دورية أكاديمية
Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification
| العنوان: | Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification |
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| المؤلفون: | Leader, Andrew, Grout, John, Maier, Barbara, Nabet, Barzin, Park, Matthew, Tabachnikova, Alexandra, Chang, Christie, Walker, Laura, Lansky, Alona, Le Berichel, Jessica, Troncoso, Leanna, Malissen, Nausicaa, Davila, Melanie, Martin, Jerome, Magri, Giuliana, Tuballes, Kevin, Zhao, Zhen, Petralia, Francesca, Samstein, Robert, D’amore, Natalie Roy, Thurston, Gavin, Kamphorst, Alice, Wolf, Andrea, Flores, Raja, Wang, Pei, Müller, Sören, Mellman, Ira, Beasley, Mary Beth, Salmon, Hélène, Rahman, Adeeb, Marron, Thomas, Kenigsberg, Ephraim, Merad, Miriam |
| المساهمون: | Icahn School of Medicine at Mount Sinai New York (MSSM), Genentech, Inc. San Francisco, Service de dermatologie, vénéreologie et cancérologie cutanée Hôpital de la Timone - APHM, Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Timone CHU - APHM (TIMONE), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Immunologie CHU Nantes, Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Team 1 : Mononuclear phagocytes, Immunopathology, Immunovirology (Team 1 - U1064 Inserm - CR2TI), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Takeda Pharmaceutical Co., Ltd. Tokyo, Japan (TPC), Regeneron Pharmaceuticals Inc. Tarrytown, NY, USA (RPI), R56 AI137244/AI/NIAID NIH HHS/United StatesT32 CA078207/CA/NCI NIH HHS/United StatesU24 CA210993/CA/NCI NIH HHS/United StatesR01 CA257195/CA/NCI NIH HHS/United StatesR01 CA254104/CA/NCI NIH HHS/United StatesU24 AI118644/AI/NIAID NIH HHS/United States |
| المصدر: | ISSN: 1535-6108 ; Cancer Cell ; https://inserm.hal.science/inserm-04251063Test ; Cancer Cell, 2021, 39 (12), pp.1594-1609.e12. ⟨10.1016/j.ccell.2021.10.009⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | Aix-Marseille Université: HAL |
| مصطلحات موضوعية: | CITEseq, NSCLC, dendritic cells, high dimensional profiling, immunotherapy, macrophages, tumor cell atlas, tumor microenvironment, tumor mutational burden, tumor-associated myeloid cells, MESH: Carcinoma, Non-Small-Cell Lung / immunology, MESH: Humans, MESH: Immunotherapy / methods, MESH: Lung Neoplasms / immunology, MESH: Single-Cell Analysis / methods, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Immunotherapy is a mainstay of non-small cell lung cancer (NSCLC) management. While tumor mutational burden (TMB) correlates with response to immunotherapy, little is known about the relationship between the baseline immune response and tumor genotype. Using single-cell RNA sequencing, we profiled 361,929 cells from 35 early-stage NSCLC lesions. We identified a cellular module consisting of PDCD1+CXCL13+ activated T cells, IgG+ plasma cells, and SPP1+ macrophages, referred to as the lung cancer activation module (LCAMhi). We confirmed LCAMhi enrichment in multiple NSCLC cohorts, and paired CITE-seq established an antibody panel to identify LCAMhi lesions. LCAM presence was found to be independent of overall immune cell content and correlated with TMB, cancer testis antigens, and TP53 mutations. High baseline LCAM scores correlated with enhanced NSCLC response to immunotherapy even in patients with above median TMB, suggesting that immune cell composition, while correlated with TMB, may be a nonredundant biomarker of response to immunotherapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34767762; inserm-04251063; https://inserm.hal.science/inserm-04251063Test; https://inserm.hal.science/inserm-04251063/documentTest; https://inserm.hal.science/inserm-04251063/file/1-s2.0-S1535610821005602-main.pdfTest; PUBMED: 34767762; PUBMEDCENTRAL: PMC8728963 |
| DOI: | 10.1016/j.ccell.2021.10.009 |
| الإتاحة: | https://doi.org/10.1016/j.ccell.2021.10.009Test https://inserm.hal.science/inserm-04251063Test https://inserm.hal.science/inserm-04251063/documentTest https://inserm.hal.science/inserm-04251063/file/1-s2.0-S1535610821005602-main.pdfTest |
| رقم الانضمام: | edsbas.CB7373C1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ccell.2021.10.009 |
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