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المصدر: Redox Biology
Redox Biology, Vol 34, Iss, Pp 101547-(2020)مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Trypanosoma brucei brucei, Respiratory chain, Trypanothione, Mitochondrion, Trypanosoma brucei, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Animals, roGFP2, lcsh:QH301-705.5, Tryparedoxin, lcsh:R5-920, biology, Chemistry, Organic Chemistry, Peroxiredoxin, Hydrogen Peroxide, Peroxiredoxins, biology.organism_classification, Leishmania, Cell biology, Mitochondria, 030104 developmental biology, lcsh:Biology (General), Mitochondrial matrix, biology.protein, lcsh:Medicine (General), Oxidation-Reduction, 030217 neurology & neurosurgery, Peroxidase, Research Paper
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb87a1c2b2ac9e8f9b919245ad5d62dTest
http://europepmc.org/articles/PMC7218024Test -
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المصدر: eLife
eLife, Vol 9 (2020)مصطلحات موضوعية: Eflornithine, QH301-705.5, Spermidine, Science, Green Fluorescent Proteins, Trypanosoma brucei brucei, trypanothione, Trypanothione, Biosensing Techniques, Oxidative phosphorylation, Mitochondrion, Trypanosoma brucei, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Thioredoxins, Biosynthesis, Biochemistry and Chemical Biology, Oxidoreductase, parasitic diseases, Homeostasis, Biology (General), chemistry.chemical_classification, Microbiology and Infectious Disease, General Immunology and Microbiology, biology, thiol redox metabolism, General Neuroscience, Hydrogen Peroxide, General Medicine, biology.organism_classification, Glutathione, Trypanocidal Agents, Mitochondria, Oxidative Stress, Cytosol, chemistry, Biochemistry, Mitochondrial matrix, Medicine, Other, Oxidation-Reduction, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90efc61debb8f402a6756c72d82772fTest
https://doi.org/10.7554/elife.53227Test -
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المؤلفون: Elke Brodbeck-Persch, Steve Bryson, François Diederich, Raoul De Gasparo, R. Luise Krauth-Siegel, Marcel Kaiser, Emil F. Pai, Nina B. Hentzen
المصدر: ChemMedChem. 13:957-967
مصطلحات موضوعية: Models, Molecular, Trypanosoma, Pyrrolidines, Glutathione reductase, Trypanothione, Crystallography, X-Ray, Ligands, 010402 general chemistry, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Non-competitive inhibition, Parasitic Sensitivity Tests, parasitic diseases, Drug Discovery, NADH, NADPH Oxidoreductases, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Binding site, Pharmacology, chemistry.chemical_classification, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Active site, Oxidoreductase inhibitor, biology.organism_classification, Trypanocidal Agents, 0104 chemical sciences, Enzyme, Solubility, biology.protein, Molecular Medicine, Oxidation-Reduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565b0d4285fe4da01f36bc25c7ecfc1bTest
https://doi.org/10.1002/cmdc.201800067Test -
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المؤلفون: Mariana Bonilla, Marcelo A. Comini, Matías Deambrosi, Haike Antelmann, Natalie Dirdjaja, Yasar Luqman Ahmed, Lorenz Adrian, Ursula Jakob, Rachel B. Currier, Alejandro E. Leroux, Kathrin Ulrich, R. Luise Krauth-Siegel
المساهمون: Currier R., Ulrich K., Leroux A., Dirdjaja N., Deambrosi Borrat Matías, Instituto Pasteur (Montevideo)., Bonilla Chao Mariana Magdalena, Instituto Pasteur (Montevideo)., Luqman Ahmed Y., Adrian L., Antelmann H., Jakob U., Comini Marcelo A., Instituto Pasteur (Montevideo)., Krauth-Siegel R.L.
المصدر: PLoS Pathogens
COLIBRI
Universidad de la República
instacron:Universidad de la República
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Pathogens, Vol 15, Iss 9, p e1008065 (2019)مصطلحات موضوعية: Genes, Protozoan, Mutant, Protozoan Proteins, Mitochondrion, Biochemistry, purl.org/becyt/ford/1 [https], Thioredoxins, RNA interference, Medicine and Health Sciences, chaperone, Trypanosoma brucei, Biology (General), Amino Acids, Energy-Producing Organelles, Protozoans, 0303 health sciences, biology, Organic Compounds, Chemistry, Eukaryota, Recombinant Proteins, Enzymes, Mitochondria, Cell biology, Nucleic acids, Genetic interference, Gene Knockdown Techniques, Physical Sciences, purl.org/becyt/ford/3 [https], Epigenetics, Cellular Structures and Organelles, Thioredoxin, Oxidoreductases, Oxidation-Reduction, Luciferase, Research Article, Trypanosoma, QH301-705.5, Trypanosoma brucei brucei, Immunology, Bioenergetics, Trypanosome, Microbiology, Redox, Mitochondrial Proteins, purl.org/becyt/ford/3.3 [https], 03 medical and health sciences, Virology, Trypanosoma Brucei, Parasitic Diseases, Genetics, Animals, Humans, Sulfur Containing Amino Acids, Cysteine, purl.org/becyt/ford/1.6 [https], Molecular Biology, 030304 developmental biology, 500 Naturwissenschaften und Mathematik::570 Biowissenschaften, Biologie::579 Mikroorganismen, Pilze, Algen, 030306 microbiology, Organic Chemistry, Organisms, Chemical Compounds, Wild type, Biology and Life Sciences, Proteins, Cell Biology, RC581-607, biology.organism_classification, Parasitic Protozoans, Oxidation-reduction, Chaperone (protein), Mutation, Enzymology, biology.protein, RNA, Parasitology, Gene expression, Immunologic diseases. Allergy, Molecular Chaperones, Trypanosoma Brucei Gambiense
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1479757250d326147bf104a57ad754d5Test
https://doi.org/10.1371/journal.ppat.1008065Test -
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المؤلفون: Mariana Bonilla, Blessing Musunda, Kathrin Ulrich, Marcelo A. Comini, Bruno Manta, Natalie Dirdjaja, Samantha Ebersoll, R. Luise Krauth-Siegel, Torsten Schmenger
المصدر: Redox Biology
Redox Biology, Vol 15, Iss C, Pp 532-547 (2018)مصطلحات موضوعية: 0301 basic medicine, Hot Temperature, cTXNPx, cytosolic 2-Cys-peroxiredoxin, Mitochondrial intermembrane space, Clinical Biochemistry, Mutant, 2-ME, 2-mercaptoethanol, Glutaredoxin, Respiratory chain, Mitochondrion, PC, procyclic, Biochemistry, SKO, single knockout, Mice, Adenosine Triphosphate, Cytosol, HED, (hydroxyethyl)disulfide, Catalytic Domain, GR, glutathione reductase, Trypanosoma brucei, lcsh:QH301-705.5, lcsh:R5-920, IMS, intermembrane space, Tpx, tryparedoxin, biology, Chemistry, Glutaredoxin 2, ASCT, acetate:succinate-CoA-transferase, tet, tetracycline, Adaptation, Physiological, Cell biology, Mitochondria, RNAi, RNA interference, Grx, glutaredoxin, Mitochondrial Membranes, lcsh:Medicine (General), Oxidation-Reduction, Research Paper, TCEP, tris(2-carboxyethyl)phosphine, Trypanosoma brucei brucei, Trypanothione, T. brucei, Trypanosoma brucei, 03 medical and health sciences, BS, bloodstream, T(SH)2, trypanothione, AMS, 4-acetamido-4′-maleimidylstilbene-2,2′-disulfonic acid, Animals, Humans, WT, wildtype, Alleles, Glutaredoxins, S. cerevisiae, Saccharomyces cerevisiae, Tryparedoxin, Cell Proliferation, T. cruzi, Trypanosoma cruzi, KO, knockout, Organic Chemistry, Wild type, biology.organism_classification, LipDH, lipoamide dehydrogenase, mTXNPx, mitochondrial 2-Cys-peroxiredoxin, 030104 developmental biology, Trypanosomiasis, African, lcsh:Biology (General), Mutation, MM(PEG)12, methyl-PEG12-maleimide, TS2, trypanothione disulfide, Gsp, glutathionylspermidine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490bedc8d4e89f6b7978482cb58866a2Test
https://pubmed.ncbi.nlm.nih.gov/29413965Test -
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المصدر: Biological Chemistry. 396:445-463
مصطلحات موضوعية: biology, Mechanism (biology), Clinical Biochemistry, Trypanothione, Oxidative phosphorylation, medicine.disease_cause, biology.organism_classification, Biochemistry, Cell biology, Oxidative Stress, chemistry.chemical_compound, chemistry, Drug development, medicine, Trypanosoma, Animals, Signal transduction, Reactive Oxygen Species, Oxidation-Reduction, Molecular Biology, Oxidative stress, Signal Transduction, Cysteine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b8dc09678bd92727fd67b3e77a012eTest
https://doi.org/10.1515/hsz-2014-0279Test -
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المؤلفون: Annika Wagner, R. Luise Krauth-Siegel, Erika Diehl, Ute A. Hellmich
المصدر: Biomolecular NMR assignments. 11(2)
مصطلحات موضوعية: 0301 basic medicine, Trypanosoma, Amino Acid Motifs, Trypanosoma brucei, Biochemistry, Redox, 03 medical and health sciences, Thioredoxins, Structural Biology, Oxidoreductase, Nuclear Magnetic Resonance, Biomolecular, chemistry.chemical_classification, 030102 biochemistry & molecular biology, biology, Active site, Hydrogen Peroxide, biology.organism_classification, 030104 developmental biology, Drug development, chemistry, Cytoplasm, biology.protein, Thioredoxin, Oxidation-Reduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c379d18be360f57d4a99b181ac56541Test
https://pubmed.ncbi.nlm.nih.gov/28573456Test -
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المؤلفون: Alejandro E. Leroux, R. Luise Krauth-Siegel, Marcel Kaiser, Michael Adams, Mouhssin Oufir, Reto Brun, Matthias Hamburger, Katja Becker, Stefanie Zimmermann
المصدر: BIOORGANIC & MEDICINAL CHEMISTRY
مصطلحات موضوعية: Clinical Biochemistry, Trypanosoma brucei brucei, Trypanothione, Protozoan Proteins, Pharmaceutical Science, Trypanosoma brucei, Ornithine Decarboxylase, 01 natural sciences, Biochemistry, Dithiothreitol, Ornithine decarboxylase, 03 medical and health sciences, chemistry.chemical_compound, Lactones, Amide Synthases, Drug Discovery, Humans, NADH, NADPH Oxidoreductases, Sulfhydryl Compounds, Molecular Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Metabolism, Glutathione, Ornithine Decarboxylase Inhibitors, biology.organism_classification, Cynaropicrin, 0104 chemical sciences, Enzyme Activation, Enzyme, Trypanosomiasis, African, Molecular Medicine, Oxidation-Reduction, Sesquiterpenes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d285b21649536e3fb86c6dfc1c90ecTest
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المؤلفون: Alejandro E. Leroux, R. Luise Krauth-Siegel
المصدر: Antioxidants & Redox Signaling. 17:583-607
مصطلحات موضوعية: Physiology, Antiparasitic, medicine.drug_class, Clinical Biochemistry, Trypanothione, Ascorbic Acid, Biology, Biochemistry, Antioxidants, chemistry.chemical_compound, medicine, Animals, Parasites, Cysteine, Molecular Biology, Cysteine metabolism, General Environmental Science, Entamoeba, Cell Biology, Glutathione, Leishmania, biology.organism_classification, Ascorbic acid, Molecular Weight, chemistry, General Earth and Planetary Sciences, Oxidation-Reduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8af4a36ff283822df784098dc37cf5Test
https://doi.org/10.1089/ars.2011.4392Test -
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المؤلفون: Alejandro E. Leroux, R. Luise Krauth-Siegel
المصدر: Molecular and biochemical parasitology. 206(1-2)
مصطلحات موضوعية: 0301 basic medicine, Chagas disease, Trypanosoma, Trypanothione, Antiprotozoal Agents, Protozoan Proteins, Gene Expression, Biology, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Biosynthesis, Amide Synthases, Detoxification, medicine, Animals, Chagas Disease, NADH, NADPH Oxidoreductases, Molecular Targeted Therapy, Sulfhydryl Compounds, Enzyme Inhibitors, Molecular Biology, Leishmaniasis, chemistry.chemical_classification, Leishmania, medicine.disease, biology.organism_classification, High-Throughput Screening Assays, 030104 developmental biology, Enzyme, Trypanosomiasis, African, chemistry, Biochemistry, Parasitology, Oxidation-Reduction, DNA
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf5150294bb9e321e4f0921797b4145Test
https://pubmed.ncbi.nlm.nih.gov/26592324Test
