov/30302786Test -
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المؤلفون: Norcross Roger, Moshe Finel, Nenad Manevski, Victor A. Iglesias, Marius C. Hoener, Dietrich Tuerck, Stephen Fowler, Paul Schmid, Olivia Spleiss, Heidemarie Kletzl
المصدر: Journal of Pharmacology and Experimental Therapeutics. 352:358-367
مصطلحات موضوعية: UGT1A4, Glucuronidation, Black People, Pharmacology, Biology, Polymorphism, Single Nucleotide, 030226 pharmacology & pharmacy, DNA sequencing, Substrate Specificity, law.invention, 03 medical and health sciences, Glucuronides, 0302 clinical medicine, Tandem Mass Spectrometry, law, Humans, Gene Silencing, Glucuronosyltransferase, Oxazoles, Cells, Cultured, Chromatography, High Pressure Liquid, 030304 developmental biology, Genetics, chemistry.chemical_classification, 0303 health sciences, Splice site mutation, 3. Good health, Enzyme, chemistry, Drug development, RNA splicing, Microsomes, Liver, Recombinant DNA, Molecular Medicine, Databases, Nucleic Acid
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8172f13f9cad04a04e634c848f42a827Test
https://doi.org/10.1124/jpet.114.220194Test -
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المؤلفون: Miriam Pein-Hackelbusch, Heidemarie Kletzl, Stefan Sturm, Peter Kühl, Laura Isabell Immohr, Andreas Günther, Angela Dischinger
المصدر: International journal of pharmaceutics. 530(1-2)
مصطلحات موضوعية: Adult, Male, Taste, Electronic tongue, Chemistry, Pharmaceutical, Pharmaceutical Science, 02 engineering and technology, Pharmacology, Oral cavity, 030226 pharmacology & pharmacy, Excipients, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Tongue, Medicine, Humans, Palatability, Electronic Nose, business.industry, Healthy subjects, 021001 nanoscience & nanotechnology, Pediatric drug, medicine.anatomical_structure, 0210 nano-technology, business, Oral retinoid, Cognitive psychology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9595a91512e275eeb1872b2a5679567Test
https://pubmed.ncbi.nlm.nih.gov/28750893Test -
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المؤلفون: Mark R. Nilges, Susanne Ostrowitzki, Heidemarie Kletzl, Susanne Schroeder, Taleen Hanania, Andreas Hoeflich, Bettina Holtmann, Will Spooren, Stefanie Saenger, Michael Sendtner, Friedrich Metzger
المصدر: Amyotrophic Lateral Sclerosis. 13:418-429
مصطلحات موضوعية: Male, Genetic enhancement, medicine.medical_treatment, Mice, Transgenic, Disease, Pharmacology, Severity of Illness Index, Mice, medicine, Animals, Dosing, Insulin-Like Growth Factor I, Amyotrophic lateral sclerosis, Motor Neurons, business.industry, Growth factor, Amyotrophic Lateral Sclerosis, General Medicine, Motor neuron, Spinal cord, medicine.disease, Motor coordination, Disease Models, Animal, medicine.anatomical_structure, Neurology, Disease Progression, Neurology (clinical), business, Neuroscience
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594b69f91bb97c330f6c18a2c72c4ac2Test
https://doi.org/10.3109/17482968.2012.679944Test