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المؤلفون: Sonja Stölzle-Feix, Nadine Becker, Alison Obergrussberger, Andrea Brüggemann, Clemens Möller, Niels Fertig
المصدر: Channels
مصطلحات موضوعية: Patch-Clamp Techniques, Biophysics, Quantitative Structure-Activity Relationship, Nanotechnology, cardiomyocytes, Review, Biochemistry, Ion, Cell membrane, Small Molecule Libraries, action potential, Automated patch clamp, safety pharmacology, Drug Discovery, medicine, Potassium Channel Blockers, Animals, Humans, Patch clamp, Integral membrane protein, Ion channel, Chemistry, screening, ion channels, temperature, High-Throughput Screening Assays, Electrophysiology, medicine.anatomical_structure, impedance, Flux (metabolism), Sodium Channel Blockers
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2d55d35260852adabdde2d95a3d964Test
http://europepmc.org/articles/PMC4850050Test -
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المؤلفون: Yuji Haraguchi, Tatsuya Shimizu, Takayuki Oka, Atsushi Ohtsuki
المصدر: BMC Pharmacology & Toxicology
مصطلحات موضوعية: ERG1 Potassium Channel, Patch-Clamp Techniques, hERG, CHO Cells, Pharmacology, Membrane Potentials, Cricetulus, Automated patch clamp, Cricetinae, Potassium Channel Blockers, medicine, Animals, Humans, Pharmacology (medical), Channel blocker, Patch clamp, Dose-Response Relationship, Drug, biology, Chinese hamster ovary cell, HEK 293 cells, High-throughput screening, Reproducibility of Results, Potassium channel blocker, hERG channel, Ether-A-Go-Go Potassium Channels, High-Throughput Screening Assays, Electrophysiology, HEK293 Cells, Technical Advance, Drug development, biology.protein, Automated patch-clamp, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d81b52253edccb6f3c2ce00b476b3bTest
https://doi.org/10.1186/s40360-015-0042-9Test -
3
المؤلفون: Jun Chen, Tianbo Li, Jane L. Grogan, Eugene Y. Chiang, Tania Chernov-Rogan, Gang Lu
المصدر: PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0180154 (2017)مصطلحات موضوعية: 0301 basic medicine, Patch-Clamp Techniques, Computer science, Physiology, T-Lymphocytes, Cell Membranes, Drug Evaluation, Preclinical, lcsh:Medicine, Gene Expression, Biochemistry, Ion Channels, Sodium Channels, Membrane Potentials, NAV1.5 Voltage-Gated Sodium Channel, White Blood Cells, 0302 clinical medicine, Mathematical and Statistical Techniques, Automated patch clamp, Animal Cells, Medicine and Health Sciences, NAV1.3 Voltage-Gated Sodium Channel, Transgenes, NAV1.4 Voltage-Gated Sodium Channel, lcsh:Science, Throughput (business), Membrane Electrophysiology, Membrane potential, Multidisciplinary, Kv1.3 Potassium Channel, NAV1.2 Voltage-Gated Sodium Channel, Drug discovery, T Cells, Physics, NAV1.7 Voltage-Gated Sodium Channel, Potassium channel, Curve Fitting, Electrophysiology, Bioassays and Physiological Analysis, Physical Sciences, Cellular Types, Cellular Structures and Organelles, Computer hardware, Research Article, Sodium Channel Blockers, Immune Cells, Immunology, Materials Science, Material Properties, Primary Cell Culture, Biophysics, Antigen-Presenting Cells, Neurophysiology, Capacitance, CHO Cells, Research and Analysis Methods, Membrane Potential, 03 medical and health sciences, Cricetulus, Potassium Channel Blockers, Animals, Patch clamp, Ion channel, Blood Cells, Voltage-gated ion channel, business.industry, Sodium channel, lcsh:R, Electrophysiological Techniques, Biology and Life Sciences, Proteins, Cell Biology, High-Throughput Screening Assays, Rats, NAV1.1 Voltage-Gated Sodium Channel, 030104 developmental biology, NAV1.6 Voltage-Gated Sodium Channel, lcsh:Q, business, Patch Clamp Techniques, Mathematical Functions, 030217 neurology & neurosurgery, Neuroscience
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0a4dea24fb7238ad043c6591c71b59Test
http://europepmc.org/articles/PMC5500279Test -
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المؤلفون: WeaverC. David, J KadakiaRishin, L OlsenMichelle, BanerjeeSreedatta, S SmithStephen, S DentonJerod, RaphemotRene, DaysEmily
المصدر: ASSAY and Drug Development Technologies. 11:532-543
مصطلحات موضوعية: Patch-Clamp Techniques, Drug Evaluation, Preclinical, Neurotransmission, Pharmacology, Rats, Sprague-Dawley, Automated patch clamp, Drug Discovery, Potassium Channel Blockers, medicine, Animals, Humans, Original ArticlesIon Channel Focus, Patch clamp, Potassium Channels, Inwardly Rectifying, Cells, Cultured, Inward-rectifier potassium ion channel, Chemistry, HEK 293 cells, Potassium channel blocker, Molecular Pharmacology, Flow Cytometry, Small molecule, Rats, HEK293 Cells, Spectrometry, Fluorescence, Astrocytes, Flow Injection Analysis, Biophysics, Molecular Medicine, Ion Channel Gating, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bf33c3689dd64a799a53c6caf4b607Test
https://doi.org/10.1089/adt.2013.544Test -
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المصدر: Journal of Pharmacological and Toxicological Methods. 67:33-44
مصطلحات موضوعية: ERG1 Potassium Channel, congenital, hereditary, and neonatal diseases and abnormalities, Patch-Clamp Techniques, hERG, Population, CHO Cells, Pharmacology, Toxicology, Cricetulus, Automated patch clamp, Cricetinae, Potassium Channel Blockers, Barracuda, medicine, Animals, Humans, cardiovascular diseases, Patch clamp, education, Ion channel, education.field_of_study, Dose-Response Relationship, Drug, biology, Chemistry, Potassium channel blocker, biology.organism_classification, Ether-A-Go-Go Potassium Channels, Potassium channel, High-Throughput Screening Assays, biology.protein, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8b16dddcf75bcf6aea1ff5e8dbcb18Test
https://doi.org/10.1016/j.vascn.2012.10.002Test -
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المؤلفون: Vinoj George, Hugh Russell, Andrew Staniforth, Divya Rajamohan, Xuebin Yang, Spandan Kalra, Minh Duc Hoang, Chris Denning
المصدر: Stem Cells and Development
مصطلحات موضوعية: 0301 basic medicine, Pluripotent Stem Cells, Patch-Clamp Techniques, Cellular differentiation, Cell, Primary Cell Culture, Action Potentials, 030204 cardiovascular system & hematology, Biology, 03 medical and health sciences, 0302 clinical medicine, Automated patch clamp, medicine, Potassium Channel Blockers, Technical Note, Humans, Myocytes, Cardiac, Patch clamp, Induced pluripotent stem cell, Cells, Cultured, HEK 293 cells, Sodium, Cell Differentiation, Cell Biology, Hematology, R1, Cell biology, High-Throughput Screening Assays, Electrophysiology, 030104 developmental biology, medicine.anatomical_structure, Cell culture, Potassium, Calcium, Developmental Biology, Sodium Channel Blockers
وصف الملف: application/pdf; PDF
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4997bd843b6e095b9bddb2b3f3e8f9f8Test
https://pubmed.ncbi.nlm.nih.gov/26906236Test -
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المؤلفون: Terry Bridal, Michael Margulis, Steve Sorota, Michael Donio, Xin Wang
المصدر: ASSAY and Drug Development Technologies. 8:755-765
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Patch-Clamp Techniques, hERG, Drug Evaluation, Preclinical, chemistry.chemical_element, Pharmacology, Membrane Potentials, Automated patch clamp, Drug Discovery, High-Throughput Screening Assays, Potassium Channel Blockers, Humans, cardiovascular diseases, Patch clamp, Thallium, Cells, Cultured, biology, Drug discovery, Ether-A-Go-Go Potassium Channels, Potassium channel, HEK293 Cells, chemistry, Luminescent Measurements, biology.protein, Molecular Medicine, Plate reader
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331efac129dc36779158a7f730fc205dTest
https://doi.org/10.1089/adt.2010.0267Test -
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المؤلفون: A. Peter Johnson, Soren Wacker, Jean-Francois Rolland, Erik Lindahl, David Madge, Colin W. G. Fishwick, Bert L. de Groot, Katie J. Simmons, Wiktor Jurkowski
المصدر: Chemmedchem
ChemMedChemمصطلحات موضوعية: Nervous system, Patch-Clamp Techniques, 1-1, Pharmacology, Biochemistry, Membrane Potentials, Automation, 0302 clinical medicine, Automated patch clamp, Cricetinae, Drug Discovery, Kv1.2 Potassium Channel, hERG, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, biology, Chemistry, Full Papers, Potassium channel, Biofysik, 3. Good health, Molecular Docking Simulation, KCNA2, medicine.anatomical_structure, Molecular Medicine, medicine.drug, drug design, Biophysics, CHO Cells, Small Molecule Libraries, 03 medical and health sciences, Cricetulus, medicine, Potassium Channel Blockers, Animals, Patch clamp, 030304 developmental biology, Kv1.1 Potassium Channel, Virtual screening, Binding Sites, Kv1.1–1.2(3), Organic Chemistry, Potassium channel blocker, virtual screening, High-Throughput Screening Assays, Protein Structure, Tertiary, ROC Curve, nervous system, biology.protein, Kv1, 2(3), 030217 neurology & neurosurgery
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4729ca45890946b76bb95c04c3fb171Test
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-103761Test -
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المؤلفون: Herbert Himmel, Thomas Knott, Gesa Rascher-Eggstein, Olaf Scheel
المصدر: Assay and drug development technologies. 9(6)
مصطلحات موضوعية: Automation, Laboratory, Patch-Clamp Techniques, Computer science, business.industry, Voltage clamp, Action Potentials, Modular design, Automation, Ether-A-Go-Go Potassium Channels, HEK293 Cells, Automated patch clamp, Drug Discovery, Potassium Channel Blockers, Molecular Medicine, Humans, Patch clamp, business, Throughput (business), Ion channel, Computer hardware, Software, Communication channel
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc7e71f70072d66587e7f7e5f92863dTest
https://pubmed.ncbi.nlm.nih.gov/21675869Test -
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المؤلفون: Lisa M. Shyjka, Elena S. Trepakova, Hope D. Erickson, Serguei S. Sidach, Jessica C. Brimecombe, Antonio E. Lacerda, Mary C. Kochan, Glenn E. Kirsch, Arthur M. Brown
المصدر: Journal of pharmacological and toxicological methods. 50(2)
مصطلحات موضوعية: Drug, ERG1 Potassium Channel, Patch-Clamp Techniques, media_common.quotation_subject, Long QT syndrome, hERG, Drug Evaluation, Preclinical, Pharmacology, Toxicology, Transfection, Inhibitory Concentration 50, Automated patch clamp, medicine, Potassium Channel Blockers, Potency, Humans, Patch clamp, Cells, Cultured, media_common, biology, Chemistry, Temperature, Reproducibility of Results, medicine.disease, Potassium channel, Electric Stimulation, Ether-A-Go-Go Potassium Channels, Pharmaceutical Preparations, Potassium Channels, Voltage-Gated, biology.protein
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a559d613201c50da1777e739545e8171Test
https://pubmed.ncbi.nlm.nih.gov/15385083Test