دورية أكاديمية
Peptide Drug Conjugates and Their Role in Cancer Therapy
| العنوان: | Peptide Drug Conjugates and Their Role in Cancer Therapy |
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| المؤلفون: | Ethan Heh, Jesse Allen, Fabiola Ramirez, Daniel Lovasz, Lorena Fernandez, Tanis Hogg, Hannah Riva, Nathan Holland, Jessica Chacon |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 1, p 829 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | peptide-drug conjugates, bioconjugates, payload, linker, carrier, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Drug conjugates have become a significant focus of research in the field of targeted medicine for cancer treatments. Peptide-drug conjugates (PDCs), a subset of drug conjugates, are composed of carrier peptides ranging from 5 to 30 amino acid residues, toxic payloads, and linkers that connect the payload to the peptide. PDCs are further broken down into cell-penetrating peptides (CPPs) and cell-targeting peptides (CTPs), each having their own differences in the delivery of cytotoxic payloads. Generally, PDCs as compared to other drug conjugates—like antibody-drug conjugates (ADCs)—have advantages in tumor penetration, ease of synthesis and cost, and reduced off-target effects. Further, as compared to traditional cancer treatments (e.g., chemotherapy and radiation), PDCs have higher specificity for the target cancer with generally less toxic side effects in smaller doses. However, PDCs can have disadvantages such as poor stability and rapid renal clearance due to their smaller size and limited oral bioavailability due to digestion of its peptide structure. Some of these challenges can be overcome with modifications, and despite drawbacks, the intrinsic small size of PDCs with high target specificity still makes them an attractive area of research for cancer treatments. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/24/1/829Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms24010829 |
| الوصول الحر: | https://doaj.org/article/07916c55d6f3453d93e16b9645cbf762Test |
| رقم الانضمام: | edsdoj.07916c55d6f3453d93e16b9645cbf762 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms24010829 |