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المصدر: Molecules, Vol 24, Iss 19, p 3593 (2019)
Moleculesمصطلحات موضوعية: 0301 basic medicine, Pharmaceutical Science, sulforaphane, Disease, Review, Bioinformatics, Analytical Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Anti-Infective Agents, Isothiocyanates, Drug Discovery, Medicine, nrf2, Glucoraphanin, Clinical Trials as Topic, Molecular Structure, 3. Good health, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Sulfoxides, Chemoprotective, Molecular Medicine, allometric scaling, chemoprotection, Brassica, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, Biomarkers, Tumor, Animals, Humans, Microbiome, Physical and Theoretical Chemistry, broccoli, clinical trials, business.industry, Plant Extracts, glucoraphanin, Organic Chemistry, myrosinase, toxicity, Antineoplastic Agents, Phytogenic, Bioavailability, Clinical trial, 030104 developmental biology, chemistry, Isothiocyanate, business, Sulforaphane
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b2496ac3653b236a87628394c1f7d0Test
https://www.mdpi.com/1420-3049/24/19/3593Test -
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المؤلفون: Jennifer E. Gallagher, Dorothy Kisielewski, John F. Dillon, Shaun V. Walsh, Diane Cassidy, David J. Harrison, Ritu Sharma, Tadashi Honda, John D. Hayes, Alison D. McNeilly, Michael L.J. Ashford, Albena T. Dinkova-Kostova, Rory J. McCrimmon
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 367-398 (2018)مصطلحات موضوعية: NQO1, NAD(P)H:quinone oxidoreductase 1, TNF-α, tumor necrosis factor-α, IRE1α, inositol requiring kinase-1α, SCAD, short-chain acyl-CoA dehydrogenase, C/EBP, CCAAT/enhancer-binding protein, PCR, polymerase chain reaction, UPR, unfolded protein response, 0302 clinical medicine, Fibrosis, MGPAT, mitochondrial glycerol-3-phosphate acetyltransferase, ATF4, activating transcription factor-4, DGAT2, diacylglycerol acyltransferase-2, LXRα, liver X receptor α, Glucose homeostasis, eIf2α, eukaryotic translation initiation factor 2A, IKK, IκB kinase, ACOT7, acetyl-CoA thioesterase 7, Original Research, TGFβ, transforming growth factor beta-1, SLC7A11, solute carrier family 7 member 11, GSSG, oxidized glutathione, MTTP, microsomal triglyceride transfer protein, NASH, Gastroenterology, TXN1, thioredoxin-1, 3. Good health, ChREBP, carbohydrate-responsive element-binding protein, 030220 oncology & carcinogenesis, NASH, nonalcoholic steatohepatitis, medicine.medical_specialty, PARP, poly ADP ribose polymerase, qRT-PCR, quantitative reverse transcriptase PCR, GSTM1, glutathione S-transferase Mu-1, GCLC, glutamate-cysteine ligase catalytic, Nrf2, ACACA, acetyl-CoA carboxylase alpha, 03 medical and health sciences, FXR, farnesoid X receptor, Nrf2, NF-E2 p45-related factor 2, COX2, cyclooxygenase-2, Keap1, Kelch-like ECH-associated protein-1, PPARα, peroxisome proliferator-activated receptor α, PTT, pyruvate tolerance test, HMOX1, heme oxygenase-1, RC, regular chow, p58IPK, p58 inhibitor of the PKR kinase, medicine.disease, TBE-31, 030104 developmental biology, Endocrinology, COL1A1, collagen, type I, alpha-1, Unfolded protein response, CAT, catalase, 0301 basic medicine, PDI, protein disulfide isomerase, GSH, reduced glutathione, FASN, fatty acid synthase, BCL-2, B-cell lymphoma, MPO, myeloperoxidase, AP-1, activator protein 1, DMSO, dimethyl sulfoxide, medicine.disease_cause, SHP, small heterodimer partner, CDDO, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid, CHOP, C/EBP homologous protein, TXNRD1, thioredoxin reductase-1, HF30Fr, high-fat diet with 30% fructose in drinking water, IκB, inhibitor of NF-κB, SFN, sulforaphane, ADRP, adipose differentiation-related protein, NAS, NAFLD activity score, GPX2, glutathione peroxidase-2, Chemistry, MCP-1, monocyte chemotactic protein-1, XBP1, X-box binding protein-1, SREBP-1c, sterol regulatory element-binding protein-1c, Lipogenesis, GTT, glucose tolerance test, PERK, PRK-like endoplasmic reticulum kinase, PTGR1, prostaglandin reductase-1, GSTA4, glutathione S-transferase Alpha-4, medicine.symptom, NAFLD, non-alcoholic fatty liver disease, α-SMA, alpha smooth muscle actin, ACOX2, acetyl-CoA oxidase 2, HFFr, high-fat diet with fructose in drinking water, NF-κB, nuclear factor-κB, GCLM, glutamate-cysteine ligase modifier, Inflammation, JNK1, c-Jun N-terminal kinase 1, CD36, cluster of differentiation 36, ER, endoplasmic reticulum, Insulin resistance, HF, high-fat, HF55Fr, high-fat diet with 55% fructose in drinking water, Internal medicine, ATF6, activating transcription factor-6, medicine, ApoB, apolipoprotein B, lcsh:RC799-869, CES1G, carboxylesterase 1g, ITT, insulin tolerance test, MCD, methionine- and choline-deficient, ACLY, ATP citrate lyase, Hepatology, SCD1, stearoyl-CoA desaturase-1, NOS2, nitric oxide synthase-2, PRDX6, peroxiredoxin 6, PPARγ, peroxisome proliferator-activated receptor γ, BIP, binding immunoglobulin protein, H&E, hematoxylin and eosin, lcsh:Diseases of the digestive system. Gastroenterology, Steatosis, CPT1A, carnitine palmitoyltransferase 1a, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdd8de56b5ba950a8c970d72cce7012Test
https://doi.org/10.1016/j.jcmgh.2017.11.016Test -
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المؤلفون: Luke A. J. O'Neill, Dave Speijer, Esther Lutgens, Michel van Weeghel, Annette E. Neele, Koen H.M. Prange, Saskia van der Velden, Albena T. Dinkova-Kostova, Menno P.J. de Winther, Rob C. I. Wüst, Jeroen Baardman, Maarten E. Witte, Simone Denis, Jan Van den Bossche, Elena V. Knatko, Dylan G. Ryan, Sanne G.S. Verberk, Riekelt H. Houtkooper
المساهمون: Molecular cell biology and Immunology, Physiology, Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Atherosclerosis & ischemic syndromes, Graduate School, Medical Biochemistry, AII - Inflammatory diseases, Laboratory Genetic Metabolic Diseases, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, AMS - Ageing & Morbidty, ACS - Amsterdam Cardiovascular Sciences, AII - Amsterdam institute for Infection and Immunity, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Aging & Later Life, AGEM - Endocrinology, metabolism and nutrition, AGEM - Inborn errors of metabolism, ARD - Amsterdam Reproduction and Development
المصدر: Cell Reports, 25(8), 2044-2052.e5. Cell Press
Baardman, J, Verberk, S G S, Prange, K H M, van Weeghel, M, van der Velden, S, Ryan, D G, Wüst, R C I, Neele, A E, Speijer, D, Denis, S W, Witte, M E, Houtkooper, R H, O'neill, L A, Knatko, E V, Dinkova-Kostova, A T, Lutgens, E, de Winther, M P J & Van den Bossche, J 2018, ' A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia ', Cell Reports, vol. 25, no. 8, pp. 2044-2052.e5 . https://doi.org/10.1016/j.celrep.2018.10.092Test, https://doi.org/10.1016/j.celrep.2018.10.092Test
Cell reports, 25(8), 2044-2052. Cell Press
Cell Reports, Vol 25, Iss 8, Pp 2044-2052.e5 (2018)
Baardman, J, Verberk, S G S, Prange, K H M, van Weeghel, M, van der Velden, S, Ryan, D G, Wüst, R C I, Neele, A E, Speijer, D, Denis, S W, Witte, M E, Houtkooper, R H, O'neill, L A, Knatko, E V, Dinkova-Kostova, A T, Lutgens, E, de Winther, M P J & Van den Bossche, J 2018, ' A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia ', Cell Reports, vol. 25, no. 8, pp. 2044-2052.e5 . https://doi.org/10.1016/j.celrep.2018.10.092Testمصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, NF-E2-Related Factor 2, Citric Acid Cycle, immunometabolism, pentose phosphate pathway, Inflammation, Pentose phosphate pathway, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Nrf2, 03 medical and health sciences, 0302 clinical medicine, Immune system, SDG 3 - Good Health and Well-being, cardiovascular disease, medicine, Macrophage, Animals, lcsh:QH301-705.5, hypercholesterolemia, Chemistry, meta-inflammation, Metabolism, metabolic disease, foam cells, Cell biology, macrophages, Mice, Inbred C57BL, 030104 developmental biology, Cell metabolism, lcsh:Biology (General), inflammation, 030220 oncology & carcinogenesis, Cytokine secretion, Female, medicine.symptom, atherosclerosis, Glycolysis, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ef415f4ba7df2f11e9a8a4f10fe79fTest
https://research.vumc.nl/en/publications/18d3e0ec-b7da-4ccb-bcdd-e585bd6780daTest -
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المصدر: Phytomedicine
مصطلحات موضوعية: NF-E2-Related Factor 2, Pharmaceutical Science, Cellular homeostasis, KEAP1, Kelch-like ECH-associated protein 1, NRF2, nuclear factor erythroid 2 p45-related factor 2, HDAC, histone deacetylase, BITC, benzyl isothiocyanate, NRF2, 03 medical and health sciences, chemistry.chemical_compound, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Isothiocyanates, Cell Line, Tumor, Drug Discovery, Animals, Humans, Kinase activity, AMPK, 5′-AMP-activated protein kinase, PI3K-AKT, phosphatidylinositol 3-kinase-AKT/protein kinase B, Phosphorylation, Protein kinase A, Protein kinase B, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, 030304 developmental biology, SFN, sulforaphane, Pharmacology, 0303 health sciences, biology, NRF2, nuclear factor erythroid 2 p45-related factor 2, Chemistry, PI3K-AKT, mTOR, mechanistic target of rapamycin, TOR Serine-Threonine Kinases, HDAC6, Cell biology, Complementary and alternative medicine, 030220 oncology & carcinogenesis, Sulfoxides, biology.protein, mTOR, Molecular Medicine, Original Article, Sulforaphane, CBHA, m-carboxycinnamic acid bis-hydroxamide, Proto-Oncogene Proteins c-akt
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af06445f4431c6648c6a7e5f775d427Test
http://europepmc.org/articles/PMC8106549Test -
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المؤلفون: Albena T. Dinkova-Kostova, Filip Cvetko, Hiran A. Prag, Michael P. Murphy, Stuart T. Caldwell, Maureen Higgins, Takafumi Suzuki, Richard C. Hartley, Masayuki Yamamoto
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, GCLC, glutamate–cysteine ligase catalytic subunit, thiol oxidation, Mitochondrion, Biochemistry, FB, fractionation buffer, NQO1, NAD(P)H:quinone oxidoreductase-1, Mice, chemistry.chemical_compound, DNM1L, Superoxides, energy metabolism, Homeostasis, Hydrogen peroxide, Cells, Cultured, HO-1, heme oxygenase-1, NAC, N-acetyl-L-cysteine, SFN, sulforaphane, chemistry.chemical_classification, Kelch-Like ECH-Associated Protein 1, Nrf2, nuclear factor erythroid 2–related factor 2, respiratory system, DRP1, dynamin-related protein 1, Glutathione, Mitochondria, Cell biology, CDNB, 1-chloro-2,4-dinitrobenzene, Keap1, Kelch-like ECH-associated protein 1, TRX, thioredoxin, Thioredoxin, Oxidation-Reduction, Research Article, Signal Transduction, NF-E2-Related Factor 2, reactive oxygen species (ROS), Nrf2, MitoPQ, MitoParaquat, 03 medical and health sciences, MitoCDNB, CD, concentration required to double, ROS, reactive oxygen species, PGAM5, phosphoglycerate mutase family member 5, Animals, TRXR2, TRX reductase 2, Cysteine, Sulfhydryl Compounds, redox signaling, Molecular Biology, Reactive oxygen species, 030102 biochemistry & molecular biology, Cell Biology, ACN, acetonitrile, MitoCDNB, MitoChlorodinitrobenzoic acid, GSS, GSH synthetase, MEF, mouse embryonic fibroblast, KEAP1, 030104 developmental biology, chemistry, BSA, bovine serum albumin, MitoPQ
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0523882756133409621203d90cd5225Test
https://doi.org/10.1074/jbc.ra120.016551Test -
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المؤلفون: Albena T. Dinkova-Kostova, Jean A. Quinn, Joanne Edwards, Laura Casares, Gunjit Maan, Laura Torrente, Angus W. Jackson, Silvio Bicciato, Ying Zhang, Jani Saarela, Laureano de la Vega, Evgeny Kulesskiy, Asma Oumkaltoum Rezig, Andrea Grilli
المساهمون: Institute for Molecular Medicine Finland, University of Helsinki, Biosciences
المصدر: Biomolecules, Vol 10, Iss 1365, p 1365 (2020)
Biomoleculesمصطلحات موضوعية: 0301 basic medicine, POTENT AURORA KINASE, Colorectal cancer, Drug Evaluation, Preclinical, lcsh:QR1-502, environment and public health, Biochemistry, lcsh:Microbiology, NEGATIVE REGULATION, PATHWAY, 0302 clinical medicine, Urea, Medicine, Drug screening, NRF2, SMALL-MOLECULE INHIBITOR, Hyperactivation, Kinase, Communication, TUMOR-GROWTH, respiratory system, 3. Good health, Gene Expression Regulation, Neoplastic, PHASE-I, 030220 oncology & carcinogenesis, Colorectal Neoplasms, Signal Transduction, EXPRESSION, Cell Survival, NF-E2-Related Factor 2, In silico, Aurora inhibitor, colorectal cancer, digestive system, 03 medical and health sciences, Downregulation and upregulation, Cell Line, Tumor, Humans, LUNG-CARCINOMA, drug screening, Protein Kinase Inhibitors, Molecular Biology, Cell Proliferation, business.industry, medicine.disease, KEAP1, 030104 developmental biology, Drug Resistance, Neoplasm, Cell culture, Cancer cell, Cancer research, 1182 Biochemistry, cell and molecular biology, Benzimidazoles, 3111 Biomedicine, business, RESISTANCE
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db5a8ccdf6881c79812ba3a75b4bdf6Test
https://doi.org/10.3390/biom10101365Test -
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المؤلفون: Ali Gorji, Albena T Dinkova Kostova, Stjepana Kovac, Nico Melzer, Sven G. Meuth, Alexander M. Herrmann
المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 9, p 1935 (2017)مصطلحات موضوعية: 0301 basic medicine, Review, Pharmacology, Mitochondrion, medicine.disease_cause, Endoplasmic Reticulum, Epileptogenesis, lcsh:Chemistry, Epilepsy, 0302 clinical medicine, Adenosine Triphosphate, Calcium dynamics, Homeostasis, lcsh:QH301-705.5, Spectroscopy, chemistry.chemical_classification, reactive oxygen species, Cell Death, Acquired epilepsy, General Medicine, Computer Science Applications, Mitochondria, NF-E2-Related Factor 2, Biology, Catalysis, Nrf2, Inorganic Chemistry, 03 medical and health sciences, Seizures, medicine, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, Reactive oxygen species, calcium, Research, Organic Chemistry, Cell Membrane, medicine.disease, Oxidative Stress, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, chemistry, Calcium Channels, Energy Metabolism, Neuroscience, 030217 neurology & neurosurgery, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b99ddf0d7d6afa74ce83f70daa6f9dTest
https://pubmed.ncbi.nlm.nih.gov/28885567Test -
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المؤلفون: Lenka, Roubalová, Albena T, Dinkova-Kostova, David, Biedermann, Vladimír, Křen, Jitka, Ulrichová, Jiří, Vrba
المصدر: Fitoterapia
مصطلحات موضوعية: NF-E2-Related Factor 2, Glutamate-Cysteine Ligase, NQO1, NAD(P)H:quinone oxidoreductase 1, Gene Expression, ARE, antioxidant response element, Gapdh, glyceraldehyde-3-phosphate dehydrogenase, DMSO, dimethyl sulfoxide, SC, silychristin, Article, Nrf2, DHSD, 2,3-dehydrosilydianin, SB, silybin, Mice, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Silybum marianum, ROS, reactive oxygen species, Cell Line, Tumor, NAD(P)H Dehydrogenase (Quinone), Nrf2/NFE2L2, NF-E2 p45-related factor 2, Animals, Humans, Milk Thistle, DHSC, 2,3-dehydrosilychristin, SFN, sulforaphane, Molecular Structure, HMOX1, heme oxygenase-1, Membrane Proteins, SD, silydianin, GCLM, glutamate-cysteine ligase modifier subunit, Up-Regulation, Keap1, Kelch-like ECH-associated protein 1, Flavonolignans, Silybin, NQO1, DHSB, 2,3-dehydrosilybin, Heme Oxygenase-1, GCLC, glutamate-cysteine ligase catalytic subunit, Silymarin
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::99487d2bc78654f7342479f183a8f101Test
https://pubmed.ncbi.nlm.nih.gov/28450126Test -
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المؤلفون: Lenka, Roubalová, David, Biedermann, Barbora, Papoušková, Jan, Vacek, Marek, Kuzma, Vladimír, Křen, Jitka, Ulrichová, Albena T, Dinkova-Kostova, Jiří, Vrba
المصدر: Chemico-Biological Interactions
مصطلحات موضوعية: Cell Survival, NF-E2-Related Factor 2, NQO1, NAD(P)H:quinone oxidoreductase 1, Methyl gallate, ARE, antioxidant response element, Gapdh, glyceraldehyde-3-phosphate dehydrogenase, DMSO, dimethyl sulfoxide, p38 Mitogen-Activated Protein Kinases, Mass Spectrometry, Article, Nrf2, Mice, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, ROS, reactive oxygen species, ERK, extracellular signal-regulated kinase, Genes, Reporter, Cell Line, Tumor, Quercetin-7-gallate, HO-1/Hmox1, heme oxygenase-1, NAD(P)H Dehydrogenase (Quinone), Animals, Humans, heterocyclic compounds, Nrf2, NF-E2 p45-related factor 2, Protein Kinase Inhibitors, Biotransformation, NAC, N-acetyl-l-cysteine, GCLM, glutamate-cysteine ligase modifier subunit, Keap1, Kelch-like ECH-associated protein 1, RAW 264.7 Cells, Metabolism, Gene Expression Regulation, Heme oxygenase-1, Enzyme Induction, JNK, c-Jun N-terminal kinase, Metabolome, p38 MAPK, p38 mitogen-activated protein kinase, Quercetin, Reactive Oxygen Species, GCLC, glutamate-cysteine ligase catalytic subunit, MAPK, mitogen-activated protein kinase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::7e6fbf86ca95d28c7e05d0f312bfa175Test
https://pubmed.ncbi.nlm.nih.gov/27777014Test -
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المؤلفون: Kusal T. G. Samarasinghe, Young Hoon Ahn, Philip A. Cole, Ying Zhang, A. Pheely, G. C. Van Hecke, Albena T. Dinkova-Kostova, Ivor J. Benjamin, Robert N. Cole, Tatiana Boronina, S. Dayalan Naidu
المصدر: British Journal of Cancer
مصطلحات موضوعية: Cancer Research, Molecular Sequence Data, Hsp90, Breast Neoplasms, HSP72 Heat-Shock Proteins, Cell Growth Processes, Biology, HSF1, NRF2, Hsp90 inhibitor, Mice, 03 medical and health sciences, chemistry.chemical_compound, Adenosine Triphosphate, 0302 clinical medicine, Cell Line, Tumor, Heat shock protein, Animals, Humans, Amino Acid Sequence, Cysteine, HSP90 Heat-Shock Proteins, Molecular Targeted Therapy, Sulfhydryl Compounds, Cysteine metabolism, 030304 developmental biology, Mice, Knockout, 0303 health sciences, Neoplasm Proteins, Up-Regulation, 3. Good health, Proteostasis, Oncology, chemistry, Biochemistry, Sulfoxides, 030220 oncology & carcinogenesis, Chaperone (protein), MCF-7 Cells, biology.protein, Female, Carbamates, Translational Therapeutics, HeLa Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1597f50dd6ab1eaf2bac1a922b2242adTest
https://doi.org/10.1038/bjc.2013.710Test