التفاصيل البيبلوغرافية
| العنوان: |
Paeonol assists fluconazole and amphotericin B to inhibit virulence factors and pathogenicity of Candida albicans |
| المؤلفون: |
Min Pan (102325), Qirui Wang (11140919), Ting Cheng (1692172), Daqiang Wu (352408), Tianming Wang (761422), Guiming Yan (7235252), Jing Shao (216596) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Medicine, Pharmacology, Immunology, Cancer, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Candida albicans, virulence factors, hypha, paeonol, sensitizer, Galleria mellonella |
| الوصف: |
This study aimed to evaluate the mono- and dual- antifungal activities of paeonol (PAE) and fluconazole (FLZ)/amphotericin B (AmB). To this end, the effects of PAE and FLZ/AmB on cell surface hydrophobicity, hydrolase activity, morphological transition were investigated in vitro and in a Galleria mellonella infection model. The results showed a relatively high minimum inhibitory concentration (MIC) and sessile MIC (SMIC) of PAE alone. However, compared with the single drug, the combined use of PAE and FLZ/AmB had a potent synergistic potential to inhibit the virulence factors for Candida . The concomitant use of two drugs was consistently more effective than either drug alone for increasing survival rate, decreasing the fungal burden, and alleviating the pathological features of G. mellonella infected by the fungus. Taken together, these findings demonstrate the anti- Candida effects of PAE plus FLZ/AmB and their potential to increase the sensitivity of C. albicans to FLZ/AmB of PAE. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Paeonol_assists_fluconazole_and_amphotericin_B_to_inhibit_virulence_factors_and_pathogenicity_of_i_Candida_albicans_i_/16755666Test |
| DOI: |
10.6084/m9.figshare.16755666.v1 |
| الإتاحة: |
https://doi.org/10.6084/m9.figshare.16755666.v1Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.964F8687 |
| قاعدة البيانات: |
BASE |
