نتائج البحث - "Pithavala, Yazdi K."

1

دورية أكاديمية

Evaluation of the Effect of Lorlatinib on CYP2B6, CYP2C9, UGT, and P-Glycoprotein Substrates in Patients with Advanced Non-Small Cell Lung Cancer.

المؤلفون: Chen, Joseph, Bearz, Alessandra, Kim, Dong-Wan, Mamdani, Hirva, Bauman, Jessica, Chiari, Rita, Ou, Sai-Hong Ignatius, Solomon, Benjamin J., Soo, Ross A., Felip, Enriqueta, Shaw, Alice T., Thurm, Holger, Clancy, Jill S., Lee, Kimberly, O'Gorman, Melissa, Tanski, Cherie, Pithavala, Yazdi K.

المصدر: Clinical Pharmacokinetics; Feb2024, Vol. 63 Issue 2, p171-182, 12p

مصطلحات موضوعية: ANAPLASTIC lymphoma kinase, NON-small-cell lung carcinoma, PHARMACOKINETICS, P-glycoprotein, PROTEIN-tyrosine kinase inhibitors, CYTOCHROME P-450

2

دورية أكاديمية

Evaluation of the absolute oral bioavailability of the anaplastic lymphoma kinase/c-ROS oncogene 1 kinase inhibitor lorlatinib in healthy participants.

المؤلفون: Hibma, Jennifer E., O'Gorman, Melissa, Nepal, Sunil, Pawlak, Sylvester, Ginman, Katherine, Pithavala, Yazdi K.

المصدر: Cancer Chemotherapy & Pharmacology; Jan2022, Vol. 89 Issue 1, p71-81, 11p

مصطلحات موضوعية: ANAPLASTIC lymphoma kinase, BIOAVAILABILITY, KINASE inhibitors, NON-small-cell lung carcinoma, PROTEIN-tyrosine kinase inhibitors, ONCOGENES

3

دورية أكاديمية

Phase 1 Study Evaluating the Effects of the Proton Pump Inhibitor Rabeprazole and Food on the Pharmacokinetics of Lorlatinib in Healthy Participants.

المؤلفون: Xu, Huiping, O'Gorman, Melissa T., Nepal, Sunil, James, Lee P., Ginman, Katherine, Pithavala, Yazdi K.

المصدر: Clinical Pharmacology in Drug Development; Nov2021, Vol. 10 Issue 11, p1395-1404, 10p

مصطلحات موضوعية: BIOAVAILABILITY, PROTON pump inhibitors, PHARMACOKINETICS, NON-small-cell lung carcinoma, ADVERSE health care events, MEALS, GASTRIC acid

4

دورية أكاديمية

The Effect of Modafinil on the Safety and Pharmacokinetics of Lorlatinib: A Phase I Study in Healthy Participants.

المؤلفون: Li, Jerry¹ (AUTHOR) Jerry.Li@Pfizer.com, Pithavala, Yazdi K.² (AUTHOR), Gong, Jason³ (AUTHOR), LaBadie, Robert R.⁴ (AUTHOR), Mfopou, Josué Kunjom⁵ (AUTHOR), Chen, Joseph² (AUTHOR)

المصدر: Clinical Pharmacokinetics. Oct2021, Vol. 60 Issue 10, p1303-1312. 10p.

مصطلحات موضوعية: *ANAPLASTIC lymphoma kinase, *MODAFINIL, *PROTEIN-tyrosine kinase inhibitors, *NON-small-cell lung carcinoma, *CYTOCHROME P-450, *PHARMACOKINETICS, *RITUXIMAB

5

دورية أكاديمية

Pharmacokinetics of Lorlatinib After Single and Multiple Dosing in Patients with Anaplastic Lymphoma Kinase (ALK)-Positive Non-Small Cell Lung Cancer: Results from a Global Phase I/II Study.

المؤلفون: Chen, Joseph, O'Gorman, Melissa T., James, Lee P., Klamerus, Karen J., Mugundu, Ganesh, Pithavala, Yazdi K.

المصدر: Clinical Pharmacokinetics; Oct2021, Vol. 60 Issue 10, p1313-1324, 12p

مصطلحات موضوعية: ANAPLASTIC lymphoma kinase, NON-small-cell lung carcinoma, PHARMACOKINETICS, CYTOCHROME P-450

6

دورية أكاديمية

Population pharmacokinetic model with time‐varying clearance for lorlatinib using pooled data from patients with non‐small cell lung cancer and healthy participants.

المؤلفون: Chen, Joseph, Houk, Brett, Pithavala, Yazdi K., Ruiz‐Garcia, Ana

المصدر: CPT: Pharmacometrics & Systems Pharmacology; Feb2021, Vol. 10 Issue 2, p148-160, 13p

مصطلحات موضوعية: NON-small-cell lung carcinoma, ANAPLASTIC lymphoma kinase, PROGNOSIS, PHARMACOKINETICS, PROTEIN-tyrosine kinases

النص الكامل

7

دورية أكاديمية

The effect of itraconazole on the pharmacokinetics of lorlatinib: results of a phase I, open-label, crossover study in healthy participants.

المؤلفون: Patel, Maulik, Chen, Joseph, McGrory, Stephanie, O'Gorman, Melissa, Nepal, Sunil, Ginman, Katherine, Pithavala, Yazdi K.

المصدر: Investigational New Drugs; Feb2020, Vol. 38 Issue 1, p131-139, 9p

مصطلحات موضوعية: ANTINEOPLASTIC agents, AMIDES, COMBINATION drug therapy, CLINICAL trials, CONFIDENCE intervals, CROSSOVER trials, DRUG interactions, DOSE-effect relationship in pharmacology, LUNG cancer, ORAL drug administration, PROTEIN-tyrosine kinase inhibitors, TREATMENT effectiveness, DESCRIPTIVE statistics, INVESTIGATIONAL drugs, ITRACONAZOLE, CYTOCHROME P-450, CHEMICAL inhibitors, PHARMACODYNAMICS

النص الكامل

8

دورية أكاديمية

The Effect of Rifampin on the Pharmacokinetics and Safety of Lorlatinib: Results of a Phase One, Open-Label, Crossover Study in Healthy Participants.

المؤلفون: Chen, Joseph, Xu, Huiping, Pawlak, Sylvester, James, Leonard P., Peltz, Gerson, Lee, Kimberly, Ginman, Katherine, Bergeron, Michelle, Pithavala, Yazdi K.

المصدر: Advances in Therapy; Feb2020, Vol. 37 Issue 2, p745-758, 14p

مصطلحات موضوعية: THERAPEUTIC use of antineoplastic agents, LUNG cancer, RESEARCH, HUMAN research subjects, RESEARCH methodology, LUNG tumors, PHARMACOKINETICS, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, DRUG interactions, RIFAMPIN, CROSSOVER trials, AMIDES

9

Population pharmacokinetic analysis of axitinib in healthy volunteers

المؤلفون: Garrett, May, Poland, Bill, Brennan, Meghan, Hee, Brian, Pithavala, Yazdi K, Amantea, Michael A

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::dda064ca6c77fa34b9eb1cb00ad02876Test
https://europepmc.org/articles/PMC3952722Test/

10

دورية أكاديمية

Lack of effect of smoking status on axitinib pharmacokinetics in patients with non-small-cell lung cancer.

المؤلفون: Garrett, May, Taylor, Timothy, Mould, Diane, Amantea, Michael, Chen, Ying, Ingrosso, Antonella, Pithavala, Yazdi, Mould, Diane R, Amantea, Michael A, Pithavala, Yazdi K

المصدر: Cancer Chemotherapy & Pharmacology; Dec2016, Vol. 78 Issue 6, p1131-1141, 11p

مصطلحات موضوعية: NON-small-cell lung carcinoma, DRUG efficacy, PHARMACOKINETICS, PROTEIN-tyrosine kinase inhibitors, VASCULAR endothelial growth factor receptors, TARGETED drug delivery, PATIENTS, BIOLOGICAL models, BIOTRANSFORMATION (Metabolism), HETEROCYCLIC compounds, IMIDAZOLES, LUNG cancer, LUNG tumors, SMOKING, PROTEIN kinase inhibitors

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