المؤلفون: Miller, Anne-Frances, Park, Jonathan T., Ferguson, Kyle L., Pitsawong, Warintra, Bommarius, Andreas S.

المصدر: Chemistry Faculty Publications

مصطلحات موضوعية: nitroreductase, flavoenzyme, enzyme-aided synthesis, structure-activity, structure-function, intertwined dimer, domain-swapped dimer, flavin, Amines, Binding Sites, Biosynthetic Pathways, Fermentation, Models, Molecular, Molecular Conformation, Molecular Structure, NAD, Nitroreductases, Oxidation-Reduction, Protein Binding, Structure-Activity Relationship, Substrate Specificity, Biochemistry, Biophysics, and Structural Biology, Chemistry, Pharmacy and Pharmaceutical Sciences

وصف الملف: application/pdf

العلاقة: Supplementary Materials: The following are available online, four tables providing (1,2) lists of compounds studied, (3) surface areas buried in the NR dimers and (4) list of all NR structures and sequences used. Nine figures providing (1) sequence similarity network, (2) calibration and validation of E° c calculations, (3) dependence of amine formation on electron withdrawal (E° c ), substrate volume or log(P), (4) dependence of rate constants on substituent constants, (5) sequential identification of NR subgroups on the basis of distinguishing structure, (6) numbering of the positions of the flavin right, and that of NADH, (7) comparisons of the shapes and sizes of the different subgroups’ active sites, (8) distribution of amino acid conservation in the structure, and (9) a multiple sequence alignment of the NRs whose structures were compared as well as supporting sequences.; https://uknowledge.uky.edu/chemistry_facpub/125Test; https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1125&context=chemistry_facpubTest

الإتاحة: https://uknowledge.uky.edu/chemistry_facpub/125Test
https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1125&context=chemistry_facpubTest

المؤلفون: Pitsawong, Warintra, Haynes, Chad A., Koder, Ronald L., Rodgers, David W., Miller, Anne-Frances

المصدر: Chemistry Faculty Publications

مصطلحات موضوعية: Nitroreductase, flavoenzyme, structure, prodrug activation, remediation, Bacterial Proteins, Binding Sites, Enterobacter cloacae, Flavins, NAD, Nitrobenzoates, Nitroreductases, Protein Binding, Substrate Specificity, Biochemistry, Biophysics, and Structural Biology, Chemistry

وصف الملف: application/pdf

العلاقة: Protein structures and data upon which they rest have been deposited to the Protein Data Bank under the accession codes 5J8D (Coordinates and structure factors for NAAD⋅NR) and 5J8G (Coordinates and structure factors for p -NBA⋅NR). Supplemental Information includes seven figures and two tables and can be found with this article online at https://doi.org/10.1016/j.str.2017.05.002Test .; https://uknowledge.uky.edu/chemistry_facpub/152Test; https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1152&context=chemistry_facpubTest

الإتاحة: https://doi.org/10.1016/j.str.2017.05.002Test
https://uknowledge.uky.edu/chemistry_facpub/152Test
https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1152&context=chemistry_facpubTest

المؤلفون: Nivinskas, Henrikas¹, Staškevičiené, Sigita¹, Šarlauskas, Jonas¹, Koder, Ronald L.², Miller, Anne-Frances³, Čénas, Narimantas¹ ncenas@bchi.lt

المصدر: Archives of Biochemistry & Biophysics. Jul2002, Vol. 403 Issue 2, p249. 10p.

مصطلحات موضوعية: *ENTEROBACTER cloacae, *QUINONE