دورية أكاديمية
CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas.
| العنوان: | CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas. |
|---|---|
| المؤلفون: | Pita, Jaime Miguel, Raspé, Eric, Coulonval, Katia, Decaussin-Petrucci, Myriam, Tarabichi, Maxime, Dom, Geneviève, Libert, Frédérick, Ruscas-Craciun, Ligia Ioana, Andry, Guy, Wicquart, Laurence, Leteurtre, Emmanuelle, Tresallet, Christophe, Marlow, Laura A, Copland, John A, Durante, Cosimo, Maenhaut, Carine, Cavaco, Branca Maria, Dumont, Jacques Emile, Costante, Giuseppe, Roger, Pierre P. |
| المصدر: | Frontiers in endocrinology, 14 |
| سنة النشر: | 2023 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Sciences bio-médicales et agricoles, ATC, CDK4 Thr172-phosphorylation, PDTC, biomarkers, dabrafenib, palbociclib, trametinib |
| الوصف: | CDK4/6 inhibitors (CDK4/6i) have been established as standard treatment against advanced Estrogen Receptor-positive breast cancers. These drugs are being tested against several cancers, including in combinations with other therapies. We identified the T172-phosphorylation of CDK4 as the step determining its activity, retinoblastoma protein (RB) inactivation, cell cycle commitment and sensitivity to CDK4/6i. Poorly differentiated (PDTC) and anaplastic (ATC) thyroid carcinomas, the latter considered one of the most lethal human malignancies, represent major clinical challenges. Several molecular evidence suggest that CDK4/6i could be considered for treating these advanced thyroid cancers. ; SCOPUS: ar.j ; info:eu-repo/semantics/published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| العلاقة: | uri/info:doi/10.3389/fendo.2023.1247542; uri/info:pmid/37964967; uri/info:scp/85176430803; uri/info:pmcid/PMC10641312; https://dipot.ulb.ac.be/dspace/bitstream/2013/365060/3/Pita_Fendo-14-1247542.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/365060Test |
| الإتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/365060Test https://dipot.ulb.ac.be/dspace/bitstream/2013/365060/3/Pita_Fendo-14-1247542.pdfTest |
| رقم الانضمام: | edsbas.F3F9DA80 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |