التفاصيل البيبلوغرافية
| العنوان: |
Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture. |
| المؤلفون: |
Zhao-Ying Ding1, Ying-Hsuan Wang1, Yu-Cheng Huang1, Myong-Chol Lee1, Min-Jen Tseng1, Min-Lang Huang1, Ya-Hui Chi2 |
| المصدر: |
Journal of Cell Biology. Sep2017, Vol. 216 Issue 9, p2827-2841. 15p. |
| مصطلحات موضوعية: |
*NUCLEAR membranes, *NUCLEAR matrix, *DROSOPHILA melanogaster |
| مستخلص: |
Linker of nucleoskeleton and cytoskeleton (LINC) complexes spanning the nuclear envelope (NE) contribute to nucleocytoskeletal force transduction. A few NE proteins have been found to regulate the LINC complex. In this study, we identify one, Kuduk (Kud), which can reside at the outer nuclear membrane and is required for the development of Drosophila melanogaster ovarian follicles and NE morphology of myonuclei. Kud associates with LINC complex components in an evolutionarily conserved manner. Loss of Kud increases the level but impairs functioning of the LINC complex. Overexpression of Kud suppresses NE targeting of cytoskeleton-free LINC complexes. Thus, Kud acts as a quality control mechanism for LINC-mediated nucleocytoskeletal connections. Genetic data indicate that Kud also functions independently of the LINC complex. Overexpression of the human orthologue TMEM258 in Drosophila proved functional conservation. These findings expand our understanding of the regulation of LINC complexes and NE architecture. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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