دورية أكاديمية
Renal Oncocytoma: The Diagnostic Challenge to Unmask the Double of Renal Cancer
| العنوان: | Renal Oncocytoma: The Diagnostic Challenge to Unmask the Double of Renal Cancer |
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| المؤلفون: | Francesco Trevisani, Matteo Floris, Roberto Minnei, Alessandra Cinque |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 5, p 2603 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | oncocytoma, molecular profiling, renal function, molecular biomarkers, diagnosis, treatment, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Renal oncocytoma represents the most common type of benign neoplasm that is an increasing concern for urologists, oncologists, and nephrologists due to its difficult differential diagnosis and frequent overtreatment. It displays a variable neoplastic parenchymal and stromal architecture, and the defining cellular element is a large polygonal, granular, eosinophilic, mitochondria-rich cell known as an oncocyte. The real challenge in the oncocytoma treatment algorithm is related to the misdiagnosis due to its resemblance, at an initial radiological assessment, to malignant renal cancers with a completely different prognosis and medical treatment. Unfortunately, percutaneous renal biopsy is not frequently performed due to the possible side effects related to the procedure. Therefore, the majority of oncocytoma are diagnosed after the surgical operation via partial or radical nephrectomy. For this reason, new reliable strategies to solve this issue are needed. In our review, we will discuss the clinical implications of renal oncocytoma in daily clinical practice with a particular focus on the medical diagnosis and treatment and on the potential of novel promising molecular biomarkers such as circulating microRNAs to distinguish between a benign and a malignant lesion. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/23/5/2603Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms23052603 |
| الوصول الحر: | https://doaj.org/article/37bff2ddc58b4e6698418a2c708538eeTest |
| رقم الانضمام: | edsdoj.37bff2ddc58b4e6698418a2c708538ee |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms23052603 |