دورية أكاديمية
Pediatric Investigators Collaborative Network on Infections in Canada Study of Respiratory Syncytial Virus-associated Deaths in Pediatric Patients in Canada, 2003-2013.
| العنوان: | Pediatric Investigators Collaborative Network on Infections in Canada Study of Respiratory Syncytial Virus-associated Deaths in Pediatric Patients in Canada, 2003-2013. |
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| المؤلفون: | Tam, J., Papenburg, J., Fanella, S., Asner, S., Barton, M., Bergeron, C., Desai, S., Hui, C., Foo, C., Langley, J.M., Leifso, K., Ma, M.L., Pernica, J., Robinson, J., Singh, R., Tapiero, B., Allen, U. |
| المصدر: | Clinical infectious diseases, vol. 68, no. 1, pp. 113-119 |
| سنة النشر: | 2019 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Adolescent, Bronchiolitis/mortality, Canada/epidemiology, Child, Preschool, Female, Humans, Incidence, Infant, Newborn, Male, Pneumonia, Viral/mortality, Respiratory Syncytial Virus Infections/mortality, Retrospective Studies, Risk Factors, Survival Analysis |
| الوصف: | Respiratory syncytial virus (RSV) is a major cause of pneumonia and bronchiolitis in children. Mortality rates in previously healthy children hospitalized with RSV are <0.5%, but up to 37% in patients with underlying medical conditions. The objective of this study was to characterize factors associated with deaths among children hospitalized with RSV infection in Canadian pediatric centers. A retrospective case series of children aged ≤18 years with RSV-associated deaths at centers affiliated with the Pediatric Investigators Collaborative Network on Infections in Canada from 2003–2013, inclusive, was performed [corrected]. Cases were identified using RSV-specific International Classification of Diseases codes to capture deaths where a diagnosis of RSV infection was present. Eleven centers reported 79 RSV-associated deaths. RSV was regarded as primarily responsible for death in 32 cases (40.5%). Median age at death was 11 months (range, <1 month to 16 years). Thirty-nine patients (49.4%) were male. Fourteen patients (17.7%) had no known risk factors for severe RSV infection. Healthcare-associated RSV infections (HAIs) accounted for 29 deaths (36.7%), with RSV judged to be the primary cause of death in 9 of these cases. RSV-associated deaths were predominantly associated with chronic medical conditions and immunocompromised states among infants; however, 1 in 5 deaths occurred among patients with no known risk factors for severe RSV. Mortality associated with HAI accounted for over a third of cases. These findings highlight patient groups that should be targeted for RSV prevention strategies such as infection control practices, immunoprophylaxis, and future vaccination programs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1058-4838 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29788036; info:eu-repo/semantics/altIdentifier/eissn/1537-6591; https://serval.unil.ch/notice/serval:BIB_38940796536FTest; urn:issn:1058-4838 |
| DOI: | 10.1093/cid/ciy413 |
| الإتاحة: | https://doi.org/10.1093/cid/ciy413Test https://serval.unil.ch/notice/serval:BIB_38940796536FTest |
| رقم الانضمام: | edsbas.85C253DB |
| قاعدة البيانات: | BASE |
| تدمد: | 10584838 |
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| DOI: | 10.1093/cid/ciy413 |