المؤلفون: Campo, G., Riggio, V.A., Cerutti, A., Ruffino, B., Panepinto, D., Zanetti, M.C.

المصدر: DESALINATION AND WATER TREATMENT ; volume 127, page 165-170

مصطلحات موضوعية: Pharmacology, Molecular Biology, General Medicine, Biochemistry

الإتاحة: https://doi.org/10.5004/dwt.2018.22995Test
https://www.deswater.com/DWT_articles/vol_127_papers/127_2018_165.pdfTest

المؤلفون: Aquila, G., Morciano, G., De Marco, D., Preti, D., Pedriali, G., Trapella, C., Campo, G., Rizzo, P., Pinton, P.

المصدر: Vascular Pharmacology ; volume 103-105, page 47 ; ISSN 1537-1891

مصطلحات موضوعية: Pharmacology, Molecular Medicine, Physiology

الإتاحة: https://doi.org/10.1016/j.vph.2017.12.003Test
https://api.elsevier.com/content/article/PII:S1537189117303713?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1537189117303713?httpAccept=text/plainTest

المؤلفون: Licastro, F., Chiappelli, M., Porcellini, E., Campo, G., Buscema, M., Grossi, E., Garoia, F., Ferrari, R.

المصدر: Current Pharmaceutical Design ; volume 16, issue 7, page 783-788 ; ISSN 1381-6128

مصطلحات موضوعية: Drug Discovery, Pharmacology

الإتاحة: https://doi.org/10.2174/138161210790883543Test
http://eurekaselect.com/article/download/71097Test

المؤلفون: Marciano MC, Calapai G, Campo G, Mazzaglia G, Cilia M, Rizzo A, Scuri R

المساهمون: Marciano, M, Calapai, G, Campo, G, Mazzaglia, G, Cilia, M, Rizzo, A, Scuri, R

مصطلحات موضوعية: Pharmacology, business.industry, Vitamin E, medicine.medical_treatment, medicine, Animal Model, medicine.disease, business, Reperfusion injury, Beneficial effects, Ischemia/Reperfusion

الوصف: Oxygen fret radicals have been implicated in ischemia/reperfusion injury (1). We investigated the effects of pretreatment with IRFI-016, a new antioxidant drug, that proved to have beneficial effects in myocardial &hernia (2), on levels of cerebral malonildialdehyde (a product of lipid peroxidation), mortality and hyperactivity following brain ischemia/reperfusion injury in the Mongolian gerbils. Brain ischemia/reperfusion injury was induced by 5 mm of bilateral occlusion of common carotid arteries followed by reperfusion, a procedure which causes hippocampal lesions in the gerbils (3). IRF!I-016 (50, 100 and 200 mglkg/i.p.), administered 30 min before occlusion, significantly reduced cerebral malondialdehyde formation, mortality and hyperactivity following global cerebral ischemia and reperfusion. Data indicate that IRFI-016 might be effective in improving ischemic cerebral damage.

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c0f99058434b8ffafcc0ab0c1ca46aTest
http://hdl.handle.net/10281/223737Test

المؤلفون: Calapai, G, Crupi, A, Firenzuoli, F, Costantino, G, Inferrera, G, Campo, G M, Caputi, A P

المصدر: Journal of Pharmacy and Pharmacology ; volume 51, issue 6, page 723-728 ; ISSN 0022-3573 2042-7158

مصطلحات موضوعية: Pharmaceutical Science, Pharmacology

الوصف: The plant Hypericum perforatum is used in folk medicine to treat several diseases and research attention has been recently focused on its antidepressant action. Hypericin and flavonoids are the most important constituents of the plant, but the exact role of these compounds in the effects of hypericum on mood disorders is not well known. We have investigated the contribution of these compounds to the antidepressant effects of hypericum. The effects of acute administration of hypericum extracts on levels of 5-hydroxytryptamine (5-HT), tryptophan, 5-hydroxyindoleacetic acid (5-HIAA), noradrenaline and dopamine in the cortex, diencephalon and brainstem was evaluated. The levels of these neurotransmitters were measured 1 h and 24 h after administration of two different extracts, one containing 0.3% hypericin and 6% flavonoids (Li 160; 25–500 mg kg−1), the other containing 0.3% hypericin and 50% flavonoids (Ph-50; 25–500 mg kg−1). Results from experiments performed on 5-HT turnover were compared with the effects of fluoxetine (10–80 mg kg−1). Li 160, Ph-50 and fluoxetine induced a significant increase in the 5-HT content of the cortex. In the diencephalon Ph-50, but not Li 160 or fluoxetine, elicited an increase in 5-HT and 5-HIAA levels. In the brainstem Ph-50 and fluoxetine caused an increase in 5-HT content; Li 160 did not change neurotransmitter content. Both Li 160 and Ph-50 caused increases of noradrenaline and dopamine in the diencephalon. In the brainstem only Ph-50 induced an increase in noradrenaline content. Our data confirm that acute administration of hypericum extracts modifies the levels of neurotransmitters involved in the pathophysiology of mood disorders. When the extracts contain a higher concentration of flavonoids the effects are more widespread and involve brain regions such as diencephalon and brainstem that are implicated in depression.

الإتاحة: https://doi.org/10.1211/0022357991772862Test
http://academic.oup.com/jpp/article-pdf/51/6/723/36785701/0022357991772862.pdfTest

المؤلفون: Spina, E., Gitto, C., Avenoso, A., Campo, G. M., Caputi, A. P., Perucca, E.

المصدر: European Journal of Clinical Pharmacology ; volume 51, issue 5, page 395-398 ; ISSN 0031-6970 1432-1041

مصطلحات موضوعية: Pharmacology (medical), Pharmacology, General Medicine

الإتاحة: https://doi.org/10.1007/s002280050220Test

المؤلفون: Altavilla, D., Squadrito, F., Ammendolia, L., Squadrito, G., Campo, G. M., Canale, P., Ioculano, M., Musolino, C., Alonci, A., Sardella, A., Urna, G., Saitta, A., Caputi, A. P.

المصدر: Inflammation Research ; volume 45, issue 8, page 398-404 ; ISSN 1023-3830 1420-908X

مصطلحات موضوعية: Pharmacology, Immunology

الإتاحة: https://doi.org/10.1007/bf02252935Test

المؤلفون: Squadrito, F., Saitta, A., Altavilla, D., Ioculano, M., Canale, P., Campo, G. M., Squadrito, G., Di Tano, G., Mazzu', A., Caputi, A. P.

المصدر: Inflammation Research ; volume 45, issue 1, page 14-19 ; ISSN 1023-3830 1420-908X

مصطلحات موضوعية: Pharmacology, Immunology

الإتاحة: https://doi.org/10.1007/bf02263499Test

المؤلفون: Spina, E., Avenoso, A., Campo, G. M., Caputi, A. P., Perucca, E.

المصدر: Psychopharmacology ; volume 117, issue 4, page 413-416 ; ISSN 0033-3158 1432-2072

مصطلحات موضوعية: Pharmacology

الإتاحة: https://doi.org/10.1007/bf02246212Test

المؤلفون: SQUADRITO, F, ALTAVILLA, D, CANALE, P, IOCULANO, M, AMMENDOLIA, L, CAMPO, G, CAPUTI, A

المصدر: Pharmacological Research ; volume 31, page 175-175 ; ISSN 1043-6618

مصطلحات موضوعية: Pharmacology

الإتاحة: https://doi.org/10.1016/1043-6618Test(95)86960-3
https://api.elsevier.com/content/article/PII:1043661895869603?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:1043661895869603?httpAccept=text/plainTest