دورية أكاديمية
Intraductal papillary neoplasms of the bile duct: A European retrospective multicenter observational study (EUR-IPNB Study).
| العنوان: | Intraductal papillary neoplasms of the bile duct: A European retrospective multicenter observational study (EUR-IPNB Study). |
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| المؤلفون: | Lluís, Núria, Serradilla-Martín, Mario, Achalandabaso, Mar, Jehaes, François, Dasari, Bobby V M, Mambrilla-Herrero, Sara, Sparrelid, Ernesto, Balakrishnan, Anita, Hoogwater, Frederik J H, Amaral, Maria João, Andersson, Bodil, Berrevoet, Frederik, Doussot, Alexandre, López-López, Víctor, Alsammani, Mohammedsuror, Detry, Olivier, Domingo-Del Pozo, Carlos, Machairas, Nikolaos, Pekli, Damján, Alcázar-López, Cándido F, Asbun, Horacio, Björnsson, Bergthor, Christophides, Thalis, Díez-Caballero, Alberto, Francart, David, Noel, Colin B, Sousa-Silva, Donzília, Toledo-Martínez, Enrique, Tzimas, George N, Yaqub, Sheraz, Cauchy, François, Prieto-Calvo, Mikel, D'Souza, Melroy A, Spiers, Harry V M, van den Heuvel, Marius C, Charco, Ramón, Lesurtel, Mickaël, Ramia, José Manuel, Research and Scientific committee of the E-AHPBA |
| المصدر: | International Journal of Surgery, 109 (4), 760-771 (2023-04-15) |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | cancer, foie, chirurgie, cholangiocarcinome, adenocarcinome, Human health sciences, Surgery, Oncology, Sciences de la santé humaine, Chirurgie, Oncologie |
| الوصف: | [en] BACKGROUND/PURPOSE: Intraductal papillary neoplasm of the bile duct (IPNB) is a rare disease in Western countries. The main aim of this study was to characterize current surgical strategies and outcomes in the mainly European participating centers.METHODS: A multi-institutional retrospective series of patients with a diagnosis of IPNB undergoing surgery between January 1, 2010, and December 31, 2020 was gathered under the auspices of the E-AHPBA. Textbook outcome was defined as non-prolonged length of hospital stay plus absence of any Clavien-Dindo grade ≥III complication, readmission, or mortality within 90 postoperative days.RESULTS: A total of 28 centers contributed 85 patients who underwent surgery for IPNB. Median age was 66 years (55-72), 49.4% were women and 87.1% Caucasian. Open surgery was performed in 72 patients (84.7%), laparoscopic in 13 (15.3%). Textbook outcome was achieved in 54.1% of patients, reaching 63.8% after liver resection, and 32.0% after pancreas resection. Median overall survival was 5.72 years, with 5-year overall survival of 63% (95% CI 50-82). Overall survival was better in patients with Charlson comorbidity score ≤4 versus >4 (P=0.016), intra- versus extra-hepatic tumor (P=0.027), single versus multiple tumor (P=0.007), those who underwent hepatic versus pancreatic resection (P=0.017), or achieved versus failed textbook outcome (P=0.029). Multivariable Cox regression analysis showed that not achieving textbook outcome (HR 4.20, 95% CI 1.11-15.94, P=0.03) was an independent prognostic factor of poor overall survival.CONCLUSIONS: Patients undergoing liver resection for IPNB were more likely to achieve a textbook outcome than those requiring a pancreatic resection. Comorbidity, tumor location and tumor multiplicity influenced overall survival. Textbook outcome was an independent prognostic factor of overall survival. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article peer reviewed |
| اللغة: | English |
| العلاقة: | urn:issn:1743-9191; urn:issn:1743-9159 |
| DOI: | 10.1097/JS9.0000000000000280 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/300819Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.300819 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1097/JS9.0000000000000280 |
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