A retrospective analysis of the effects of different analgesics on the pain of patients with traumatic thoracolumbar fractures in the peri-treatment period
| العنوان: | A retrospective analysis of the effects of different analgesics on the pain of patients with traumatic thoracolumbar fractures in the peri-treatment period |
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| المؤلفون: | Ting-Ting Li, Song Wen, Ya-Ting Wang, Zong-Jin Gan, Liu-Lin Xiong, Quan-Yuan Chang, Hao Yuan, Jie Chen |
| المصدر: | Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-10 (2021) Journal of Orthopaedic Surgery and Research |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Time Factors, Diseases of the musculoskeletal system, Pain degree, Etoricoxib, 0302 clinical medicine, Risk Factors, Orthopedics and Sports Medicine, 030212 general & internal medicine, Spinal cord injury, Aged, 80 and over, Orthopedic surgery, Analgesics, Pain, Postoperative, Lumbar Vertebrae, Chronic pain, Middle Aged, Acute Pain, Dihydrocodeine, Drug Combinations, Acetaminophen dihydrocodeine, Anesthesia, Spinal Fractures, Female, Traumatic thoracolumbar fracture, Chronic Pain, Research Article, medicine.drug, Adult, musculoskeletal diseases, Adolescent, Visual analogue scale, Analgesic, Thoracic Vertebrae, Young Adult, 03 medical and health sciences, medicine, Humans, Spinal Cord Injuries, Acetaminophen, Aged, Retrospective Studies, Codeine, business.industry, Recovery of Function, medicine.disease, RC925-935, Celecoxib, Surgery, business, RD701-811, 030217 neurology & neurosurgery, Follow-Up Studies |
| الوصف: | Objective To analyze and compare the effects of peri-treatment analgesics on acute and chronic pain and postoperative functional recovery of patients with thoracolumbar fractures, so as to guide the clinical drug use. Methods Seven hundred nineteen patients with thoracolumbar fractures were collected and divided into acetaminophen dihydrocodeine, celecoxib, and etoricoxib groups. The main indicators were the degree of postoperative pain (visual analog scale (VAS)), the incidence of chronic pain and postoperative functional recovery (Oswestry dysfunction index (ODI) and Japanese Orthopedics Association score (JOA)), which were continuously tracked through long-term telephone follow-up. The correlation analysis of ODI-pain score, peri-treatment VAS score, and ODI index was performed, and bivariate regression analysis was conducted to understand the risk factors for chronic pain. Results Regression analysis showed that severe spinal cord injury and peri-treatment use of acetaminophen dihydrocodeine were both one of the risk factors for postoperative chronic pain. But there were no statistically conspicuous differences in basic characteristics, preoperative injury, and intraoperative conditions. Compared with the other two groups, patients in the acetaminophen dihydrocodeine group had longer peri-therapeutic analgesic use, higher pain-related scores (VAS 1 day preoperatively, VAS 1 month postoperatively, and ODI-pain 1 year postoperatively), higher VAS variation, higher incidence of chronic pain 1 year after surgery, and higher ODI index. And other ODI items and JOA assessments showed no statistically significant differences. In addition, the correlation analysis showed that the peri-treatment pain score was correlated with the severity of postoperative chronic pain. Conclusion Although the peri-treatment analgesic effect of acetaminophen dihydrocodeine is good, it is still necessary to combine analgesics with different mechanisms of action for patients with severe preoperative pain of thoracolumbar fracture, so as to inhibit the incidence of postoperative chronic pain and improve the quality of postoperative rehabilitation. |
| تدمد: | 1749-799X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92251243969964a5afdb739dccc43864Test https://doi.org/10.1186/s13018-021-02401-wTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....92251243969964a5afdb739dccc43864 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1749799X |
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