يعرض 1 - 10 نتائج من 15 نتيجة بحث عن '"Katsumi Higaki"', وقت الاستعلام: 1.58s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

    المؤلفون: Teresa Mena-Barragán, M. Isabel García-Moreno, Alen Sevšek, Tetsuya Okazaki, Eiji Nanba, Katsumi Higaki, Nathaniel I. Martin, Roland J. Pieters, José M. García Fernández, Carmen Ortiz Mellet

    المصدر: Molecules, Vol 23, Iss 4, p 927 (2018)

    مصطلحات موضوعية: sp2-Iminosugars, deoxynojirimycin, glycosidase inhibitors, glucocerebrosidase, chaperones, Gaucher disease, Organic chemistry, QD241-441

    وصف الملف: electronic resource

    العلاقة: http://www.mdpi.com/1420-3049/23/4/927Test; https://doaj.org/toc/1420-3049Test

    الوصول الحر: https://doaj.org/article/cc9793ab607a441ca19c10a8647494c4Test

    View record in DOAJ النص الكامل

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  2. 2
    Metabolic Alteration Analysis of Steroid Hormones in Niemann–Pick Disease Type C Model Cell Using Liquid Chromatography/Tandem Mass Spectrometry

    المؤلفون: Ai Abe, Masamitsu Maekawa, Toshihiro Sato, Yu Sato, Masaki Kumondai, Hayato Takahashi, Masafumi Kikuchi, Katsumi Higaki, Jiro Ogura, Nariyasu Mano

    المصدر: International Journal of Molecular Sciences; Volume 23; Issue 8; Pages: 4459

    مصطلحات موضوعية: Organic Chemistry, Reproducibility of Results, Niemann-Pick Disease, Type C, Niemann–Pick disease type C, steroid hormones, LC–MS/MS, mitochondria, ammonium solution, metabolic change, General Medicine, Hormones, Catalysis, Computer Science Applications, Inorganic Chemistry, stomatognathic diseases, Cholesterol, Tandem Mass Spectrometry, otorhinolaryngologic diseases, Humans, Steroids, Physical and Theoretical Chemistry, Molecular Biology, Biomarkers, Spectroscopy, Chromatography, Liquid

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265afa5252321a31f97dd966a0447573Test


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  3. 3
    Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann–Pick Disease Type C Model Mice

    المؤلفون: Yuki Kondo, Seiichi Shirakawa, Taishi Higashi, Naomi Nakagata, Muneaki Matsuo, Keiichi Motoyama, Hidetoshi Arima, Katsumi Higaki, Yusei Yamada, Toru Takeo, Tetsumi Irie, Takahiro Seki, Hiroshi Katsuki, Madoka Fukaura, Yoichi Ishitsuka, Yuki Kurauchi, Naoki Ushihama

    المصدر: International Journal of Molecular Sciences
    Volume 22
    Issue 1
    International Journal of Molecular Sciences, Vol 22, Iss 452, p 452 (2021)

    مصطلحات موضوعية: Male, medicine.disease_cause, lcsh:Chemistry, Mice, Purkinje Cells, Cerebellum, hemic and lymphatic diseases, lcsh:QH301-705.5, Melanoma, Spectroscopy, Neurons, Mutation, Membrane Glycoproteins, Niemann-Pick Disease, Type C, General Medicine, Pathophysiology, 2-Hydroxypropyl-beta-cyclodextrin, Computer Science Applications, Cholesterol, Infusions, Intraventricular, Liver, Biomarker (medicine), Female, medicine.medical_specialty, glycoprotein nonmetastatic melanoma B, 2-hydroxypropyl-β-cyclodextrin, Cerebellar Purkinje cell, Catalysis, Article, Inorganic Chemistry, Internal medicine, medicine, Animals, Physical and Theoretical Chemistry, Eye Proteins, Molecular Biology, Glycoproteins, Niemann–Pick disease, type C, GPNMB, business.industry, Organic Chemistry, Therapeutic effect, nutritional and metabolic diseases, Niemann–Pick disease type C, medicine.disease, Disease Models, Animal, Endocrinology, lcsh:Biology (General), lcsh:QD1-999, NPC1, business, Biomarkers

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fc44fe85a344e161c714222eed7b15Test
    http://europepmc.org/articles/PMC7795151Test


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  4. 4
    Morquio B Disease. Disease Characteristics and Treatment Options of a Distinct GLB1-Related Dysostosis Multiplex

    المؤلفون: Katsumi Higaki, Sylvia Stockler-Ipsiroglu, Nataliya Yuskiv

    المصدر: International Journal of Molecular Sciences, Vol 21, Iss 9121, p 9121 (2020)

    مصطلحات موضوعية: 0301 basic medicine, GM1 gangliosidosis, Ataxia, 030105 genetics & heredity, Bioinformatics, Catalysis, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, medicine, Lysosomal storage disease, Physical and Theoretical Chemistry, lcsh:QH301-705.5, Molecular Biology, Kyphoscoliosis, Spectroscopy, Dystonia, keratan sulfate, business.industry, MPS4B, Odontoid Hypoplasia, Organic Chemistry, Dysostosis, General Medicine, medicine.disease, beta-galactosidase, Computer Science Applications, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, GLB1, Speech delay, medicine.symptom, business, Mucopolysaccharidosis type 4

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a972bf4dc45f08eddb9a53e8ca02f98aTest


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  5. 5
    Role of 6-O-α-maltosyl-β-cyclodextrin in lysosomal cholesterol deprivation in Npc1-deficient Chinese hamster ovary cells

    المؤلفون: Katsumi Higaki, Jun-ichi Nishikawa, Yasuyo Okada, Kousaku Ohno, Yoichi Ishitsuka, Erika Ueda, Keiichi Motoyama, Hidetoshi Arima, Yuki Kondo, Tetsumi Irie, Atsushi Ichikawa, Muneaki Matuso, Taishi Higashi

    المصدر: Carbohydrate Research. 455:54-61

    مصطلحات موضوعية: 0301 basic medicine, Cell type, media_common.quotation_subject, Cell, CHO Cells, Endocytosis, Biochemistry, Mass Spectrometry, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Cricetulus, 0302 clinical medicine, Cricetinae, medicine, Extracellular, Animals, Internalization, media_common, Chemistry, Cholesterol, Chinese hamster ovary cell, beta-Cyclodextrins, Organic Chemistry, General Medicine, Molecular biology, Cell biology, carbohydrates (lipids), 030104 developmental biology, medicine.anatomical_structure, lipids (amino acids, peptides, and proteins), NPC1, Lysosomes, 030217 neurology & neurosurgery, Chromatography, Liquid

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f3d41e4851846c3dc316f46f5d62ddTest
    https://doi.org/10.1016/j.carres.2017.11.003Test


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  6. 6
    (5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B

    المؤلفون: Katsumi Higaki, Estelle Gallienne, Anna Biela-Banaś, Sophie Front, Olivier R. Martin, Amelia Morrone, Diana Ballhausen, Anna Caciotti, Julie Charollais-Thoenig, Stéphane Demotz, Patricie Burda

    المساهمون: University of Zurich, Martin, Olivier R

    المصدر: European Journal of Medicinal Chemistry. 126:160-170

    مصطلحات موضوعية: 0301 basic medicine, Protein Denaturation, Hot Temperature, Mutant, 610 Medicine & health, 03 medical and health sciences, Drug Discovery, Humans, Glycoside hydrolase, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Gangliosidosis, GM1, biology, Drug discovery, 3002 Drug Discovery, Organic Chemistry, Mucopolysaccharidosis IV, General Medicine, Fibroblasts, Hydrogen-Ion Concentration, beta-Galactosidase, 3004 Pharmacology, 030104 developmental biology, Enzyme, chemistry, Biochemistry, 10036 Medical Clinic, Cell culture, Drug Design, Chaperone (protein), Mutation, biology.protein, Epimer, Lysosomes, Selectivity, Imino Pyranoses, 1605 Organic Chemistry

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9533b0f69d6f920eceaafce0d89380bTest
    https://doi.org/10.1016/j.ejmech.2016.09.095Test


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  7. 7
    In Vitro and In Vivo Evaluation of 6-O-α-Maltosyl-β-Cyclodextrin as a Potential Therapeutic Agent Against Niemann-Pick Disease Type C

    المؤلفون: Yasuyo Okada, Muneaki Matsuo, Jun-ichi Nishikawa, Daisuke Iohara, Naomi Nakagata, Taishi Higashi, Fumitoshi Hirayama, Toru Takeo, Keiichi Motoyama, Madoka Fukaura, Yoichi Ishitsuka, Tetsumi Irie, Katsumi Higaki, Yusei Yamada, Nushrat Yasmin, Yuki Kondo, Akira Ishii, Shuichi Nakahara, Kousaku Ohno, Atsushi Ichikawa

    المصدر: International Journal of Molecular Sciences, Vol 20, Iss 5, p 1152 (2019)
    International Journal of Molecular Sciences
    Volume 20
    Issue 5

    مصطلحات موضوعية: 0301 basic medicine, 6-O-α-maltosyl-β-cyclodextrin, Pharmacology, lcsh:Chemistry, chemistry.chemical_compound, Mice, 0302 clinical medicine, Cricetinae, Lysosomal storage disease, lcsh:QH301-705.5, Spectroscopy, Chemistry, Chinese hamster ovary cell, beta-Cyclodextrins, Niemann-Pick disease type C, Niemann-Pick Disease, Type C, General Medicine, Computer Science Applications, medicine.anatomical_structure, Cholesterol, Treatment Outcome, Injections, Subcutaneous, 2-hydroxypropyl-β-cyclodextrin, CHO Cells, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Cricetulus, In vivo, Niemann-Pick C1 Protein, Lysosome, medicine, Animals, Physical and Theoretical Chemistry, Molecular Biology, Nuclear Magnetic Resonance, Biomolecular, Niemann–Pick disease, type C, Dose-Response Relationship, Drug, Organic Chemistry, medicine.disease, In vitro, Disease Models, Animal, 030104 developmental biology, cyclodextrin, lcsh:Biology (General), lcsh:QD1-999, NPC1, 030217 neurology & neurosurgery

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff9de168c418eb4ffb5e996f2169f68Test
    http://www.mdpi.com/1422-0067/20/5/1152Test


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  8. 8
    Potent chemical chaperone compounds for GM1-gangliosidosis: N-substituted (+)-conduramine F-4 derivatives

    المؤلفون: Eiji Nanba, Shinichi Kuno, Atsushi Takahashi, Seiichiro Ogawa, Katsumi Higaki

    المصدر: MedChemComm. 6:306-310

    مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, biology, Stereochemistry, GM1 Gangliosidosis, Organic Chemistry, Pharmaceutical Science, Biochemistry, Enzyme, chemistry, Chaperone (protein), Drug Discovery, biology.protein, Molecular Medicine, Chemical chaperone

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::10bd0e8a002ab519f7fcf4949af0cb82Test
    https://doi.org/10.1039/c4md00270aTest


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  9. 9
    Efficient stereoselective synthesis of 2-acetamido-1,2- dideoxyallonojirimycin (DAJNAc) and sp2-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme

    المؤلفون: Xavier Verdaguer, José M. García Fernández, Katsumi Higaki, Eiji Nanba, Alex de la Fuente, Antoni Riera, Carmen Ortiz Mellet, Rocío Rísquez-Cuadro

    المساهمون: Universidad de Sevilla. Departamento de Química orgánica, Ministerio de Economía y Competitividad (MINECO). España, Junta de Andalucía, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), European Commission. Fondo Social Europeo (FSO), Universidad de Sevilla

    المصدر: Digital.CSIC. Repositorio Institucional del CSIC
    instname
    idUS. Depósito de Investigación de la Universidad de Sevilla

    مصطلحات موضوعية: Models, Molecular, 1-Deoxynojirimycin, Stereochemistry, Hexosaminidase inhibitors, Mutant, Molecular Conformation, Iminosugar, Chemistry Techniques, Synthetic, Tay-Sachs disease, 010402 general chemistry, 01 natural sciences, Drug Discovery, Humans, Hexosaminidase, Glycoside hydrolase, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Bicyclic molecule, 010405 organic chemistry, Organic Chemistry, Stereoselective synthesis, Stereoisomerism, General Medicine, Pharmacological chaperones, Imino Sugars, 0104 chemical sciences, Hexosaminidases, Kinetics, Enzyme, chemistry, Biochemistry, sp2-iminosugars, Stereoselectivity

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5cdb2c357f4536852ffe09288c201aTest
    http://hdl.handle.net/10261/137497Test


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  10. 10
    Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts

    المؤلفون: C. Ortiz Mellet, Elena M. Sánchez-Fernández, Alberto Avenoza, Jesús H. Busto, Claudio D. Navo, Francisco Corzana, Jesús M. Peregrina, María M. Zurbano, J. M. Garcia Fernandez, Katsumi Higaki, Eiji Nanba

    المصدر: idUS. Depósito de Investigación de la Universidad de Sevilla
    instname
    Digital.CSIC. Repositorio Institucional del CSIC

    مصطلحات موضوعية: Models, Molecular, Stereochemistry, Substituent, Molecular Conformation, Molecular Dynamics Simulation, 010402 general chemistry, 01 natural sciences, Biochemistry, Adduct, chemistry.chemical_compound, Structure-Activity Relationship, medicine, Structure–activity relationship, Animals, Humans, Glycosides, Physical and Theoretical Chemistry, Enzyme Inhibitors, Gaucher Disease, biology, Dose-Response Relationship, Drug, 010405 organic chemistry, beta-Glucosidase, Organic Chemistry, Monosaccharides, Fibroblasts, beta-Galactosidase, In vitro, 0104 chemical sciences, Pharmacological chaperone, Aglycone, chemistry, Liver, Chaperone (protein), biology.protein, Glucosylceramidase, Stereoselectivity, Cattle, medicine.drug, Molecular Chaperones

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c307827e07b3343f3a6f5db7ccd20bcfTest
    http://hdl.handle.net/10261/128806Test


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