التفاصيل البيبلوغرافية
| العنوان: |
Mathematical modeling of the glucagon challenge test |
| المؤلفون: |
Masroor, Saeed, van Dongen, Marloes G. J., Alvarez-Jimenez, Ricardo, Burggraaf, Koos, Peletier, Lambertus A., Peletier, Mark A. |
| المساهمون: |
Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
| المصدر: |
Journal of Pharmacokinetics and Pharmacodynamics ; volume 46, issue 6, page 553-564 ; ISSN 1567-567X 1573-8744 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2019 |
| مصطلحات موضوعية: |
Pharmacology |
| الوصف: |
A model for the homeostasis of glucose through the regulating hormones glucagon and insulin is described. It contains a subsystem that models the internalization of the glucagon receptor. Internalization is a mechanism in cell signaling, through which G-protein coupled receptors are taken from the surface of the cell to the endosome. The model is used to interpret data from a glucagon challenge test in which subjects have been under treatment with a novel glucagon receptor anti-sense drug which is aimed at reducing the number of receptors in the liver. It is shown how the receptor internalization results in tolerance of the blood glucose concentration to glucagon-induced hyperglycemia. We quantify the reduction of the number of receptors using the model and the data before and after treatment. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1007/s10928-019-09655-2 |
| DOI: |
10.1007/s10928-019-09655-2.pdf |
| DOI: |
10.1007/s10928-019-09655-2/fulltext.html |
| الإتاحة: |
https://doi.org/10.1007/s10928-019-09655-2Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.1854032C |
| قاعدة البيانات: |
BASE |
