دورية أكاديمية
Magnetically Assisted Drug Delivery of Topical Eye Drops Maintains Retinal Function In Vivo in Mice.
| العنوان: | Magnetically Assisted Drug Delivery of Topical Eye Drops Maintains Retinal Function In Vivo in Mice. |
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| المؤلفون: | Bassetto, Marco, Ajoy, Daniel, Poulhes, Florent, Obringer, Cathy, Walter, Aurelie, Messaddeq, Nadia, Sadeghi, Amir, Puranen, Jooseppi, Ruponen, Marika, Kettunen, Mikko, Toropainen, Elisa, Urtti, Arto, Dollfus, Hélène, Zelphati, Olivier, Marion, Vincent |
| المساهمون: | Laboratoire de Génétique Médicale (LGM), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Eastern Finland, Institut de génétique médicale d’Alsace (IGMA), Les Hôpitaux Universitaires de Strasbourg (HUS), 722717 |
| المصدر: | ISSN: 1999-4923 ; Pharmaceutics ; https://hal.science/hal-03701314Test ; Pharmaceutics, 2021, 13 (10), ⟨10.3390/pharmaceutics13101650⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2021 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | Bardet Biedl syndrome, magnetic nanoparticles, magnetic targeting, non-invasive, retinal degeneration, small drug molecules, topical drug delivery, unfolded protein response, [SDV.BC]Life Sciences [q-bio]/Cellular Biology |
| الوصف: | Barded-Biedl syndrome (BBS) is a rare genetic disorder with an unmet medical need for retinal degeneration. Small-molecule drugs were previously identified to slow down the apoptosis of photoreceptors in BBS mouse models. Clinical translation was not practical due to the necessity of repetitive invasive intravitreal injections for pediatric populations. Non-invasive methods of retinal drug targeting are a prerequisite for acceptable adaptation to the targeted pediatric patient population. Here, we present the development and functional testing of a non-invasive, topical, magnetically assisted delivery system, harnessing the ability of magnetic nanoparticles (MNPs) to cargo two drugs (guanabenz and valproic acid) with anti-unfolded protein response (UPR) properties towards the retina. Using magnetic resonance imaging (MRI), we showed the MNPs' presence in the retina of Bbs wild-type mice, and their photoreceptor localization was validated using transmission electron microscopy (TEM). Subsequent electroretinogram recordings (ERGs) demonstrated that we achieved beneficial biological effects with the magnetically assisted treatment translating the maintained light detection in Bbs-/- mice (KO). To our knowledge, this is the first demonstration of efficient magnetic drug targeting in the photoreceptors in vivo after topical administration. This non-invasive, needle-free technology expands the application of SMDs for the treatment of a vast spectrum of retinal degenerations and other ocular diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34683941; hal-03701314; https://hal.science/hal-03701314Test; PUBMED: 34683941; PUBMEDCENTRAL: PMC8540400 |
| DOI: | 10.3390/pharmaceutics13101650 |
| الإتاحة: | https://doi.org/10.3390/pharmaceutics13101650Test https://hal.science/hal-03701314Test |
| رقم الانضمام: | edsbas.2D2D50C1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/pharmaceutics13101650 |
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