Aqueous Extract of Taegeuk Ginseng Inhibits Platelet Aggregation and Thrombus Formation
| العنوان: | Aqueous Extract of Taegeuk Ginseng Inhibits Platelet Aggregation and Thrombus Formation |
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| المؤلفون: | Muhammad Irfan, Jae-Ho Do, Man Hee Rhee, Jung Jin Rho, Kwangseung Lee, Jungwon Gwak, Dong Chung Kim |
| المصدر: | Journal of Medicinal Food. 21:1137-1144 |
| بيانات النشر: | Mary Ann Liebert Inc, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Platelet Aggregation, Panax, Medicine (miscellaneous), Pharmacology, Antithrombins, Rats, Sprague-Dawley, 03 medical and health sciences, Ginseng, 0302 clinical medicine, In vivo, Oral administration, Antithrombotic, medicine, Animals, Humans, Thrombus, Blood Coagulation, Nutrition and Dietetics, Plant Extracts, Chemistry, Thrombosis, medicine.disease, Adenosine, 030104 developmental biology, Coagulation, 030220 oncology & carcinogenesis, Platelet Aggregation Inhibitors, Ex vivo, medicine.drug |
| الوصف: | The inhibitory effects of taegeuk ginseng extract (TGE) on platelet aggregation and thrombus formation were investigated. The TGE significantly inhibited collagen- and adenosine 5'-diphosphate (ADP)-induced platelet aggregation in vitro in a dose-dependent manner. Also oral administration of TGE to rats significantly prevented ADP- and collagen-induced platelet aggregation ex vivo, but it did not affect the plasma coagulation system. The oral administration of TGE significantly delayed the occlusion of the carotid artery in ferrous chloride-treated rats in vivo. These results suggest that in vivo antithrombotic effect of TGE may be due to its inhibitory activity on platelet aggregation rather than on plasma coagulation. |
| تدمد: | 1557-7600 1096-620X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19812c0ff0477e1da5e64b31c03b334Test https://doi.org/10.1089/jmf.2017.4145Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d19812c0ff0477e1da5e64b31c03b334 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577600 1096620X |
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