دورية أكاديمية
Peripheral blood leukocyte populations and urinary neopterin during chemotherapy in patients with breast cancer
| العنوان: | Peripheral blood leukocyte populations and urinary neopterin during chemotherapy in patients with breast cancer |
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| المؤلفون: | Králíčková Pavlína, Vokurková Doris, Haviger Jiří, Řezáčová Vladimíra, Solichová Dagmar, Krčmová Lenka Kujovská, Melichar Bohuslav, Havlík Roman |
| المصدر: | Pteridines, Vol 27, Iss 3-4, Pp 67-75 (2016) |
| بيانات النشر: | De Gruyter, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Crystallography |
| مصطلحات موضوعية: | breast cancer, neopterin, peripheral blood lymphocytes, primary chemotherapy, Crystallography, QD901-999 |
| الوصف: | The aim of the present study was to investigate serial changes in urinary neopterin and the populations of peripheral blood lymphocytes in breast cancer patients treated with primary chemotherapy. Thirty patients with breast cancer, including 20 patients undergoing primary chemotherapy treated with the combination of doxorubicin and cyclophosphamide with sequential administration of paclitaxel-based therapy (cohort A), and 10 patients presenting for first-line therapy of metastatic disease and treated with the combination of bevacizumab, taxane and carboplatin (cohort M) were studied. Healthy female blood donors served as control group. Significant differences were observed in baseline relative and absolute counts of peripheral blood lymphocyte subpopulations between both patient cohorts and controls. Significant changes of peripheral blood lymphocyte subpopulations were also observed during the course of chemotherapy. However, no significant changes of urinary neopterin concentrations and no correlation between urinary neopterin and peripheral blood lymphocyte counts were observed. In conclusion, present data demonstrate the presence of significant differences in peripheral blood leukocyte phenotype in breast cancer patients even before the start of primary chemotherapy. Significant changes were observed during the course of chemotherapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0933-4807 2195-4720 |
| العلاقة: | https://doaj.org/toc/0933-4807Test; https://doaj.org/toc/2195-4720Test |
| DOI: | 10.1515/pterid-2016-0005 |
| الوصول الحر: | https://doaj.org/article/7490b2c5877444b8af9a83c8dba4dfe7Test |
| رقم الانضمام: | edsdoj.7490b2c5877444b8af9a83c8dba4dfe7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09334807 21954720 |
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| DOI: | 10.1515/pterid-2016-0005 |