دورية أكاديمية
Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism
| العنوان: | Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism |
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| المؤلفون: | Ekaterina E. Bibik, Anna K. Eremkina, Julia A. Krupinova, Natalia V. Klementieva, Ekaterina A. Dobreva, Natalia G. Mokrysheva |
| المصدر: | Сахарный диабет, Vol 23, Iss 5, Pp 459-466 (2021) |
| بيانات النشر: | Endocrinology Research Centre |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | primary hyperparathyroidism, parathyroid hormone, hypercalcemia, diabetes mellitus, insulin resistance, obesity, dyslipidemia, hyperuricemia, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | The clinical picture of primary hyperparathyroidism (PHPT) which caused by parathyroid neoplasms often includes metabolic syndrome leading to the development of cardiovascular diseases. According to clinical studies, an increased incidence of diabetes mellitus, insulin resistance, obesity, dyslipidemia, hyperuricemia and other disorders that signifi tly affect the life span and quality are observed in patients with PHPT regardless of the form and the severity of the underlying disease. Basic research shows the potential nonclassical effects of high levels of parathyroid hormone and calcium on adipose tissue, pancreas, gastrointestinal tract and kidneys. However, the pathogenetic mechanisms of impaired carbohydrate and other types of metabolism in patients with parathyroid hyperfunction remain unclear because of the lack of relevant experimental models and the heterogeneity of patient groups. Besides, the effect of surgery on metabolic abnormalities is also controversial. Nowadays a deeper understanding of this issue is required, which can subsequently help in the creation of optimal approach to diagnosis and treatment of patients. This review covers different aspects of metabolic disorders in patients with PHPT, as well as potential key factors of their development. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English Russian |
| تدمد: | 2072-0351 2072-0378 |
| العلاقة: | https://www.dia-endojournals.ru/jour/article/view/12436Test; https://doaj.org/toc/2072-0351Test; https://doaj.org/toc/2072-0378Test; https://doaj.org/article/648637706a8547879ee395ca19a207d6Test |
| DOI: | 10.14341/DM12436 |
| الإتاحة: | https://doi.org/10.14341/DM12436Test https://doaj.org/article/648637706a8547879ee395ca19a207d6Test |
| رقم الانضمام: | edsbas.AE9043F9 |
| قاعدة البيانات: | BASE |
| تدمد: | 20720351 20720378 |
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| DOI: | 10.14341/DM12436 |