Human papilloma virus genotypes in dysplasia and epithelial hyperplasia of oral cavity using the luminex xmap technology. A multicenter study
| العنوان: | Human papilloma virus genotypes in dysplasia and epithelial hyperplasia of oral cavity using the luminex xmap technology. A multicenter study |
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| المؤلفون: | Martha Rebolledo, María Rosa Buenahora, Fabio Ancisar Aristizabal, David Díaz-Báez, Carlos M Ardila, Farith González-Martínez, Carlos Humberto Colegial, Efrain Alvarez, Sandra Janeth Perdomo-Lara, Jairo Bustillo, Alvaro Horta, Gloria Inés Lafaurie |
| المساهمون: | Lafaurie, Gloria Ines [0000-0003-3986-0625], Perdomo Lara, Sandra Janneth [0000-0002-4429-3760], Díaz-Báez, David [0000-0001-8890-6250] |
| المصدر: | Perdomo-Lara, Sandra Janeth ; Buenahora, María Rosa ; Alvarez Martínez, Efraín ; González Martínez, Farith ; Rebolledo Cobos, Martha ; Aristizábal Gutiérrez, Fabio Ancízar ; Colegial, Carlos Humberto ; Horta, Alvaro ; Bustillo Rojas, Jairo Alberto ; Díaz Báez, David ; Ardila Medina, Carlos Martín ; Lafaurie Villamil, Gloria Inés. Human papilloma virus genotypes in dysplasia and epithelial hyperplasia of oral cavity using the luminex xmap technology. A multicenter study. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 1 2020: 1 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname Repositorio U. El Bosque Universidad El Bosque instacron:Universidad El Bosque Medicina Oral, Patología Oral y Cirugía Bucal RODERIC: Repositorio Institucional de la Universitat de Valéncia |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Epithelial dysplasia, Genotype, Population, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Epithelial hyperplasia, Internal medicine, Ensayo clínico, medicine, Humans, Papillomaviridae, education, General Dentistry, Oral Dysplasia, education.field_of_study, Oral Medicine and Pathology, Hyperplasia, biology, business.industry, Research, Papillomavirus Infections, Cancer, virus diseases, Electroforesis en gel bidimensional, 030206 dentistry, medicine.disease, biology.organism_classification, CIENCIAS MÉDICAS [UNESCO], female genital diseases and pregnancy complications, Enfermedades de la boca, Otorhinolaryngology, Dysplasia, UNESCO::CIENCIAS MÉDICAS, Surgery, HPV-genotypes, business |
| الوصف: | Background Oral cancer associated with high risk (HPV-HR) human papilloma virus (HPV) has been increasing. HPV-HR has been associated with epithelial dysplasia, however, little information exists on its frequency in epithelial hyperplasia lesions. The aim of this study is to compare HPV genotypes in dysplastic and hyperplastic lesions of oral cavity. Material and Methods Two hundred and fifty oral lesions: 131 dysplasia and 119 hyperplasia from two regions of Colombia were evaluated. One hundred seventy-four coming from urban area and 104 from a high risk population to oral cancer from a rural area. HPV was identified by qPCR and Twenty-four HPVs genotypes were evaluated by Luminex® technology. Logistic regressions were performed to establish the associations between HPV infections with oral dysplasia. Results Twenty-eight percent (70/250) of the samples were positives for any HPV and HPV-HRs were more frequently than low risk HPVs. HPV-16 was the most detected genotype (16%) followed by HPV-31, 53, 18 and 45. HPV, HPV-HRs and HPV-16 were only associated with dysplasia in urban area; OR 3.28 (CI 95% 1.49-7.17), OR 7.94 (CI 95% 2.97-21.2) and OR 5.90 (CI 95% 2.05-17). Individuals in rural area showed more HPV and HPV-HRs infection in hyperplasic lesions than urban population. The majority of HPV+ lesions had multi-type of HPV (52/70) and the urban individuals showed more genotypes than rural population. Conclusions HPV-.HRs are frequently found in hyperplastic and dysplastic epithelial lesions. HPV-HRs and HPV-16 were associated with dysplasia in urban population. Rural high risk population and urban population differ in the frequency and variety of HPV genotypes. Key words:Human papilloma virus, epithelial dysplasia, epithelial hyperplasia, HPV-genotypes. |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa075e5fbf2b82453c9d0bb23f20757Test https://hdl.handle.net/10550/77072Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....faa075e5fbf2b82453c9d0bb23f20757 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |