التفاصيل البيبلوغرافية
| العنوان: |
Effects of cardiac growth on electrical dyssynchrony in the single ventricle patient. |
| المؤلفون: |
Tikenoğulları, O. Z.1 (AUTHOR), Peirlinck, M.2 (AUTHOR), Chubb, H.3 (AUTHOR), Dubin, A. M.3 (AUTHOR), Kuhl, E.1 (AUTHOR), Marsden, A. L.1,3,4,5 (AUTHOR) amarsden@stanford.edu |
| المصدر: |
Computer Methods in Biomechanics & Biomedical Engineering. Jun2024, Vol. 27 Issue 8, p1011-1027. 17p. |
| مصطلحات موضوعية: |
*PATIENT-ventilator dyssynchrony, *HYPOPLASTIC left heart syndrome, *FINITE element method, *CARDIAC surgery |
| مستخلص: |
Single ventricle patients, including those with hypoplastic left heart syndrome (HLHS), typically undergo three palliative heart surgeries culminating in the Fontan procedure. HLHS is associated with high rates of morbidity and mortality, and many patients develop arrhythmias, electrical dyssynchrony, and eventually ventricular failure. However, the correlation between ventricular enlargement and electrical dysfunction in HLHS physiology remains poorly understood. Here we characterize the relationship between growth and electrophysiology in HLHS using computational modeling. We integrate a personalized finite element model, a volumetric growth model, and a personalized electrophysiology model to perform controlled in silico experiments. We show that right ventricle enlargement negatively affects QRS duration and interventricular dyssynchrony. Conversely, left ventricle enlargement can partially compensate for this dyssynchrony. These findings have potential implications on our understanding of the origins of electrical dyssynchrony and, ultimately, the treatment of HLHS patients. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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