دورية أكاديمية
Oral Cytokine Levels Are More Linked to Levels of Plasma and Oral HIV-1 RNA Than to CD4+ T-Cell Counts in People With HIV
| العنوان: | Oral Cytokine Levels Are More Linked to Levels of Plasma and Oral HIV-1 RNA Than to CD4+ T-Cell Counts in People With HIV |
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| المؤلفون: | Rocco, Joseph M, York, Zachary, Shen, Chengli, Shiboski, Caroline, Cyriaque-Webster, Jennifer, McLaughlin, Janet, Borowski, Luann, Chen, Huichao, Aberg, Judith A, Dittmer, Dirk P, Ghannoum, Mahmoud, Rinaldo, Charles R, Macatangay, Bernard |
| المساهمون: | National Institutes of Health, National Institutes of Health Cooperative Agreement, National Institute of Allergy and Infectious Diseases, National Institute of Dental and Craniofacial Research, Department of Medicine of the University of Pittsburgh School of Medicine |
| المصدر: | Open Forum Infectious Diseases ; volume 7, issue 3 ; ISSN 2328-8957 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Infectious Diseases, Oncology |
| الوصف: | Background We determined the levels of 11 soluble immune mediators in oral washings of AIDS Clinical Trials Group A5254 participants with varying degrees of plasma viremia and CD4 T-cell counts to characterize the mucosal immune response at different stages of HIV-1 infection. Methods A5254 was a multicenter, cross-sectional study in people with HIV (PWH) recruited into 4 strata based on CD4 count and levels of plasma viremia: stratum (St) A: CD4 ≤200 cells/mm3, HIV-1 RNA (viral load [VL]) >1000 cps/mL; St B: CD4 ≤200, VL ≤1000; St C: CD4 >200, VL >1000; St D: CD4 >200, VL ≤1000. Oral/throat washings were obtained from all participants. Soluble markers were tested in oral/throat washings using a multibead fluorescent platform and were compared across strata. Linear regression was used to determine the associations between cytokines and HIV-1 in plasma and oral fluid. Results St A participants had higher levels of interleukin (IL)-1β, IL-6, IL-17, tumor necrosis factor alpha (TNFα), and interferon gamma (IFNγ) compared with St B and D (P = .02; P < .0001) but were not different from St C. IL-8, IL-10, and IL-12 were elevated in St A compared with the other 3 strata (P = .046; P < .0001). Linear regression demonstrated that oral HIV-1 levels were associated with IL-1β, IL-6, IL-8, and TNFα production (R > .40; P < .001) when controlling for CD4 count and opportunistic infections. Conclusions Our results show that high levels of oral HIV-1, rather than low CD4 counts, were linked to the production of oral immune mediators. Participants with AIDS and uncontrolled viremia demonstrated higher levels of pro- and anti-inflammatory soluble immune mediators compared with participants with lower HIV-1 RNA. The interplay of HIV-1 and these immune mediators could be important in the oral health of PWH. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ofid/ofaa047 |
| DOI: | 10.1093/ofid/ofaa047/32449103/ofaa047.pdf |
| الإتاحة: | https://doi.org/10.1093/ofid/ofaa047Test http://academic.oup.com/ofid/article-pdf/7/3/ofaa047/32744106/ofaa047.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.7B1C90FA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ofid/ofaa047 |
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