المؤلفون: Chappell E., Turkova A., Goetghebuer T., Jackson C., Chiappini E., Galli L., Gingaras C., Judd A., Spoulou V., Lisi C., Ansone S., Wolfs T., Marczynska M., Ene L., Plotnikova Y., Voronin E., Samarina A., Jourdain G., Ngo-Giang-Huong N., Fortuny C., Navarro M. L., Ramos J. T., Naver L., Crisinel P. -A., Bailey H., Malyuta R., Volokha A., Bamford A., Crichton S., Foster C., Thorne C., Collins I. J., Giaquinto C., Gibb D. M., Critchton S., Duff C., Goodall R., Gomezpena D., Lundin R., Mangiarini L., Milanzi E., Nardone A., Hainaut M., Van der Kelen E., Delforge M., de Martino M., Tovo P. A., Gabiano C., Carloni I., Larovere D., Baldi F., Miniaci A., Pession A., Badolato R., Panto G., Anastasio E., Montagnani C., Venturini E., Bianchi L., Allodi A., Di Biagio A., Grignolo S., Giacomet V., Marchisio P., Banderali G., Tagliabue C., Cellini M., Bruzzese E., Di Costanzo P., Lo Vecchio A., Dona D., Rampon O., Romano A., Dodi I., Esposito S., Zuccaro V., Zanaboni D., Consolini R., Bernardi S., Genovese O., Cristiano L., Mazza A., Garazzino S., Mignone F., Silvestro E., Portelli V., Pajkrt D., Scherpbier H. J., Weijsenfeld A. M., de Boer C. G., Jurriaans S., Back N. K. T., Zaaijer H. L., Berkhout B., Cornelissen M. T. E., Schinkel C. J., Wolthers K. C., Fraaij P. L. A., van Rossum A. M. C., Vermont C. L., van der Knaap L. C., Visser E. G., Boucher C. A. B., Koopmans M. P. G., van Kampen J. J. A., Pas S. D., Henriet S. S. V., van de Flier M., van Aerde K., Strik-Albers R., Rahamat-Langendoen J., Stelma F. F., Scholvinck E. H., de Groot-De Jonge H., Niesters H. G. M., van Leer-Buter C. C., Knoester M., Bont L. J., Geelen S. P. M., Wolfs T. F. W., Nauta N., Schuurman R., Verduyn-Lunel F., Wensing A. M. J., Reiss P., Zaheri S., Bezemer D. O., van Sighem A. I., Smit C., Wit F. W. M. N., Hillebregt M., de Jong A., Woudstra T., Bergsma D., Grivell S., Meijering R., Raethke M., Rutkens T., de Groot L., van den Akker M., Bakker Y., Bezemer M., El Berkaoui A., Geerlinks J., Koops J., Kruijne E., Lodewijk C., Lucas E., van der Meer R., Munjishvili L., Paling F., Peeck B., Ree C., Regtop R., Ruijs Y., van de Sande L., Schoorl M., Schnorr P., Tuijn E., Veenenberg L., van der Vliet S., Wisse A., Witte E. C., Tuk B., Popielska J., Pokorska-Spiewak M., Oldakowska A., Zawadka K., Coupland U., Doroba M., Miloenko M., Labutina S., Soler-Palacin P., Frick M. A., Perez-Hoyos S., Mur A., Lopez N., Mendez M., Mayol L., Vallmanya T., Calavia O., Garcia L., Coll M., Pineda V., Rius N., Rovira N., Duenas J., Noguera-Julian A., Mellado M. J., Escosa L., Hortelano M. G., Sainz T., Gonzalez-Tome M. I., Rojo P., Blazquez D., Prieto L., Guillen S., Saavedra J., Santos M., Munoz M. A., Ruiz B., Fernandez C., Phee M., de Ory S. J., Alvarez S., Roa M. A., Beceiro J., Martinez J., Badillo K., Apilanez M., Pocheville I., Garrote E., Colino E., Sirvent J. G., Garzon M., Roman V., Montesdeoca A., Mateo M., Munoz M. J., Angulo R., Neth O., Falcon L., Terol P., Santos J. L., Moreno D., Lendinez F., Grande A., Romero F. J., Perez C., Lillo M., Losada B., Herranz M., Bustillo M., Guerrero C., Collado P., Couceiro J. A., Perez A., Piqueras A. I., Breton R., Segarra I., Gavilan C., Jareno E., Montesinos E., Dapena M., Alvarez C., Andres A. G., Marugan V., Ochoa C., Alfayate S., Menasalvas A. I., de Miguel E., Soeria-Atmadja S., Belfrage E., Hagas V., Aebi-Popp K., Anagnostopoulos A., Asner S., Battegay M., Baumann M., Bernasconi E., Boni J., Braun D. L., Bucher H. C., Calmy A., Cavassini M., Ciuffi A., Duppenthaler A., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Francini K., Furrer H., Fux C. A., Grawe C., Gunthard H. F., Haerry D., Hasse B., Hirsch H. H., Hoffmann M., Hosli I., Huber M., Kahlert C. R., Kaiser L., Keiser O., Klimkait T., Kottanattu L., Kouyos R. D., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Marzolini C., Metzner K. J., Muller N., Nicca D., Paioni P., Pantaleo G., Perreau M., Polli Ch., Rauch A., Rudin C., Scherrer A. U., Schmid P., Speck R., Stockle M., Tarr P., Thanh Lecompte M., Trkola A., Vernazza P., Wagner N., Wandeler G., Weber R., Wyler C. A., Yerly S., Wannarit P., Techakunakorn P., Hansudewechakul R., Wanchaitanawong V., Theansavettrakul S., Nanta S., Ngampiyaskul C., Phanomcheong S., Hongsiriwon S., Karnchanamayul W., Kwanchaipanich R., Kanjanavanit S., Kamonpakorn N., Nantarukchaikul M., Layangool P., Mekmullica J., Lucksanapisitkul P., Watanayothin S., Lertpienthum N., Warachit B., Hanpinitsak S., Potchalongsin S., Thanasiri P., Krikajornkitti S., Attavinijtrakarn P., Srirojana S., Bunjongpak S., Puangsombat A., Na-Rajsima S., Ananpatharachai P., Akarathum N., Lawtongkum W., Kheunjan P., Suriyaboon T., Saipanya A., Than-In-At K., Jaisieng N., Suaysod R., Chailoet S., Naratee N., Kawilapat S., Kaleeva T., Baryshnikova Y., Soloha S., Bashkatova N., Raus I., Glutshenko O., Ruban Z., Prymak N., Kiseleva G., Lyall H., Butler K., Doerholt K., Doherty C., Harrison I., Kenny J., Klein N., Letting G., McMaster P., Murau F., Nsangi E., Prime K., Riordan A., Shackley F., Shingadia D., Storey S., Tudor-Williams G., Welch S., Cook C., Dobson D., Fairbrother K., Le Prevost M., Van Looy N., Peters H., Francis K., Thrasyvoulou L., Fidler K., Bernatoniene J., Manyika F., Sharpe G., Subramaniam B., Hague R., Price V., Flynn J., Cardoso A., Abou-Rayyah M., Yeadon S., Segal S., Hawkins S., Dowie M., Bandi S., Percival E., Eisenhut M., Duncan K., Anguvaa L., Wren L., Flood T., Pickering A., Murphy C., Daniels J., Lees Y., Thompson F., Williams A., Williams B., Pope S., Libeschutz S., Cliffe L., Southall S., Freeman A., Freeman H., Christie S., Gordon A., Hague D. R., Clarke L., Jones L., Brown L., Greenberg M., Benson C., Ibberson L., Patel S., Hancock J., Sharland M., Lyall E. G. H., Seery P., Kirkhope N., Raghunanan S., Callaghan A., Bridgwood A., Evans J., Blake E., Yannoulias A.

المساهمون: Chappell E., Turkova A., Goetghebuer T., Jackson C., Chiappini E., Galli L., Gingaras C., Judd A., Spoulou V., Lisi C., Ansone S., Wolfs T., Marczynska M., Ene L., Plotnikova Y., Voronin E., Samarina A., Jourdain G., Ngo-Giang-Huong N., Fortuny C., Navarro M.L., Ramos J.T., Naver L., Crisinel P.-A., Bailey H., Malyuta R., Volokha A., Bamford A., Crichton S., Foster C., Thorne C., Collins I.J., Giaquinto C., Gibb D.M., Critchton S., Duff C., Goodall R., Gomezpena D., Lundin R., Mangiarini L., Milanzi E., Nardone A., Hainaut M., Van der Kelen E., Delforge M., de Martino M., Tovo P.A., Gabiano C., Carloni I., Larovere D., Baldi F., Miniaci A., Pession A., Badolato R., Panto G., Anastasio E., Montagnani C., Venturini E., Bianchi L., Allodi A., Di Biagio A., Grignolo S., Giacomet V., Marchisio P., Banderali G., Tagliabue C., Cellini M., Bruzzese E., Di Costanzo P., Lo Vecchio A., Dona D., Rampon O., Romano A., Dodi I., Esposito S., Zuccaro V., Zanaboni D., Consolini R., Bernardi S., Genovese O., Cristiano L., Mazza A., Garazzino S., Mignone F., Silvestro E., Portelli V., Pajkrt D., Scherpbier H.J., Weijsenfeld A.M., de Boer C.G., Jurriaans S., Back N.K.T., Zaaijer H.L., Berkhout B., Cornelissen M.T.E., Schinkel C.J., Wolthers K.C., Fraaij P.L.A., van Rossum A.M.C., Vermont C.L.

مصطلحات موضوعية: Adolescent, Adult, Aged, Child, Europe, Eastern, Human, Infant, Newborn, Male, Thailand, Acquired Immunodeficiency Syndrome, HIV Infection, Neoplasms

الوصف: Investigate trends over time and predictors of malignancies among children and young people with HIV.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34049355; volume:35; issue:12; firstpage:1973; lastpage:1985; numberofpages:13; journal:AIDS; http://hdl.handle.net/2318/1870185Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85115442760

الإتاحة: https://doi.org/10.1097/QAD.0000000000002965Test
http://hdl.handle.net/2318/1870185Test

المؤلفون: Cordey, S., Schibler, M., L'Huillier, A.G., Wagner, N., Gonçalves, A.R., Ambrosioni, J., Asner, S., Turin, L., Posfay-Barbe, K.M., Kaiser, L.

المصدر: Journal of clinical virology, vol. 89, pp. 22-29

مصطلحات موضوعية: Adolescent, Adult, Age Factors, Aged, 80 and over, Bodily Secretions/virology, Body Fluids/virology, Child, Preschool, Enterovirus Infections/virology, Feces/virology, Female, Humans, Infant, Newborn, Male, Meningitis, Aseptic/virology, Middle Aged, Prospective Studies, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Switzerland, Virus Shedding, Young Adult, CNS infection, Enterovirus, Epidemiology, Viral shedding

الوصف: Several enterovirus (EV) genotypes can result in aseptic meningitis, but their routes of access to the central nervous system remain to be elucidated and may differ between the pediatric and adult populations. To assess the pattern of viral shedding in pediatric and adult subjects with acute EV meningitis and to generate EV surveillance data for Switzerland. All pediatric and adult subjects admitted to the University Hospitals of Geneva with a diagnosis of EV meningitis between 2013 and 2015 were enrolled. A quantitative EV real-time reverse transcriptase (rRT)-PCR was performed on the cerebrospinal fluid (CSF), blood, stool, urine and respiratory specimens to assess viral shedding and provide a comparative analysis of pediatric and adult populations. EV genotyping was systematically performed. EV positivity rates differed significantly between pediatric and adult subjects; 62.5% of pediatric cases (no adult case) were EV-positive in stool and blood for subjects for whom these samples were all collected. Similarly, the EV viral load in blood was significantly higher in pediatric subjects. Blood C-reactive protein levels were lower and the number of leucocytes/mm3 in the CSF were higher in non-viremic than in viremic pediatric subjects, respectively. A greater diversity of EV genotypes was observed in pediatric cases, with a predominance of echovirus 30 in children ≥3 years old and adults. In contrast to adults, EV-disseminated infections are predominant in pediatric subjects and show different patterns of EV viral shedding. This observation may be useful for clinicians and contribute to modify current practices of patient care.

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28214758; info:eu-repo/semantics/altIdentifier/eissn/1873-5967; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_62964BB36C1A6; https://serval.unil.ch/notice/serval:BIB_62964BB36C1ATest; urn:issn:1386-6532; https://serval.unil.ch/resource/serval:BIB_62964BB36C1A.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_62964BB36C1A6Test

الإتاحة: https://doi.org/10.1016/j.jcv.2017.01.008Test
https://serval.unil.ch/notice/serval:BIB_62964BB36C1ATest
https://serval.unil.ch/resource/serval:BIB_62964BB36C1A.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_62964BB36C1A6Test

المؤلفون: Rio, L., Ramelet, A.S., Ballabeni, P., Stadelmann, C., Asner, S., Giannoni, E.

المصدر: Pediatric research, vol. 92, no. 4, pp. 1070-1074

مصطلحات موضوعية: Infant, Newborn, Humans, Neonatal Sepsis/diagnosis, Heart Rate/physiology, Retrospective Studies, Case-Control Studies, Gestational Age

الوصف: Monitoring of heart rate characteristics (HRC) index may improve outcomes of late-onset neonatal sepsis (LOS) through early detection. We aimed at describing the association between LOS and elevated HRC index. This single-center retrospective case-control study included neonates who presented with blood culture-proven hospital-acquired LOS. Controls were matched to cases (ratio 1:2) based on gestational age, postnatal age, and birthweight. We compared the highest HRC indexes in the 48 h preceding blood culture sampling in LOS cases to the highest HRC indexes at the same postnatal days in controls. In 59 LOS cases and 123 controls, an HRC index > 2 was associated with LOS (OR 7.1, 95% CI 2.6-19.0). Sensitivity and specificity of an HRC index > 2 to predict LOS were 53% (32/59) and 79% (98/123). Sensitivity increased from 25% in infants born > 32 weeks to 76% in infants born < 28 weeks. Specificity decreased from 97% in infants > 32 weeks to 63% in those born < 28 weeks. An increase of HRC index > 2 has a significant association with the diagnosis of LOS, supporting the use of HRC monitoring to assist early detection of LOS. Clinicians using HRC monitoring should be aware of its diagnostic accuracy and limitations in different gestational age groups. There is a paucity of data regarding the predictive value of heart rate characteristics (HRC) monitoring for early diagnosis of late-onset neonatal sepsis (LOS) in daily clinical practice. Monitoring of heart rate characteristics provides valuable information to assist the early diagnosis of LOS across all gestational age groups. However, the strong influence of gestational age on positive and negative predictive values adds complexity to the interpretation of HRC indexes.

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34916625; info:eu-repo/semantics/altIdentifier/eissn/1530-0447; https://serval.unil.ch/notice/serval:BIB_5F68AF69F2BETest; urn:issn:0031-3998; https://serval.unil.ch/resource/serval:BIB_5F68AF69F2BE.P001/REF.pdfTest

الإتاحة: https://doi.org/10.1038/s41390-021-01913-9Test
https://serval.unil.ch/notice/serval:BIB_5F68AF69F2BETest
https://serval.unil.ch/resource/serval:BIB_5F68AF69F2BE.P001/REF.pdfTest

المؤلفون: Chappell, E., Turkova, A., Goetghebuer, T., Jackson, C., Chiappini, E., Galli, L., Gingaras, C., Judd, A., Spoulou, V., Lisi, C., Ansone, S., Wolfs, T., Marczynska, M., Ene, L., Plotnikova, Y., Voronin, E., Samarina, A., Jourdain, G., Ngo-Giang-Huong, N., Fortuny, C., Navarro, M. L., Ramos, J. T., Naver, L., Crisinel, P. -A., Bailey, H., Malyuta, R., Volokha, A., Bamford, A., Crichton, S., Foster, C., Thorne, C., Collins, I. J., Giaquinto, C., Gibb, D. M., Critchton, S., Duff, C., Goodall, R., Gomezpena, D., Lundin, R., Mangiarini, L., Milanzi, E., Nardone, A., Hainaut, M., Van der Kelen, E., Delforge, M., de Martino, M., Tovo, P. A., Gabiano, C., Carloni, I., Larovere, D., Baldi, F., Miniaci, A., Pession, A., Badolato, R., Panto, G., Anastasio, E., Montagnani, C., Venturini, E., Bianchi, L., Allodi, A., Di Biagio, A., Grignolo, S., Giacomet, V., Marchisio, P., Banderali, G., Tagliabue, C., Cellini, M., Bruzzese, E., Di Costanzo, P., Lo Vecchio, A., Dona', D., Rampon, O., Romano, A., Dodi, I., Esposito, S., Zuccaro, V., Zanaboni, D., Consolini, R., Bernardi, S., Genovese, O., Cristiano, L., Mazza, A., Garazzino, S., Mignone, F., Silvestro, E., Portelli, V., Pajkrt, D., Scherpbier, H. J., Weijsenfeld, A. M., de Boer, C. G., Jurriaans, S., Back, N. K. T., Zaaijer, H. L., Berkhout, B., Cornelissen, M. T. E., Schinkel, C. J., Wolthers, K. C., Fraaij, P. L. A., van Rossum, A. M. C., Vermont, C. L., van der Knaap, L. C., Visser, E. G., Boucher, C. A. B., Koopmans, M. P. G., van Kampen, J. J. A., Pas, S. D., Henriet, S. S. V., van de Flier, M., van Aerde, K., Strik-Albers, R., Rahamat-Langendoen, J., Stelma, F. F., Scholvinck, E. H., de Groot-De Jonge, H., Niesters, H. G. M., van Leer-Buter, C. C., Knoester, M., Bont, L. J., Geelen, S. P. M., Wolfs, T. F. W., Nauta, N., Schuurman, R., Verduyn-Lunel, F., Wensing, A. M. J., Reiss, P., Zaheri, S., Bezemer, D. O., van Sighem, A. I., Smit, C., Wit, F. W. M. N., Hillebregt, M., de Jong, A., Woudstra, T., Bergsma, D., Grivell, S., Meijering, R., Raethke, M., Rutkens, T., de Groot, L., van den Akker, M., Bakker, Y., Bezemer, M., El Berkaoui, A., Geerlinks, J., Koops, J., Kruijne, E., Lodewijk, C., Lucas, E., van der Meer, R., Munjishvili, L., Paling, F., Peeck, B., Ree, C., Regtop, R., Ruijs, Y., van de Sande, L., Schoorl, M., Schnorr, P., Tuijn, E., Veenenberg, L., van der Vliet, S., Wisse, A., Witte, E. C., Tuk, B., Popielska, J., Pokorska-Spiewak, M., Oldakowska, A., Zawadka, K., Coupland, U., Doroba, M., Miloenko, M., Labutina, S., Soler-Palacin, P., Frick, M. A., Perez-Hoyos, S., Mur, A., Lopez, N., Mendez, M., Mayol, L., Vallmanya, T., Calavia, O., Garcia, L., Coll, M., Pineda, V., Rius, N., Rovira, N., Duenas, J., Noguera-Julian, A., Mellado, M. J., Escosa, L., Hortelano, M. G., Sainz, T., Gonzalez-Tome, M. I., Rojo, P., Blazquez, D., Prieto, L., Guillen, S., Saavedra, J., Santos, M., Munoz, M. A., Ruiz, B., Fernandez, C., Phee, M., de Ory, S. J., Alvarez, S., Roa, M. A., Beceiro, J., Martinez, J., Badillo, K., Apilanez, M., Pocheville, I., Garrote, E., Colino, E., Sirvent, J. G., Garzon, M., Roman, V., Montesdeoca, A., Mateo, M., Munoz, M. J., Angulo, R., Neth, O., Falcon, L., Terol, P., Santos, J. L., Moreno, D., Lendinez, F., Grande, A., Romero, F. J., Perez, C., Lillo, M., Losada, B., Herranz, M., Bustillo, M., Guerrero, C., Collado, P., Couceiro, J. A., Perez, A., Piqueras, A. I., Breton, R., Segarra, I., Gavilan, C., Jareno, E., Montesinos, E., Dapena, M., Alvarez, C., Andres, A. G., Marugan, V., Ochoa, C., Alfayate, S., Menasalvas, A. I., de Miguel, E., Soeria-Atmadja, S., Belfrage, E., Hagas, V., Aebi-Popp, K., Anagnostopoulos, A., Asner, S., Battegay, M., Baumann, M., Bernasconi, E., Boni, J., Braun, D. L., Bucher, H. C., Calmy, A., Cavassini, M., Ciuffi, A., Duppenthaler, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Francini, K., Furrer, H., Fux, C. A., Grawe, C., Gunthard, H. F., Haerry, D., Hasse, B., Hirsch, H. H., Hoffmann, M., Hosli, I., Huber, M., Kahlert, C. R., Kaiser, L., Keiser, O., Klimkait, T., Kottanattu, L., Kouyos, R. D., Kovari, H., Ledergerber, B., Martinetti, G., Martinez de Tejada, B., Marzolini, C., Metzner, K. J., Muller, N., Nicca, D., Paioni, P., Pantaleo, G., Perreau, M., Polli, Ch., Rauch, A., Rudin, C., Scherrer, A. U., Schmid, P., Speck, R., Stockle, M., Tarr, P., Thanh Lecompte, M., Trkola, A., Vernazza, P., Wagner, N., Wandeler, G., Weber, R., Wyler, C. A., Yerly, S., Wannarit, P., Techakunakorn, P., Hansudewechakul, R., Wanchaitanawong, V., Theansavettrakul, S., Nanta, S., Ngampiyaskul, C., Phanomcheong, S., Hongsiriwon, S., Karnchanamayul, W., Kwanchaipanich, R., Kanjanavanit, S., Kamonpakorn, N., Nantarukchaikul, M., Layangool, P., Mekmullica, J., Lucksanapisitkul, P., Watanayothin, S., Lertpienthum, N., Warachit, B., Hanpinitsak, S., Potchalongsin, S., Thanasiri, P., Krikajornkitti, S., Attavinijtrakarn, P., Srirojana, S., Bunjongpak, S., Puangsombat, A., Na-Rajsima, S., Ananpatharachai, P., Akarathum, N., Lawtongkum, W., Kheunjan, P., Suriyaboon, T., Saipanya, A., Than-In-At, K., Jaisieng, N., Suaysod, R., Chailoet, S., Naratee, N., Kawilapat, S., Kaleeva, T., Baryshnikova, Y., Soloha, S., Bashkatova, N., Raus, I., Glutshenko, O., Ruban, Z., Prymak, N., Kiseleva, G., Lyall, H., Butler, K., Doerholt, K., Doherty, C., Harrison, I., Kenny, J., Klein, N., Letting, G., Mcmaster, P., Murau, F., Nsangi, E., Prime, K., Riordan, A., Shackley, F., Shingadia, D., Storey, S., Tudor-Williams, G., Welch, S., Cook, C., Dobson, D., Fairbrother, K., Le Prevost, M., Van Looy, N., Peters, H., Francis, K., Thrasyvoulou, L., Fidler, K., Bernatoniene, J., Manyika, F., Sharpe, G., Subramaniam, B., Hague, R., Price, V., Flynn, J., Cardoso, A., Abou-Rayyah, M., Yeadon, S., Segal, S., Hawkins, S., Dowie, M., Bandi, S., Percival, E., Eisenhut, M., Duncan, K., Anguvaa, L., Wren, L., Flood, T., Pickering, A., Murphy, C., Daniels, J., Lees, Y., Thompson, F., Williams, A., Williams, B., Pope, S., Libeschutz, S., Cliffe, L., Southall, S., Freeman, A., Freeman, H., Christie, S., Gordon, A., Hague, D. R., Clarke, L., Jones, L., Brown, L., Greenberg, M., Benson, C., Ibberson, L., Patel, S., Hancock, J., Sharland, M., Lyall, E. G. H., Seery, P., Kirkhope, N., Raghunanan, S., Callaghan, A., Bridgwood, A., Evans, J., Blake, E., Yannoulias, A.

المساهمون: Chappell, E., Turkova, A., Goetghebuer, T., Jackson, C., Chiappini, E., Galli, L., Gingaras, C., Judd, A., Spoulou, V., Lisi, C., Ansone, S., Wolfs, T., Marczynska, M., Ene, L., Plotnikova, Y., Voronin, E., Samarina, A., Jourdain, G., Ngo-Giang-Huong, N., Fortuny, C., Navarro, M. L., Ramos, J. T., Naver, L., Crisinel, P. -A., Bailey, H., Malyuta, R., Volokha, A., Bamford, A., Crichton, S., Foster, C., Thorne, C., Collins, I. J., Giaquinto, C., Gibb, D. M., Critchton, S., Duff, C., Goodall, R., Gomezpena, D., Lundin, R., Mangiarini, L., Milanzi, E., Nardone, A., Hainaut, M., Van der Kelen, E., Delforge, M., de Martino, M., Tovo, P. A., Gabiano, C., Carloni, I., Larovere, D., Baldi, F., Miniaci, A., Pession, A., Badolato, R., Panto, G., Anastasio, E., Montagnani, C., Venturini, E., Bianchi, L., Allodi, A., Di Biagio, A., Grignolo, S., Giacomet, V., Marchisio, P., Banderali, G., Tagliabue, C., Cellini, M., Bruzzese, E., Di Costanzo, P., Lo Vecchio, A., Dona, D., Rampon, O., Romano, A., Dodi, I., Esposito, S., Zuccaro, V., Zanaboni, D., Consolini, R., Bernardi, S., Genovese, O., Cristiano, L., Mazza, A., Garazzino, S., Mignone, F., Silvestro, E., Portelli, V., Pajkrt, D., Scherpbier, H. J., Weijsenfeld, A. M., de Boer, C. G., Jurriaans, S., Back, N. K. T., Zaaijer, H. L., Berkhout, B., Cornelissen, M. T. E., Schinkel, C. J., Wolthers, K. C., Fraaij, P. L. A., van Rossum, A. M. C., Vermont, C. L., van der Knaap, L. C., Visser, E. G., Boucher, C. A. B., Koopmans, M. P. G., van Kampen, J. J. A., Pas, S. D., Henriet, S. S. V., van de Flier, M., van Aerde, K., Strik-Albers, R., Rahamat-Langendoen, J., Stelma, F. F., Scholvinck, E. H., de Groot-De Jonge, H., Niesters, H. G. M., van Leer-Buter, C. C., Knoester, M., Bont, L. J., Geelen, S. P. M., Wolfs, T. F. W., Nauta, N., Schuurman, R., Verduyn-Lunel, F., Wensing, A. M. J., Reiss, P., Zaheri, S., Bezemer, D. O., van Sighem, A. I., Smit, C., Wit, F. W. M. N., Hillebregt, M., de Jong, A., Woudstra, T., Bergsma, D., Grivell, S., Meijering, R., Raethke, M., Rutkens, T., de Groot, L., van den Akker, M., Bakker, Y., Bezemer, M., El Berkaoui, A., Geerlinks, J., Koops, J., Kruijne, E., Lodewijk, C., Lucas, E., van der Meer, R., Munjishvili, L., Paling, F., Peeck, B., Ree, C., Regtop, R., Ruijs, Y., van de Sande, L., Schoorl, M., Schnorr, P., Tuijn, E., Veenenberg, L., van der Vliet, S., Wisse, A., Witte, E. C., Tuk, B., Popielska, J., Pokorska-Spiewak, M., Oldakowska, A., Zawadka, K., Coupland, U., Doroba, M., Miloenko, M., Labutina, S., Soler-Palacin, P., Frick, M. A., Perez-Hoyos, S., Mur, A., Lopez, N., Mendez, M., Mayol, L., Vallmanya, T., Calavia, O., Garcia, L., Coll, M., Pineda, V., Rius, N., Rovira, N., Duenas, J., Noguera-Julian, A., Mellado, M. J., Escosa, L., Hortelano, M. G., Sainz, T., Gonzalez-Tome, M. I., Rojo, P., Blazquez, D., Prieto, L., Guillen, S., Saavedra, J., Santos, M., Munoz, M. A., Ruiz, B., Fernandez, C., Phee, M., de Ory, S. J., Alvarez, S., Roa, M. A., Beceiro, J., Martinez, J., Badillo, K., Apilanez, M., Pocheville, I., Garrote, E., Colino, E., Sirvent, J. G., Garzon, M., Roman, V., Montesdeoca, A., Mateo, M., Munoz, M. J., Angulo, R., Neth, O., Falcon, L., Terol, P., Santos, J. L., Moreno, D., Lendinez, F., Grande, A., Romero, F. J., Perez, C., Lillo, M., Losada, B., Herranz, M., Bustillo, M., Guerrero, C., Collado, P., Couceiro, J. A., Perez, A., Piqueras, A. I., Breton, R., Segarra, I., Gavilan, C., Jareno, E., Montesinos, E., Dapena, M., Alvarez, C., Andres, A. G., Marugan, V., Ochoa, C., Alfayate, S., Menasalvas, A. I., de Miguel, E., Soeria-Atmadja, S., Belfrage, E., Hagas, V., Aebi-Popp, K., Anagnostopoulos, A., Asner, S., Battegay, M., Baumann, M., Bernasconi, E., Boni, J., Braun, D. L., Bucher, H. C., Calmy, A., Cavassini, M., Ciuffi, A., Duppenthaler, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Francini, K., Furrer, H., Fux, C. A., Grawe, C., Gunthard, H. F., Haerry, D., Hasse, B., Hirsch, H. H., Hoffmann, M., Hosli, I., Huber, M., Kahlert, C. R., Kaiser, L., Keiser, O., Klimkait, T., Kottanattu, L., Kouyos, R. D., Kovari, H., Ledergerber, B., Martinetti, G., Martinez de Tejada, B., Marzolini, C., Metzner, K. J., Muller, N., Nicca, D., Paioni, P., Pantaleo, G., Perreau, M., Polli, Ch., Rauch, A., Rudin, C., Scherrer, A. U., Schmid, P., Speck, R., Stockle, M., Tarr, P., Thanh Lecompte, M., Trkola, A., Vernazza, P., Wagner, N., Wandeler, G., Weber, R., Wyler, C. A., Yerly, S., Wannarit, P., Techakunakorn, P., Hansudewechakul, R., Wanchaitanawong, V., Theansavettrakul, S., Nanta, S., Ngampiyaskul, C., Phanomcheong, S., Hongsiriwon, S., Karnchanamayul, W., Kwanchaipanich, R., Kanjanavanit, S., Kamonpakorn, N., Nantarukchaikul, M., Layangool, P., Mekmullica, J., Lucksanapisitkul, P., Watanayothin, S., Lertpienthum, N., Warachit, B., Hanpinitsak, S., Potchalongsin, S., Thanasiri, P., Krikajornkitti, S., Attavinijtrakarn, P., Srirojana, S., Bunjongpak, S., Puangsombat, A., Na-Rajsima, S., Ananpatharachai, P., Akarathum, N., Lawtongkum, W., Kheunjan, P., Suriyaboon, T., Saipanya, A., Than-In-At, K., Jaisieng, N., Suaysod, R., Chailoet, S., Naratee, N., Kawilapat, S., Kaleeva, T., Baryshnikova, Y., Soloha, S., Bashkatova, N., Raus, I., Glutshenko, O., Ruban, Z., Prymak, N., Kiseleva, G., Lyall, H., Butler, K., Doerholt, K., Doherty, C., Harrison, I., Kenny, J., Klein, N., Letting, G., Mcmaster, P., Murau, F., Nsangi, E., Prime, K., Riordan, A., Shackley, F., Shingadia, D., Storey, S., Tudor-Williams, G., Welch, S., Cook, C., Dobson, D., Fairbrother, K., Le Prevost, M., Van Looy, N., Peters, H., Francis, K., Thrasyvoulou, L., Fidler, K., Bernatoniene, J., Manyika, F., Sharpe, G., Subramaniam, B., Hague, R., Price, V., Flynn, J., Cardoso, A., Abou-Rayyah, M., Yeadon, S., Segal, S., Hawkins, S., Dowie, M., Bandi, S., Percival, E., Eisenhut, M., Duncan, K., Anguvaa, L., Wren, L., Flood, T., Pickering, A., Murphy, C., Daniels, J., Lees, Y., Thompson, F., Williams, A., Williams, B., Pope, S., Libeschutz, S., Cliffe, L., Southall, S., Freeman, A., Freeman, H., Christie, S., Gordon, A., Hague, D. R., Clarke, L., Jones, L., Brown, L., Greenberg, M., Benson, C., Ibberson, L., Patel, S., Hancock, J., Sharland, M., Lyall, E. G. H., Seery, P., Kirkhope, N., Raghunanan, S., Callaghan, A., Bridgwood, A., Evans, J., Blake, E., Yannoulias, A.

مصطلحات موضوعية: Adult, Male, Acquired Immunodeficiency Syndrome, Adolescent, Infant, HIV, HIV Infections, Eastern, Adolescents, Newborn, Thailand, Europe, malignancie, Neoplasms, malignancies, Humans, Children, Aged, Child, Europe, Eastern, Infant, Newborn

الوصف: Objectives: Investigate trends over time and predictors of malignancies among children and young people with HIV. Design: Pooled data from 17 cohorts in 15 countries across Europe and Thailand. Methods: Individuals diagnosed with HIV and presenting to paediatric care less than 18 years of age were included. Time at risk began at birth for children with documented vertically acquired HIV, and from first HIV-care visit for others. Children were followed until death, loss-to-follow-up, or last visit in paediatric or adult care (where data after transfer to adult care were available). Rates of reported malignancies were calculated overall and for AIDS-defining malignancies (ADM) and non-AIDS-defining malignancies (NADM) separately. Risk factors for any malignancy were explored using Poisson regression, and for mortality following a malignancy diagnosis using Cox regression. Results: Among 9632 individuals included, 140 (1.5%) were ever diagnosed with a malignancy, of which 112 (80%) were ADM. Overall, the rate of any malignancy was 1.18 per 1000 person-years; the rate of ADM decreased over time whereas the rate of NADM increased. Male sex, being from a European cohort, vertically acquired HIV, current severe immunosuppression, current viral load greater than 400 copies/ml, older age, and, for those not on treatment, earlier calendar year, were risk factors for a malignancy diagnosis. Fifty-eight (41%) individuals with a malignancy died, a median 2.4 months (IQR 0.6-8.8) after malignancy diagnosis. Conclusion: The rate of ADM has declined since widespread availability of combination ART, although of NADM, there was a small increase. Mortality following a malignancy was high, warranting further investigation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9b55f62479ac408444c4ccdfc5b4bc51Test
https://hdl.handle.net/11588/913028Test

المؤلفون: Tam, J., Papenburg, J., Fanella, S., Asner, S., Barton, M., Bergeron, C., Desai, S., Hui, C., Foo, C., Langley, J.M., Leifso, K., Ma, M.L., Pernica, J., Robinson, J., Singh, R., Tapiero, B., Allen, U.

المصدر: Clinical infectious diseases, vol. 68, no. 1, pp. 113-119

مصطلحات موضوعية: Adolescent, Bronchiolitis/mortality, Canada/epidemiology, Child, Preschool, Female, Humans, Incidence, Infant, Newborn, Male, Pneumonia, Viral/mortality, Respiratory Syncytial Virus Infections/mortality, Retrospective Studies, Risk Factors, Survival Analysis

الوصف: Respiratory syncytial virus (RSV) is a major cause of pneumonia and bronchiolitis in children. Mortality rates in previously healthy children hospitalized with RSV are <0.5%, but up to 37% in patients with underlying medical conditions. The objective of this study was to characterize factors associated with deaths among children hospitalized with RSV infection in Canadian pediatric centers. A retrospective case series of children aged ≤18 years with RSV-associated deaths at centers affiliated with the Pediatric Investigators Collaborative Network on Infections in Canada from 2003–2013, inclusive, was performed [corrected]. Cases were identified using RSV-specific International Classification of Diseases codes to capture deaths where a diagnosis of RSV infection was present. Eleven centers reported 79 RSV-associated deaths. RSV was regarded as primarily responsible for death in 32 cases (40.5%). Median age at death was 11 months (range, <1 month to 16 years). Thirty-nine patients (49.4%) were male. Fourteen patients (17.7%) had no known risk factors for severe RSV infection. Healthcare-associated RSV infections (HAIs) accounted for 29 deaths (36.7%), with RSV judged to be the primary cause of death in 9 of these cases. RSV-associated deaths were predominantly associated with chronic medical conditions and immunocompromised states among infants; however, 1 in 5 deaths occurred among patients with no known risk factors for severe RSV. Mortality associated with HAI accounted for over a third of cases. These findings highlight patient groups that should be targeted for RSV prevention strategies such as infection control practices, immunoprophylaxis, and future vaccination programs.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29788036; info:eu-repo/semantics/altIdentifier/eissn/1537-6591; https://serval.unil.ch/notice/serval:BIB_38940796536FTest; urn:issn:1058-4838

الإتاحة: https://doi.org/10.1093/cid/ciy413Test
https://serval.unil.ch/notice/serval:BIB_38940796536FTest

المؤلفون: Science, M., Akseer, N., Asner, S., Allen, U.

المصدر: Pediatric transplantation, vol. 23, no. 2, pp. e13336

مصطلحات موضوعية: Adolescent, Child, Preschool, Clinical Decision-Making/methods, Female, Humans, Immunocompromised Host, Infant, Newborn, Linear Models, Logistic Models, Male, Postoperative Complications/diagnosis, Postoperative Complications/immunology, Postoperative Complications/prevention & control, Respiratory Syncytial Virus Infections/diagnosis, Respiratory Syncytial Virus Infections/immunology, Respiratory Syncytial Virus Infections/prevention & control, Retrospective Studies, Risk Assessment, Risk Factors, Transplant Recipients, RSV, immunocompromised, pediatrics

الوصف: Respiratory syncytial virus (RSV) infection is associated with increased morbidity and mortality in immunocompromised patients. Our goal was to develop a framework for risk stratifying immunocompromised patients, including transplant patients, for RSV prophylaxis. Risk factors for severe RSV disease in immunocompromised patients were identified in the literature and by an expert panel via survey. Experts assigned a probability of developing severe disease (0 to 100 scale) to the risk factors for each immunocompromised population. The results were validated using a clinical dataset. Linear mixed models adjusted for within-expert clustering of ranks were used to estimate average scores, and differences were tested using paired t tests. Logistic regression was utilized to identify important determinants of severe RSV disease. The survey was emailed to twenty-seven experts and thirteen responded (48%). Across all transplant groups, age <2 years (mean 77.1, 95% CI 71.7, 82.5) and day care attendance (mean 72.8, 95% CI 67.3, 78.3) were assigned the highest risk of severe disease. The highest risk groups were lung transplant recipients (mean 73.2, 95% CI 67.6, 78.8), combined lung and heart transplant recipients (mean 75.2, 95% CI 69.6, 80.7), allogeneic stem cell transplant (mean 76.0, 95% CI 70.4, 81.6), and severe combined immunodeficiency (mean 74.7, 95% CI 69.1, 80.3). The results provide a logical validity to current practice and provide guidance for prioritizing patients to receive prophylactic agents to prevent severe RSV disease. The results will facilitate the development of a risk stratification tool for RSV prophylaxis for immunocompromised patients.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30604582; info:eu-repo/semantics/altIdentifier/eissn/1399-3046; https://serval.unil.ch/notice/serval:BIB_B1346E21C8D9Test; urn:issn:1397-3142

الإتاحة: https://doi.org/10.1111/petr.13336Test
https://serval.unil.ch/notice/serval:BIB_B1346E21C8D9Test