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1دورية أكاديمية
المؤلفون: Yin, Xiaoran, Feng, Yan, Zhang, Bowen, Mao, Xueyan, Chen, Siying, Wang, Yuyan, Fu, Sidney W.
المصدر: Frontiers in Oncology ; volume 13 ; ISSN 2234-943X
مصطلحات موضوعية: Cancer Research, Oncology
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2دورية أكاديمية
المؤلفون: Ren, Shuchang, Tan, Xiaohui, Fu, Melinda Z., Ren, Shuyang, Wu, Xiaoling, Chen, Tao, Latham, Patricia S., Lin, Paul, Man, Yan-gao, Fu, Sidney W.
المصدر: Journal of Cancer ; volume 12, issue 23, page 7138-7146 ; ISSN 1837-9664
مصطلحات موضوعية: Oncology
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3دورية أكاديمية
المؤلفون: Liu, Xinghan, Wang, Xijing, Fu, Sidney W., Dai, Zhijun, + 9 more
المصدر: Medicine Faculty Publications
مصطلحات موضوعية: Medicine and Health Sciences, Oncology
الوصف: Deleted in colorectal carcinoma (DCC), a netrin-1 dependence receptor, is correlated with cell progression, migration, and adhesion. Evidence indicated that DCC was frequently down-regulated in many cancers. However, the association of DCC with breast cancer remains uncertain. We conducted a case-control study to investigate the impact of three DCC gene variants (rs2229080, rs7504990, and rs4078288) on breast cancer susceptibility in Chinese women. This study included 560 breast cancer patients and 583 age-matched healthy controls from Northwest China. The three gene variants were genotyped via Sequenom MassARRAY. Odds ratios (ORs) and 95% confidence intervals (CIs) were utilized to evaluate the associations. We found that individuals with the rs2229080 C/G, C/C, and C/G-CC genotypes had a higher breast cancer risk, and the minor allele C was associated with increased breast cancer risk in an allele model. We observed a significantly decreased breast cancer risk with the rs7504990 C/T, T/T, and C/T-T/T genotypes, and the minor allele T was protective against breast cancer in an allele model. In addition, rs2229080 was associated with the axillary lymph node (LN) metastasis status. An age-stratified analysis revealed an association between rs2229080 and reduced breast cancer risk among older patients (≥ 49 years). Furthermore, the haplotype analysis showed that the Crs2229080Crs7504990Ars4078288 haplotype was associated with a decreased breast cancer risk. However, the results indicated a lack of association between rs4078288 and breast cancer risk. These findings affirmed that rs2229080 and rs7504990 polymorphisms inDCC might be related with breast cancer susceptibility in Chinese women.
وصف الملف: application/pdf
العلاقة: https://hsrc.himmelfarb.gwu.edu/smhs_medicine_facpubs/736Test; https://hsrc.himmelfarb.gwu.edu/cgi/viewcontent.cgi?article=1736&context=smhs_medicine_facpubsTest
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4دورية أكاديمية
المؤلفون: Wang, Meng, Wang, Xijing, Fu, Sidney W., Dai, Zhijun, Jin, Tianbo, + 10 additional authors
المصدر: Medicine Faculty Publications
مصطلحات موضوعية: Medicine and Health Sciences, Neoplasms, Oncology
الوصف: This study explored the associations between common PSCA single-nucleotide polymorphisms (rs2294008, rs2978974, and rs2976392) and breast cancer among 560 breast cancer cases and 583 controls (Chinese Han women). We found rs2294008 was significantly associated with a high risk of breast cancer (homozygote model, odds ratio [OR]: 1.67, 95% confidence interval [CI]: 1.06–2.59; recessive, OR: 1.64, 95% CI: 1.06–2.53). And stratification by menopausal status revealed an association of the minor allele of rs2294008 with breast cancer risk among premenopausal (homozygote model, OR: 2.41, 95% CI: 1.03–5.66; recessive, OR: 2.80, 95 % CI: 1.21–6.47) and postmenopausal women (allele model, OR: 1.29, 95% CI: 1.01–1.65). Rs2978974 influenced the breast cancer risk among postmenopausal women in heterozygote model (OR: 1.47, 95% CI: 1.05–2.07). When stratified by clinicopathologic features, the T allele of rs2294008 was associated with progesterone receptor status (homozygote model, OR: 1.98, 95% CI: 1.08–3.63; recessive, OR: 1.87, 95% CI: 1.04–3.37), and the rs2976392 polymorphism was associated with high lymph node metastasis risk in homozygote model (OR: 2.09, 95%CI: 1.01–4.31). Further haplotype analysis suggested that Trs2294008 Ars2976392 Grs2978974haplotype enhances breast cancer risk (OR:1.52, 95%CI:1.23-1.89, P<0.001). Therefore, among Chinese Han women, the PSCArs2294008, rs2978974, and rs2976392 minor alleles are associated with increased breast cancer risk especially in progesterone receptor positive breast cancer patients, with breast cancer risk in postmenopausal women, and with high lymph node metastasis risk, respectively. Moreover, Trs2294008 Ars2976392 Grs2978974 haplotype was associated with significantly increased risk of breast cancer.
وصف الملف: application/pdf
العلاقة: https://hsrc.himmelfarb.gwu.edu/smhs_medicine_facpubs/730Test; https://hsrc.himmelfarb.gwu.edu/cgi/viewcontent.cgi?article=1730&context=smhs_medicine_facpubsTest
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5دورية أكاديمية
المؤلفون: Fu, Sidney W., Lee, Woojin, Coffey, Caitrin M., Lea, Alexa, Wu, Xiaoling, Tan, Xiaohui, Man, Yan-Gao, Brem, Rachel F.
المصدر: Medicine Faculty Publications
مصطلحات موضوعية: Genetics and Genomics, Medicine and Health Sciences, Oncology
الوصف: Breast cancer is the most common cancer among American women, except for skin cancers. About 12 % women in the United States will develop invasive breast cancer during their lifetime. Currently one of the most accepted model/theories is that ductal breast cancer (most common type of breast cancer) follows a linear progression: from normal breast epithelial cells to ductal hyperplasia to atypical ductal hyperplasia (ADH) to ductal carcinoma in situ (DCIS), and finally to invasive ductal carcinoma (IDC). Distinguishing pure ADH diagnosis from DCIS and/or IDC on mammography, and even combined with follow-up core needle biopsy (CNB) is still a challenge. Therefore subsequent surgical excision cannot be avoided to make a definitive diagnosis. MicroRNAs (miRNAs) are a highly abundant class of endogenous non-coding RNAs, which contribute to cancer initiation and progression, and are differentially expressed between normal and cancer tissues. They can function as either tumor suppressors or oncogenes. With accumulating evidence of the role of miRNAs in breast cancer progression, including our own studies, we sought to summarize the nature of early breast lesions and the potential use of miRNA molecules as biomarkers in early breast cancer detection. In particular, miRNA biomarkers may potentially serve as a companion tool following mammography screening and CNB. In the long-term, a better understanding of the molecular mechanisms underlying the miRNA signatures associated with breast cancer development could potentially result in the development of novel strategies for disease prevention and therapy.
وصف الملف: application/pdf
العلاقة: https://hsrc.himmelfarb.gwu.edu/smhs_medicine_facpubs/689Test; https://hsrc.himmelfarb.gwu.edu/cgi/viewcontent.cgi?article=1689&context=smhs_medicine_facpubsTest
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6دورية أكاديمية
المؤلفون: Lean, Alexa, Yang, Jialu Lucy, Tan, Xiaohui, Teal, Christine B., Brem, Rachel F., Fu, Sidney W.
المصدر: GW Research Days 2016 - 2020
مصطلحات موضوعية: Oncology
الوصف: The currently accepted stepwise model of breast tumorigenesis assumes a gradual transition from normal breast epithelial cells to atypical ductal hyperplasia (ADH), to ductal carcinoma in situ (DCIS) and then to invasive ductal carcinoma (IDC). Percutaneous core needle biopsy (CNB) is the standard technique following an abnormal mammographic finding. However, CNB is less reliable in differentiating simple ADH (sADH) from ADH component coexisted with advanced lesions such as DCIS and/or IDC (cADH). Therefore, to identify and validate novel reliable molecular biomarkers is essential in order to improve the efficiency of therapeutic recommendations, as well as to minimize anxiety and unnecessary procedures. miRNAs function as tumor suppressors or oncogenes and play a critical role in cancer initiation and progression by regulating their target genes. Unlike messenger RNAs (mRNAs), which could be easily degraded, miRNAs are found to be stable not only in body fluid, but also in Formalin-Fixed, Paraffin-Embedded (FFPE) tissues. The stability of miRNAs in FFPE and blood samples suggests that they may be the ideal biomarkers for the early diagnosis and prognosis of cancer, including breast cancer. The goal of this research is to use FFPE and blood samples from the two different groups of patients, analyze the candidate miRNAs to differentiating simple sADH from cADH. In our published studies, we identified a series of miRNAs that are differentially expressed during stepwise transition of breast carcinogenesis, including miR-671-5p. In this study, we showed that the expression of miR-671-5p and miR-638 decreases in ADH, DCIS, and IDC compared with the matched adjacent normal tissues. In addition, we examined the candidate miRNA expression in two groups of ADH blood samples: 28 sADHs and 32 cADHs by qRT-PCR. We found that miR-671-5p expression was decreased in cADHs, but not in sADHs, compared with their matched normal controls. Our recent publication demonstrated that miR-671-5p functions as a tumor suppressor miRNA ...
وصف الملف: application/pdf
العلاقة: https://hsrc.himmelfarb.gwu.edu/gw_research_days/2016/SMHS/62Test; https://hsrc.himmelfarb.gwu.edu/context/gw_research_days/article/1068/viewcontent/Circulating_miRNA_Biomarkers_in_Early_Breast_Cancer_Detection_following_Mammography_ALean.pdfTest
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7دورية أكاديمية
المؤلفون: Tan, Xiaohui, Wu, Xiaoling, Ren, Shuyang, Wang, Hongyi, Li, Zhongwu, Alshenawy, Weaam, Li, Wenmei, Cui, Jiantao, Luo, Guangbin, Siegel, Robert S., Fu, Sidney W., Lu, Youyong
المصدر: Journal of Cancer ; volume 7, issue 11, page 1472-1480 ; ISSN 1837-9664
مصطلحات موضوعية: Oncology
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8دورية أكاديمية
المؤلفون: Tan, Xiaohui, Wang, Hongyi, Luo, Guangbin, Ren, Shuyang, Li, Wenmei, Cui, Jiantao, Gill, Harindarpal S., Fu, Sidney W., Lu, Youyong
المصدر: Medicine Faculty Publications
مصطلحات موضوعية: Biomarkers, Tumor--genetics, DNA Polymerase beta--genetics, Point Mutation--genetics, Stomach Neoplasms--genetics, Adult, Aged, 80 and over, Tumor, Blotting, Western, Cell Line, DNA Polymerase beta, Female, Humans, Male, Middle Aged, Point Mutation, Polymerase Chain Reaction, Stomach Neoplasms, Cancer Biology, Medicine and Health Sciences, Neoplasms, Oncology
الوصف: Gastric cancer (GC) is a major cause of global cancer mortality. Genetic variations in DNA repair genes can modulate DNA repair capability and, consequently, have been associated with risk of developing cancer. We have previously identified a T to C point mutation at nucleotide 889 (T889C) in DNA polymerase beta (POLB) gene, a key enzyme involved in base excision repair in primary GCs. The purpose of this study was to evaluate the mutation and expression of POLB in a larger cohort and to identify possible prognostic roles of the POLB alterations in GC. Primary GC specimens and their matched normal adjacent tissues were collected at the time of surgery. DNA, RNA and protein samples were isolated from GC specimens and cell lines. Mutations were detected by PCR-RFLP/DHPLC and sequencing analysis. POLB gene expression was examined by RT-PCR, tissue microarray, Western blotting and immunofluorescence assays. The function of the mutation was evaluated by chemosensitivity, MTT, Transwell matrigel invasion and host cell reactivation assays. The T889C mutation was detected in 18 (10.17%) of 177 GC patients. And the T889C mutation was associated with POLB overexpression, lymph nodes metastases and poor tumor differentiation. In addition, patients with- the mutation had significantly shorter survival time than those without-, following postoperative chemotherapy. Furthermore, cell lines with T889C mutation in POLB gene were more resistant to the treatment of 5-fluorouracil, cisplatin and epirubicin than those with wild type POLB. Forced expression of POLB gene with T889C mutation resulted in enhanced cell proliferation, invasion and resistance to anticancer drugs, along with increased DNA repair capability. These results suggest that POLB gene with T889C mutation in surgically resected primary gastric tissues may be clinically useful for predicting responsiveness to chemotherapy in patients with GC. The POLB gene alteration may serve as a prognostic biomarker for GC.
وصف الملف: application/pdf
العلاقة: https://hsrc.himmelfarb.gwu.edu/smhs_medicine_facpubs/834Test; https://hsrc.himmelfarb.gwu.edu/cgi/viewcontent.cgi?article=1834&context=smhs_medicine_facpubsTest
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9دورية أكاديمية
المؤلفون: Wu, Xiaoling, Tan, Xiaohui, Fu, Sidney W.
المصدر: Journal of Cancer ; volume 6, issue 12, page 1206-1213 ; ISSN 1837-9664
مصطلحات موضوعية: Oncology
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10دورية أكاديمية
المؤلفون: Shen, Fengmei, Mo, Meng-Hsuan, Chen, Liang, An, Shejuan, Tan, Xiaohui, Fu, Yebo, Rezaei, Katayoon, Wang, Zuoren, Zhang, Lin, Fu, Sidney W.
المصدر: Journal of Cancer ; volume 5, issue 9, page 804-812 ; ISSN 1837-9664
مصطلحات موضوعية: Oncology
