دورية أكاديمية
Iodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects.
| العنوان: | Iodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects. |
|---|---|
| المؤلفون: | Soriguer, Federico, Gutiérrez-Repiso, Carolina, Rubio-Martin, Elehazara, Linares, Francisca, Cardona, Isabel, López-Ojeda, Jaime, Pacheco, Marta, González-Romero, Stella, Garriga, Maria J., Velasco, Ines, Santiago, Piedad, García-Fuentes, Eduardo |
| المساهمون: | Soriguer,F, González-Romero,S, García-Fuentes,E Servicio de Endocrinología y Nutrición, Hospital Regional Universitario Carlos Haya, Málaga, Spain. Soriguer,F, Rubio-Martin,E CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Málaga, Spain. Gutiérrez-Repiso,C, Linares,F, Cardona,I, García-Fuentes,E Fundación IMABIS, Málaga, Spain. López-Ojeda,J, Pacheco, M Servicio de Radiología, Hospital Regional Universitario Carlos Haya, Málaga, Spain. Garriga, MJ Servicio de Análisis Clínicos, Hospital Regional Universitario Carlos Haya, Málaga, Spain. Velasco,I Servicio de Obstetricia y Ginecología, Hospital de Riotinto, Huelva, Spain. Santiago,P Servicio de Endocrinología y Nutrición, Hospital General, Jaen, Spain. García-Fuentes,E CIBER Fisiopaptología de la Obesidad y Nutrición (CIBERobn), Málaga, Spain. Laboratorio de Investigación, Málaga, Spain., The present study was supported in part by grants from the Instituto de Salud Carlos III (CP04/00133). CIBER FisiopatologÍa de la Obesidad y NutriciÓn (CIBEROBN) and CIBER de Diabetes y Enfermedades MetabÓlicas Asociadas (CIBERDEM)are ISCIII projects. |
| بيانات النشر: | Cambridge University Press |
| سنة النشر: | 2011 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Iodine, Thyroid function, Urinary iodine, Antioxidants, Mujeres Embarazadas, Adulto, Marcadores biológicos, Estrés Oxidativo, Inflamación, Proteínas de fase aguda, Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Halogens::Iodine, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants, Medical Subject Headings::Named Groups::Persons::Women::Pregnant Women, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers, Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Acute-Phase Proteins |
| الوصف: | Little information is available as to whether doses of iodide similar to those recommended in clinical practice for the prevention of iodine deficiency in pregnant women affect thyroid function. The aim of the present study was to analyse whether doses of iodide can affect thyroid function in adults, and evaluate its effect on plasma markers of oxidative stress, inflammation and acute-phase proteins. A total of thirty healthy volunteers (ten men and twenty women) with normal thyroid function were randomly assigned to three groups (n 10). Each group received a daily dose of 100, 200 or 300 μg of iodide in the form of KI for 6 months. Free tetraiodothyronine (FT4) levels at day 60 of the study were higher in the groups treated with 200 and 300 μg (P = 0·01), and correlated with the increase in urinary iodine (r 0·50, P = 0·007). This correlation lost its significance after adjustment for the baseline FT4. The baseline urinary iodine and FT4 correlated positively with the baseline glutathione peroxidase. On day 60, urinary iodine correlated with C-reactive protein (r 0·461, P = 0·018), and free triiodothyronine correlated with IL-6 (r - 0·429, P = 0·025). On day 60, the changes produced in urinary iodine correlated significantly with the changes produced in α1-antitrypsin (r 0·475, P = 0·014) and ceruloplasmin (r 0·599, P = 0·001). The changes in thyroid-stimulating hormone correlated significantly with the changes in α1-antitrypsin (r - 0·521, P = 0·005) and ceruloplasmin (r - 0·459, P = 0·016). In conclusion, the administration of an iodide supplement between 100 and 300 μg/d did not modify thyroid function in a population with adequate iodine intake. The results also showed a slight anti-inflammatory and antioxidative action of iodide. ; Yes |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0007-1145 1475-2662 |
| العلاقة: | http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8286421&fulltextType=RA&fileId=S0007114510005568Test; Soriguer F, Gutiérrez-Repiso C, Rubio-Martin E, Linares F, Cardona I, López-Ojeda J, et al. Iodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects. Br J Nutr. 2011;105 (12):1783-90.; http://hdl.handle.net/10668/1210Test |
| DOI: | 10.1017/S0007114510005568 |
| الإتاحة: | https://doi.org/10.1017/S0007114510005568Test http://hdl.handle.net/10668/1210Test |
| حقوق: | open access |
| رقم الانضمام: | edsbas.765C328D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00071145 14752662 |
|---|---|
| DOI: | 10.1017/S0007114510005568 |