التفاصيل البيبلوغرافية
| العنوان: |
Immune checkpoint inhibitor toxicities: systems-based approaches to improve patient care and research. |
| المؤلفون: |
Johnson, Douglas B1 (AUTHOR), Reynolds, Kerry L2 (AUTHOR), Sullivan, Ryan J2 (AUTHOR), Balko, Justin M1 (AUTHOR), Patrinely, James R3 (AUTHOR), Cappelli, Laura C4 (AUTHOR), Naidoo, Jarushka5 (AUTHOR), Moslehi, Javid J1 (AUTHOR) |
| المصدر: |
Lancet Oncology. Aug2020, Vol. 21 Issue 8, pe398-e404. 7p. |
| مصطلحات موضوعية: |
*MEDICAL care, *PATIENTS, *RESEARCH funding, *TUMORS, *PATIENT education, *ONCOLOGY |
| مستخلص: |
Immune checkpoint inhibitors (ICIs) have now been approved in numerous and diverse cancer types and combination regimens. Effective recognition and treatment of ICI toxicities, which might occur acutely, affect any organ system, and produce many distinct clinical syndromes, have emerged as essential goals of ICI management. Thus, developing robust diagnostic and management approaches for ICI toxicity across the health-care system is an urgent and unmet clinical need. In this Personal View, we describe barriers to high-quality care that have constrained the most effective management of patients with cancer receiving ICI treatment. We review education initiatives to enhance patient and physician awareness, which is necessary given the broad spectrum of ICI toxicities often experienced by patients, and assess various systems-based approaches that maximise the chances of appropriate management. In addition, we describe research pipelines that broaden evidence-based approaches and the pathobiology of these novel events. Developing effective, systematic approaches for the recognition and treatment of ICI toxicities will continue to grow in importance as these agents proliferate in cancer care. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
