يعرض 1 - 7 نتائج من 7 نتيجة بحث عن '"Bear, Christine E."', وقت الاستعلام: 0.88s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Stage-Specific Generation of Human Pluripotent Stem Cell Derived Lung Models to Measure CFTR Function

    المؤلفون: Ngan, Shuk Yee, Quach, Henry T, Laselva, Onofrio, Huang, Elena N, Mangos, Maria, Xia, Sunny, Bear, Christine E, Wong, Amy P

    المساهمون: Ngan, Shuk Yee, Quach, Henry T, Laselva, Onofrio, Huang, Elena N, Mangos, Maria, Xia, Sunny, Bear, Christine E, Wong, Amy P

    مصطلحات موضوعية: cystic fibrosi, disease modeling, lung, personalized medicine, stem cell, Endoderm, Human, Reproducibility of Result, Cystic Fibrosis Transmembrane Conductance Regulator, Pluripotent Stem Cells

    العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35025140; volume:2; issue:1; firstpage:e341; journal:CURRENT PROTOCOLS; http://hdl.handle.net/11369/418210Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85123460734

    الإتاحة: https://doi.org/10.1002/cpz1.341Test
    http://hdl.handle.net/11369/418210Test

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  2. 2
    G) Show Robust Functional Rescue in Primary Nasal Cultures by Novel CFTR Modulators

    المؤلفون: Laselva, Onofrio, McCormack, Jacqueline, Bartlett, Claire, Ip, Wan, Gunawardena, Tarini N. A., Ouyang, Hong, Eckford, Paul D. W., Gonska, Tanja, Moraes, Theo J., Bear, Christine E.

    المصدر: Journal of Personalized Medicine
    Volume 10
    Issue 4

    مصطلحات موضوعية: cystic fibrosis, patient-derived nasal epithelial culture, novel modulators, c.3700A>, personalized medicine, CFTR, rare mutations, TRIKAFTA

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=multidiscipl::610f9cc92075dc3447014b5d9990bda2Test


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  3. 3
    دورية أكاديمية
    Preclinical Studies of a Rare CF-Causing Mutation in the Second Nucleotide Binding Domain (c.3700A>G) Show Robust Functional Rescue in Primary Nasal Cultures by Novel CFTR Modulators.

    المؤلفون: Laselva, Onofrio, McCormack, Jacqueline, Bartlett, Claire, Ip, Wan, Gunawardena, Tarini N. A., Ouyang, Hong, Eckford, Paul D. W., Gonska, Tanja, Moraes, Theo J., Bear, Christine E.

    المصدر: Journal of Personalized Medicine; Dec2020, Vol. 10 Issue 4, p209, 1p

    مصطلحات موضوعية: CYSTIC fibrosis transmembrane conductance regulator, CHLORIDE channels

    النص الكامل

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  4. 4
    دورية أكاديمية
    The CFTR Mutation c.3453G > C (D1152H) Confers an Anion Selectivity Defect in Primary Airway Tissue that Can be Rescued by Ivacaftor.

    المؤلفون: Laselva, Onofrio, Moraes, Theo J., He, Gengming, Bartlett, Claire, Szàrics, Ida, Ouyang, Hong, Gunawardena, Tarini N. A., Strug, Lisa, Bear, Christine E., Gonska, Tanja

    المصدر: Journal of Personalized Medicine; Jun2020, Vol. 10 Issue 2, p40, 1p

    مصطلحات موضوعية: CHLORIDE channels, CYSTIC fibrosis transmembrane conductance regulator, NASAL mucosa, CYSTIC fibrosis

    النص الكامل

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  5. 5
    دورية أكاديمية
    Functional rescue of c.3846G>A (W1282X) in patient-derived nasal cultures achieved by inhibition of nonsense mediated decay and protein modulators with complementary mechanisms of action.

    المؤلفون: Laselva, Onofrio1,2 (AUTHOR), Eckford, Paul DW1 (AUTHOR), Bartlett, Claire3 (AUTHOR), Ouyang, Hong3 (AUTHOR), Gunawardena, Tarini NA3 (AUTHOR), Gonska, Tanja3,4 (AUTHOR), Moraes, Theo J1,3,4 (AUTHOR) theo.moraes@sickkids.ca, Bear, Christine E1,2,5 (AUTHOR) bear@sickkids.ca

    المصدر: Journal of Cystic Fibrosis. Sep2020, Vol. 19 Issue 5, p717-727. 11p.

    مصطلحات موضوعية: *MUTANT proteins, *CYSTIC fibrosis transmembrane conductance regulator, *RECOMBINANT proteins, *SMALL molecules, *NONSENSE mutation

    مصطلحات جغرافية: GALAPAGOS Islands

    النص الكامل

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  6. 6
    رسالة جامعية
    Augmenting ORKAMBI® Rescue of F508del-CFTR Primary Respiratory Tissue with L-Arginine-Nitric Oxide Pathway Agonists

    المؤلفون: Wu, Yu-Sheng (Wilson)

    المساهمون: Bear, Christine E, Moraes, Theo, Physiology

    مصطلحات موضوعية: CFTR Modulators, Cystic Fibrosis, L-Arginine Nitric Oxide Pathway, Mucociliary Clearance, Personalized Medicine, Primary human respiratory epithelial cells

    الوقت: 0719

    وصف الملف: application/pdf

    العلاقة: http://hdl.handle.net/1807/102843Test

    الإتاحة: http://hdl.handle.net/1807/102843Test

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  7. 7
    رسالة جامعية
    Biochemical Interrogation of Rare Cystic Fibrosis Mutations Informs Strategies for Future Therapeutic Intervention

    المؤلفون: Molinski, Steven Victor

    المساهمون: Bear, Christine E, Biochemistry

    مصطلحات موضوعية: CFTR, Cystic Fibrosis, Drug Discovery, Personalized Medicine, Rare Mutations, Small Molecules

    الوقت: 0487

    العلاقة: http://hdl.handle.net/1807/77866Test

    الإتاحة: http://hdl.handle.net/1807/77866Test

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