دورية أكاديمية
Virulence factors of the Mycobacterium tuberculosis complex
| العنوان: | Virulence factors of the Mycobacterium tuberculosis complex |
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| المؤلفون: | Forrellad, Marina Andrea, Klepp, Laura Ines, Gioffre, Andrea, Sabio y Garcia, Julia Veronica, Morbidoni, Hector R., Santangelo, María De La Paz, Cataldi, Angel Adrian, Bigi, Fabiana |
| المصدر: | Virulence 4 (1) : 3-66 (2013) |
| بيانات النشر: | Taylor & Francis |
| سنة النشر: | 2013 |
| المجموعة: | Inta Digital (ID - Instituto Nacional de Tecnología Agropecuaria) |
| مصطلحات موضوعية: | Mycobacterium tuberculosis, Virulencia, Patogenicidad, Control de Enfermedades, Vacuna, Virulence, Pathogenicity, Disease Control, Vaccines |
| الوصف: | The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world. ; Instituto de Biotecnología ; Fil: Forrellad, Marina Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina ; Fil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina ; Fil: Gioffre, Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina ; Fil: Sabio y Garcia, Julia Veronica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina ; Fil: Morbidoni, Hector R. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Cátedra de Microbiología; Argentina ; Fil: Santangelo, María De La Paz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. ; Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina ; Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2150-5594 2150-5608 |
| العلاقة: | http://hdl.handle.net/20.500.12123/4293Test; https://doi.org/10.4161/viru.22329Test |
| DOI: | 10.4161/viru.22329 |
| الإتاحة: | https://doi.org/20.500.12123/4293Test https://doi.org/10.4161/viru.22329Test https://hdl.handle.net/20.500.12123/4293Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6C708DB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21505594 21505608 |
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| DOI: | 10.4161/viru.22329 |