التفاصيل البيبلوغرافية
| العنوان: |
Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation. |
| المؤلفون: |
Best, J Adam, Blair, David A, Knell, Jamie, Yang, Edward, Mayya, Viveka, Doedens, Andrew, Dustin, Michael L, Goldrath, Ananda W, Monach, Paul, Shinton, Susan A, Hardy, Richard R, Jianu, Radu, Koller, David, Collins, Jim, Gazit, Roi, Garrison, Brian S, Rossi, Derrick J, Narayan, Kavitha, Sylvia, Katelyn, Kang, Joonsoo |
| المصدر: |
Nature Immunology; Apr2013, Vol. 14 Issue 4, p404-412, 9p, 1 Diagram, 5 Graphs |
| مصطلحات موضوعية: |
GENETIC transcription, CD8 antigen, T cells, INFECTION, CELL differentiation, GENE expression, PATHOGENIC microorganisms |
| مستخلص: |
After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putative transcriptional regulators. Notably, we found that the expression of key gene signatures can be used to predict the memory-precursor potential of CD8+ effector cells. Long-lived memory CD8+ cells ultimately expressed a small subset of genes shared by natural killer T and γδ T cells. Although distinct inflammatory milieu and T cell precursor frequencies influenced the differentiation of CD8+ effector and memory populations, core transcriptional signatures were regulated similarly, whether polyclonal or transgenic, and whether responding to bacterial or viral model pathogens. Our results provide insights into the transcriptional regulation that influence memory formation and CD8+ T cell immunity. [ABSTRACT FROM AUTHOR] |
|
Copyright of Nature Immunology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
