التفاصيل البيبلوغرافية
| العنوان: |
Positive correlation between pigment epithelium-derived factor and monocyte chemoattractant protein-1 levels in the aqueous humour of patients with uveitis. |
| المؤلفون: |
Yoshida, Yumiko, Yamagishi, Sho-ichi, Matsui, Takanori, Nakamura, Kazuo, Imaizumi, Tsutomu, Yoshimura, Koichi, Yamakawa, Ryoji |
| المصدر: |
British Journal of Ophthalmology; Jun2007, Vol. 91 Issue 6, p737-738, 2p, 1 Graph |
| مصطلحات موضوعية: |
EPITHELIUM, MONOCYTES, PROTEINS, UVEITIS, PATIENTS, CATARACT, CRYSTALLINE lens diseases |
| مستخلص: |
Aim: To evaluate whether aqueous humour levels of pigment epithelium-derived factor (PEDF) are associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis. Methods: Aqueous humour levels of MCP-1 and PEDF were determined by EUSA in 34 uveitis samples and 9 cataract control samples. Results: Aqueous humour MCP-1 and PEDF levels were significantly higher in patients with infectious or non-infectious uveitis than in controls (mean (SD) 32.3 (10.7) ng/ml vs 4.48 (1.10) ng/ml vs 0.47 (0.10) ng/ml, and 8.40 (1.30) ng/ml vs 5.01 (0.92) μg/ml vs 1.32 (0.22) μg/ml, respectively, p<0.001). A positive correlation between PEDF and MCP-1 was found in patients with uveitis (r = 0.39, p<0.01 ). Conclusion: The results demonstrated that aqueous humour levels of PEDF were positively associated with MCP-1 in patients with uveitis. The present observations suggest that aqueous humour levels of PEDF may be a marker of inflammation in uveitis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
