التفاصيل البيبلوغرافية
| العنوان: |
Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms. |
| المؤلفون: |
Ide, S., Kobayashi, H., Ujike, H., Ozaki, N., Sekine, Y., Inada, T., Harano, M., Komiyama, T., Yamada, M., Iyo, M., Iwata, N., Tanaka, K., Shen, H., Iwahashi, K., Itokawa, M., Minami, M., Satoh, M., Ikeda, K., Sora, I. |
| المصدر: |
Pharmacogenomics Journal; 2006, Vol. 6 Issue 3, p179-188, 10p, 1 Diagram, 5 Charts |
| مصطلحات موضوعية: |
METHAMPHETAMINE abuse, PSYCHOSES, OPIOID receptors, GENETIC polymorphisms, NUCLEOTIDES |
| مستخلص: |
Several studies indicate that the μ-opioid receptor plays a role in addiction not only to opiate drugs but also to alcohol and non-opiate addictive drugs. Our studies aim to reveal the associations between gene polymorphisms and methamphetamine (MAP) dependence/psychosis. We newly identified several polymorphisms and four substantial linkage disequilibrium (LD) blocks in the μ-opioid receptor (OPRM1) gene. We found significant differences in both genotype and allele frequencies of the single-nucleotide polymorphism (SNP) IVS2+G691C between control (n=232) and MAP-dependent/psychotic patients (n=128). There was also a significant association between IVS2+G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis.The Pharmacogenomics Journal (2006) 6, 179–188. doi:10.1038/sj.tpj.6500355; published online 10 January 2006 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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