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المؤلفون: Agnès Poirier, Heidemarie Kletzl, Cordula Stillhart, Stephen Fowler, Kenichi Umehara, Andreas Guenther, Andreas Brink, Nicole A. Kratochwil, Dietrich Tuerck, Christophe Husser, Mark Savage, Mohammed Ullah, Lutz Mueller, Yumi Cleary, Katja Heinig
المصدر: Drug Metabolism and Disposition. 50:65-75
مصطلحات موضوعية: Pharmacology, Drug, Chemistry, In silico, media_common.quotation_subject, Pharmaceutical Science, Computational biology, Small molecule, Drug development, Pharmacokinetics, In vivo, Distribution (pharmacology), ADME, media_common
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a42eb9cb10d47b49d0cb86fb0a1206acTest
https://doi.org/10.1124/dmd.121.000563Test -
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المؤلفون: Michael Derks, Christoph Wandel, Sian Lennon-Chrimes, Axel Paehler, Piotr Szczesny, Heidemarie Kletzl, Lisa Squassante, Andreas Guenther
المصدر: Expert Opinion on Investigational Drugs. 30:893-901
مصطلحات موضوعية: Adult, Male, Vasopressin, Time Factors, Adolescent, Pyridines, medicine.drug_class, Administration, Oral, Biological Availability, Pharmacology, Benzodiazepines, Food-Drug Interactions, Young Adult, chemistry.chemical_compound, Double-Blind Method, Pharmacokinetics, Healthy volunteers, medicine, Humans, Tissue Distribution, Pharmacology (medical), Cross-Over Studies, Dose-Response Relationship, Drug, Chemistry, General Medicine, Middle Aged, Triazoles, Receptor antagonist, Bioavailability, Area Under Curve, Female, Penetrant (biochemical), Antidiuretic Hormone Receptor Antagonists, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594453fb8d9e29e6cd63b0245011308fTest
https://doi.org/10.1080/13543784.2021.1948009Test -
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المؤلفون: Fabian Model, Ludwig Kappos, Stephen L. Hauser, Heidemarie Kletzl, Ekaterina Gibiansky, Andreas Günther, Claire Petry, Ann Herman, Francois Mercier, Yumi Yamamoto, Qing Wang
المصدر: British Journal of Clinical Pharmacology
British journal of clinical pharmacology, vol 87, iss 6مصطلحات موضوعية: Phases of clinical research, Relapsing-Remitting, Neurodegenerative, 030226 pharmacology & pharmacy, Gastroenterology, 0302 clinical medicine, population analysis, Monoclonal, Medicine, Pharmacology (medical), 030212 general & internal medicine, Pharmacology & Pharmacy, Humanized, education.field_of_study, Pharmacology and Pharmaceutical Sciences, Multiple Sclerosis, Chronic Progressive, Chronic Progressive, Original Article, medicine.drug, medicine.medical_specialty, Multiple Sclerosis, pharmacokinetic-pharmacodynamic, Population, Primary Progressive Multiple Sclerosis, Antibodies, Monoclonal, Humanized, Autoimmune Disease, Antibodies, 03 medical and health sciences, Multiple Sclerosis, Relapsing-Remitting, Pharmacokinetics, Internal medicine, pharmacokinetic–pharmacodynamic, pharmacodynamics, Humans, Immunologic Factors, In patient, education, Pharmacology, business.industry, Multiple sclerosis, neurology, pharmacokinetic–, Neurosciences, Original Articles, medicine.disease, Brain Disorders, pharmacodynamic, Pharmacodynamics, Ocrelizumab, business
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8811580eb5543d689634ed86d7b68a05Test
http://europepmc.org/articles/PMC8247316Test -
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المؤلفون: Leon Aarons, Heidemarie Kletzl, Yumi Cleary, Michael Gertz, Andreas Günther, Katja Heinig, Aleksandra Galetin, Kayode Ogungbenro, Paul Grimsey
المصدر: Fukushima (Cleary), Y, Gertz, M, Grimsey, P, Günther, A, Heinig, K, Ogungbenro, K, Aarons, L, Galetin, A & Kletzl, H 2021, ' Model-based drug-drug interaction extrapolation strategy from adults to children – risdiplam in pediatric patients with spinal muscular atrophy ', Clinical Pharmacology & Therapeutics . https://doi.org/10.1002/cpt.2384Test
مصطلحات موضوعية: Adult, Male, Oncology, Physiologically based pharmacokinetic modelling, medicine.medical_specialty, Adolescent, CYP3A, Midazolam, Models, Biological, Muscular Atrophy, Spinal, Young Adult, Pharmacokinetics, In vivo, Internal medicine, Humans, Medicine, Drug Interactions, Pharmacology (medical), Child, Pharmacology, business.industry, Infant, Newborn, Area under the curve, Infant, Spinal muscular atrophy, SMA, medicine.disease, Pyrimidines, Neuromuscular Agents, Child, Preschool, Cytochrome P-450 CYP3A Inhibitors, Female, business, Azo Compounds, medicine.drug
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d9913e9af5e9910daa01792db02396Test
https://www.research.manchester.ac.uk/portal/en/publications/modelbased-drugdrug-interaction-extrapolation-strategy-from-adults-to-children--risdiplam-in-pediatric-patients-with-spinal-muscular-atrophyTest(c85742c4-c14d-419d-9311-c599b740e7f5).html -
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المؤلفون: Michael Derks (11145060), Sian Lennon-Chrimes (11145063), Andreas Guenther (33941), Lisa Squassante (5235881), Christoph Wandel (9316101), Piotr Szczesny (11145066), Axel Paehler (11145069), Heidemarie Kletzl (5557790)
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Neuroscience, Physiology, Pharmacology, Biotechnology, Immunology, Developmental Biology, Science Policy, Mental Health, Hematology, Virology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Balovaptan, vasopressin 1a, pharmacokinetics, bioavailability, healthy volunteers
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المؤلفون: Heidemarie Kletzl, A. Höflich, Friedrich Metzger, Eginhard Schick, Christoph Wandel, Norbert Bleich, C. Höflich, R.F. Staack, Andreas Guenther, Jan Frystyk
المصدر: Kletzl, H, Guenther, A, Höflich, A, Höflich, C, Frystyk, J, Staack, R F, Schick, E, Wandel, C, Bleich, N & Metzger, F 2017, ' First-in-man study with a novel PEGylated recombinant human insulin-like growth factor-I ', Growth Hormone & I G F Research, vol. 33, pp. 9-16 . https://doi.org/10.1016/j.ghir.2017.01.001Test
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Maximum Tolerated Dose, Erythema, Endocrinology, Diabetes and Metabolism, Hypoglycemia, Polyethylene Glycols, 03 medical and health sciences, Subcutaneous injection, 0302 clinical medicine, Endocrinology, Double-Blind Method, Pharmacokinetics, Internal medicine, medicine, Humans, Tissue Distribution, Insulin-Like Growth Factor I, Growth Substances, First-in-man study, Dose-Response Relationship, Drug, business.industry, Prognosis, medicine.disease, Recombinant Proteins, 030104 developmental biology, Tolerability, Pharmacodynamics, PEGylation, Female, medicine.symptom, business, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830323b68af1ea8d8ea70fdc93cf9300Test
https://doi.org/10.1016/j.ghir.2017.01.001Test -
7دورية أكاديمية
المؤلفون: Martin Czejka, Johannes Schüller, Heidemarie Kletzl
المصدر: Scientia Pharmaceutica; Volume 69; Issue 4; Pages: 289-297
مصطلحات موضوعية: amifostine, pharmacokinetics, drug interaction, cytostatics
وصف الملف: application/pdf
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المؤلفون: Yumi Cleary, Katja Heinig, Lutz Müller, Hasane Ratni, Omar Khwaja, Nicolas Frances, Paul Jordan, Agnès Poirier, Birgit Jaber, Tobias Bergauer, Heidemarie Kletzl, Nada Al Kotbi, Stefan Sturm, Anne Marquet, Andreas Günther, Christian Czech, Nikhat Parkar
المصدر: British journal of clinical pharmacology. 85(1)
مصطلحات موضوعية: Adult, Male, Adolescent, CYP3A, Itraconazole, RNA Splicing, Administration, Oral, Pharmacology, Placebo, 030226 pharmacology & pharmacy, Muscular Atrophy, Spinal, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pharmacokinetics, Double-Blind Method, Medicine, Humans, Pharmacology (medical), Drug Interactions, 030212 general & internal medicine, RNA, Messenger, Volunteer, business.industry, Original Articles, Middle Aged, Confidence interval, Healthy Volunteers, Survival of Motor Neuron 2 Protein, Pyrimidines, Tolerability, Neuromuscular Agents, Pharmacodynamics, Area Under Curve, Cytochrome P-450 CYP3A Inhibitors, business, Azo Compounds, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a179691a66077906bc034e6725650dTest
https://pubmed.ncbi.nlm.nih.gov/30302786Test -
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المؤلفون: L Servais, Ksenija Gorni, Janbernd Kirschner, Y. Cleary, Eugenio Mercuri, W. Yeung, Marianne Gerber, Craig Campbell, Nathalie Goemans, Heidemarie Kletzl, Jeppe Buchbjerg, Omar Khwaja, M Pera, Christian Czech, Giovanni Baranello
المصدر: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 46:S31
مصطلحات موضوعية: Oncology, medicine.medical_specialty, business.industry, Survival of motor neuron, General Medicine, SMN1, Spinal muscular atrophy, SMA, Placebo, medicine.disease, nervous system diseases, nervous system, Neurology, Tolerability, Pharmacokinetics, Internal medicine, medicine, Neurology (clinical), Adverse effect, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9a18015a9b40a6ff28a3f3702bb2b47dTest
https://doi.org/10.1017/cjn.2019.163Test -
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المؤلفون: John W. Day, Eugenio Mercuri, Nicolas Deconinck, L Servais, Heidemarie Kletzl, R. Masson, Marianne Gerber, Ksenija Gorni, Y. Cleary, C Cabalteja, Andrea Klein, T. Seabrook, M. El-Khairi, Basil T. Darras, Omar Khwaja, K. Gelblin, Christian Czech, Giovanni Baranello, C. Nguyen
المصدر: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 46:S31
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, business.industry, Survival of motor neuron, General Medicine, Spinal muscular atrophy, SMN1, 030105 genetics & heredity, SMA, Interim analysis, medicine.disease, Gastroenterology, Motor function, nervous system diseases, 03 medical and health sciences, 0302 clinical medicine, Neurology, Pharmacokinetics, Tolerability, Internal medicine, medicine, Neurology (clinical), business, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::193a4e5d38d8fcc2daf66d9496b47a16Test
https://doi.org/10.1017/cjn.2019.164Test