دورية أكاديمية
Synthesis of cyclopentapeptides and cycloheptapeptides by DEPBT and the influence of some factors on cyclization
| العنوان: | Synthesis of cyclopentapeptides and cycloheptapeptides by DEPBT and the influence of some factors on cyclization |
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| المؤلفون: | Tang, YC, Xie, HB, Tian, GL, Ye, YH |
| المساهمون: | Ye, YH (reprint author), Peking Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China., Peking Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China., Hosp Sick Children, Toronto, ON M5G 1X8, Canada. |
| المصدر: | SCI |
| بيانات النشر: | journal of peptide research |
| سنة النشر: | 2002 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | coupling reagent, cyclic peptide, cyclization, DEPBT, linear peptide precursor, PEPTIDES, PENTAPEPTIDE, ANTAGONISTS |
| الوصف: | Three cyclic peptides - cyclo(GlyAlaTyrLeuAla), cyclo(GlyProTyrLeuAla) and cyclo(GlyTyrGlyGlyProPhePro) isolated and identified from medicinal herbs were chosen as model cyclic peptides to study the influence of the linear precursors and coupling reagents on cyclization. The 17 linear precursors of these three cyclic peptides were synthesized and cyclized using 3-(diethoxyphosphoryloxy)-(1-3)-benzotriazin-4 (3H)-one (DEPBT) as the major coupling reagent. The present work shows that: (i) the effects of linear peptide precursors on the cyclization are complex but some guidelines for choosing suitable precursor for cyclization could be considered; and (ii) DEPBT results in a higher cyclization yield compared with other coupling reagents. In addition, it was confirmed that peptides containing alternating D and L residues favor cyclization. ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000177120000004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Test ; Biochemical Research Methods ; Biochemistry & Molecular Biology ; SCI(E) ; 32 ; ARTICLE ; 2 ; 95-103 ; 60 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1397-002X |
| العلاقة: | JOURNAL OF PEPTIDE RESEARCH.2002,60,(2),95-103.; 762726; http://hdl.handle.net/20.500.11897/208796Test; WOS:000177120000004 |
| DOI: | 10.1034/j.1399-3011.2002.201000.x |
| الإتاحة: | https://doi.org/20.500.11897/208796Test https://doi.org/10.1034/j.1399-3011.2002.201000.xTest https://hdl.handle.net/20.500.11897/208796Test |
| رقم الانضمام: | edsbas.C27283E0 |
| قاعدة البيانات: | BASE |
| تدمد: | 1397002X |
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| DOI: | 10.1034/j.1399-3011.2002.201000.x |