يعرض 1 - 10 نتائج من 30 نتيجة بحث عن '"Tim Harrison"', وقت الاستعلام: 0.78s تنقيح النتائج
  1. 1
    Abstract LB011: Development of novel protein drug conjugates (PDCs) for the selective targeting of ALPP/ALPPL2 expressing tumors

    المؤلفون: Graham Cotton, Paul Trumper, Estelle McLean, Mark Wappett, Stacey Bell, Greg Papadakos, Jennifer Thom, Chiara Saladino, Aaron Cranston, Georgiana Parau, Stephanie Gatdula, Stephanie Burton, Aidan McCann, Tim Harrison

    المصدر: Cancer Research. 83:LB011-LB011

    مصطلحات موضوعية: Cancer Research, Oncology

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7d7e398a812ab096a0512732af277540Test
    https://doi.org/10.1158/1538-7445.am2023-lb011Test


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  2. 2
    Abstract LB096: Development of a next generation ROR1 targeting Protein Drug Conjugate (PDC)

    المؤلفون: Chiara Saladino, Andrew C.G. Porter, Estelle McLean, Mark Wappett, Aaron Cranston, Tim Harrison, Stacey Bell, Jennifer Thom, Marina Kovaleva, Aidan P. McCann, Trumper Paul Richard, Graham Cotton, Caroline J. Barelle

    المصدر: Cancer Research. 81:LB096-LB096

    مصطلحات موضوعية: Cancer Research, Drug discovery, business.industry, medicine.medical_treatment, Cancer, medicine.disease_cause, medicine.disease, Targeted therapy, Oncology, ROR1, medicine, Cancer research, Adenocarcinoma, Carcinogenesis, Ovarian cancer, business, Triple-negative breast cancer

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0ce5bf11318a700e628c7657f977339eTest
    https://doi.org/10.1158/1538-7445.am2021-lb096Test


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  3. 3
    Abstract 1342: Development and preclinical evaluation of unique first-in-class small molecule inhibitors of the anti-apoptotic protein FLIP

    المؤلفون: Jennifer Fox, Catherine A. Higgins, Trevor Perrior, Declan Doherty, Daniel B. Longley, Jamie Z. Roberts, Tim Harrison, Raymond John Boffey

    المصدر: Cancer Research. 81:1342-1342

    مصطلحات موضوعية: Cancer Research, Programmed cell death, business.industry, Necroptosis, Pyroptosis, Cancer, medicine.disease, medicine.disease_cause, Oncology, Flip, Cancer research, Medicine, Osimertinib, KRAS, business, EGFR inhibitors

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5ef167029f19d573e9c35e4fbf8772fcTest
    https://doi.org/10.1158/1538-7445.am2021-1342Test


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  4. 4
    Abstract 5220: Development of first-in-class small molecule inhibitors of FLIP which activate caspase-8, the nodal regulator of apoptosis, necroptosis and pyroptosis

    المؤلفون: Daniel B. Longley, Jamie Z. Roberts, Jennifer Fox, Raymond John Boffey, Martin J. Page, Tim Harrison, Sophie Williams, Trevor Perrior, Catherine A. Higgins

    المصدر: Cancer Research. 80:5220-5220

    مصطلحات موضوعية: Cancer Research, Oncology, Chemistry, Flip, Apoptosis, Necroptosis, Regulator, Pyroptosis, NODAL, Caspase 8, Small molecule, Cell biology

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::8adab3ce0220b62216440c3d6de81c46Test
    https://doi.org/10.1158/1538-7445.am2020-5220Test


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  5. 5
    Abstract 538: Exploiting the properties of VNAR domains for the development of novel efficacious protein drug conjugates targeting the oncofetal protein ROR1

    المؤلفون: Marina Kovaleva, Aaron Cranston, Andrew C.G. Porter, Mark Wappett, Estelle McLean, Chiara Saladino, Graham Cotton, Stacey Bell, Andrei Kamenski, Alicia Campion, Trumper Paul Richard, Jennifer Thom, Elisa Persiani, Aidan P. McCann, Caroline J. Barelle, Tim Harrison

    المصدر: Cancer Research. 80:538-538

    مصطلحات موضوعية: 0301 basic medicine, Cancer Research, biology, Drug discovery, Cancer, medicine.disease, medicine.disease_cause, Receptor tyrosine kinase, In vitro, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, In vivo, 030220 oncology & carcinogenesis, ROR1, medicine, Cancer research, biology.protein, Carcinogenesis, Triple-negative breast cancer

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7c5075206517a9efbcb5c4e86f43aff4Test
    https://doi.org/10.1158/1538-7445.am2020-538Test


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  6. 6
    Delivering a research-enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program

    المؤلفون: Margaret Grayson, Anna Gavin, Tracy Robson, Jacqueline James, Manuel Salto-Tellez, Kevin M. Prise, Robert D. Ladner, Liam J. Murray, David Waugh, Peter W. Hamilton, Patrick G. Johnston, Richard D. Kennedy, Darragh G. McArt, Ruth Boyd, Richard H. Wilson, Sandra Van Schaeybroeck, Tim Harrison, Mark Lawler, Joe M. O'Sullivan, Denis Paul Harkin

    المصدر: Cancer. 122:664-673

    مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Government, Population level, business.industry, Northern ireland, Precision medicine, Ethos, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Transformative learning, Oncology, Nursing, 030220 oncology & carcinogenesis, General partnership, Health care, Medicine, business, health care economics and organizations

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e8cbdb1eca3ecde13ee78552648a67fdTest
    https://doi.org/10.1002/cncr.29814Test


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  7. 7
    FLIP: A Targetable Mediator of Resistance to Radiation in Non-Small Cell Lung Cancer

    المؤلفون: Zsuzsanna Németh, Izabela Stasik, Catherine Fenning, Kevin M. Prise, Conor A Bradley, Kylie A. McLaughlin, Gerard G Hanna, Joanna Majkut, Catherine A. Higgins, Caitriona Holohan, Nyree Crawford, Luke M Humphreys, Patrick G. Johnston, Karl T. Butterworth, Tim Harrison, Daniel B. Longley

    المصدر: McLaughlin, K A, Nemeth, Z, Bradley, C A, Humphreys, L, Stasik, I, Fenning, C, Majkut, J, Higgins, C, Crawford, N, Holohan, C, Johnston, P G, Harrison, T, Hanna, G G, Butterworth, K T, Prise, K M & Longley, D B 2016, ' FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer ', Molecular Cancer Therapeutics, pp. 2432-2441 . https://doi.org/10.1158/1535-7163.MCT-16-0211Test

    مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Programmed cell death, Lung Neoplasms, CASP8 and FADD-Like Apoptosis Regulating Protein, Antineoplastic Agents, Apoptosis, Radiation Tolerance, 03 medical and health sciences, chemistry.chemical_compound, SDG 3 - Good Health and Well-being, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, medicine, Humans, FADD, RNA, Small Interfering, Vorinostat, biology, Entinostat, B131, A100, 3. Good health, Cell biology, Gene Expression Regulation, Neoplastic, Histone Deacetylase Inhibitors, 030104 developmental biology, Oncology, chemistry, Flip, Cancer cell, biology.protein, RNA Interference, Signal transduction, Signal Transduction, medicine.drug

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9624689e51f6f3159a704334f4c46266Test
    https://clok.uclan.ac.uk/18161/1/18161_stasik.pdfTest


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  8. 8
    Abstract 704: RALB GTPase: A critical regulator of DR5 cell surface expression and TRAIL sensitivity in RAS mutant colorectal cancer

    المؤلفون: Hajrah Khawaja, Jamie Z. Roberts, Arman Javadi, Paul O'Reilly, Darragh McArt, Wendy L. Allen, Markus Morrison, Richard Kennedy, Nicolas Vitale, Patrick G. Johnston, Tim Harrison, Daniel B. Longley, Emma Evergren, Sandra Van Schaeybroeck

    المصدر: Cancer Research. 79:704-704

    مصطلحات موضوعية: Cancer Research, Oncology

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7ac589013a392cfa463aa6be83141c77Test
    https://doi.org/10.1158/1538-7445.am2019-704Test


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  9. 9
    Abstract 222: Novel protein drug conjugates targeting ROR1 through the development and exploitation of a drug discovery platform based on small, engineered VNAR domains

    المؤلفون: Trumper Paul Richard, Stacey Bell, Aaron Cranston, Caroline J. Barelle, Andrew C.G. Porter, Andrei Kamenski, Chiara Saladino, Estelle McLean, Marina Kovaleva, Jennifer Thom, Aidan P. McCann, John Steven, Mark Wappett, Graham Cotton, Tim Harrison

    المصدر: Cancer Research. 79:222-222

    مصطلحات موضوعية: 0301 basic medicine, Cancer Research, biology, Drug discovery, Protein domain, ROR2, Protein engineering, Computational biology, Receptor tyrosine kinase, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, ROR1, biology.protein, Cytotoxic T cell, Antibody

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::83e6aa33418b4a49d7e79448b51f84c1Test
    https://doi.org/10.1158/1538-7445.am2019-222Test


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  10. 10
    Abstract LB-049: Targeting the ubiquitin-proteasome system by small molecule inhibition of the DUBome

    المؤلفون: Ewelina Rozycka, Stephanie Burton, Natalie Page, Christina Bell, Steven Whitehead, Matthew Helm, Colin O'Dowd, Oliver Barker, Frank Burkamp, Steven Shepherd, Gerald Gavory, Eamon Cassidy, Shane Rountree, Tim Harrison, Peter Hewitt, Xavier Jacq, Mark Wappett

    المصدر: Cancer Research. 79:LB-049

    مصطلحات موضوعية: Cancer Research, Proteases, Oncology, Ubiquitin, Proteasome, Drug discovery, biology.protein, Computational biology, Biology, Protein degradation, Small molecule, Protein ubiquitination, Deubiquitinating enzyme

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b335541ffa3408590a07af3c2fc2b81eTest
    https://doi.org/10.1158/1538-7445.am2019-lb-049Test


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