دورية أكاديمية
Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study
العنوان: | Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study |
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المؤلفون: | María Angeles Vaz Salgado, Julie Earl, Victor Rodriguez Berrocal, Freddy Salge Arrieta, Ana Gomez, Juan Manuel Sepulveda-Sanchez, Ángel Perez-Nuñez, Elena Corral de la Fuente, Daniel Lourido, MaríaVillamayor, Hector Pian, Alfonso Muriel, Elisabetta Rossi, Rita Zamarchi, Alfredo Carrato, Luis Ley |
المصدر: | Future Science OA, Vol 8, Iss 5 (2022) |
بيانات النشر: | Future Science Ltd |
سنة النشر: | 2022 |
المجموعة: | Directory of Open Access Journals: DOAJ Articles |
مصطلحات موضوعية: | biomarker, circulating endothelial cells (CECs), glioblastoma, perfusion MRI, Medicine, Medicine (General), R5-920 |
الوصف: | Aim: Glioblastoma (GB) is an aggressive tumor type and the detection of circulating endothelial cells (CECs) in peripheral blood has been related to angiogenesis. Materials & methods: A prospective single-center pilot study of CEC detection at diagnosis in 22 patients with GB was performed, using the US FDA-approved CellSearch system. Results: A CEC cutoff value was estimated using a receiver operating curve (ROC) and patients were classified into two groups: <40 CEC/4 ml and >40 CEC/4 ml blood. Median overall survival was 25.33 months for group 1 and 8.23 months for group 2 cases (p = 0.02). There was no correlation between CEC and PWI (perfusion-weighted imaging) RM. Conclusion: CEC detection has a prognostic value in GB cases at diagnosis. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
تدمد: | 2056-5623 |
العلاقة: | https://doaj.org/toc/2056-5623Test; https://doaj.org/article/10cbeb6d83ca4bf8842cb0bb7fc1e6a4Test |
DOI: | 10.2144/fsoa-2022-0008 |
الإتاحة: | https://doi.org/10.2144/fsoa-2022-0008Test https://doaj.org/article/10cbeb6d83ca4bf8842cb0bb7fc1e6a4Test |
رقم الانضمام: | edsbas.400F10AF |
قاعدة البيانات: | BASE |
تدمد: | 20565623 |
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DOI: | 10.2144/fsoa-2022-0008 |