دورية أكاديمية
Maximal concentration of intravenous busulfan as a determinant of veno-occlusive disease: a pharmacokinetic-pharmacodynamic analysis in 293 hematopoietic stem cell transplanted children
| العنوان: | Maximal concentration of intravenous busulfan as a determinant of veno-occlusive disease: a pharmacokinetic-pharmacodynamic analysis in 293 hematopoietic stem cell transplanted children |
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| المؤلفون: | Philippe, Michaël, Neely, Michael, Rushing, Teresa, Bertrand, Yves, Bleyzac, Nathalie, Goutelle, Sylvain |
| المساهمون: | Centre Léon Bérard Lyon, Laboratory of Applied Pharmacokinetics, University of California Los Angeles (UCLA), University of California (UC)-University of California (UC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Evaluation et modélisation des effets thérapeutiques LBBE, Département biostatistiques et modélisation pour la santé et l'environnement LBBE, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 - Institut des Sciences Pharmaceutiques et Biologiques (UCBL ISPB), Université de Lyon-Université de Lyon, Hospices Civils de Lyon (HCL) |
| المصدر: | ISSN: 0268-3369 ; Bone Marrow Transplantation ; https://hal.science/hal-04627174Test ; Bone Marrow Transplantation, 2018, 54 (3), pp.448-457. ⟨10.1038/s41409-018-0281-7⟩. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2018 |
| المجموعة: | Hospices Civils de Lyon (HCL): HAL |
| مصطلحات موضوعية: | MESH: Administration, Intravenous, MESH: Adolescent, MESH: Immunosuppressive Agents, MESH: Infant, Newborn, MESH: Male, MESH: Retrospective Studies, MESH: Transplantation Conditioning, MESH: Young Adult, MESH: Adult, MESH: Busulfan, MESH: Child, Preschool, MESH: Female, MESH: Hematopoietic Stem Cell Transplantation, MESH: Hepatic Veno-Occlusive Disease, MESH: Humans, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology |
| الوصف: | International audience ; Veno-occlusive disease (VOD) is a severe adverse reaction to busulfan-containing regimens used in the preparation of children for hematopoietic stem cell transplantation (HSCT). We conducted a retrospective analysis of data to examine determinants of VOD in children who received IV busulfan for HSCT conditioning. Busulfan PK parameters as well as various indices (maximal concentration-Cmax, area under the concentration-time curve-AUC) were estimated using a validated Bayesian approach. The influence of available PK, demographic, and clinical variables on the incidence of VOD was evaluated by using logistic regression and classification and regression tree (CART) analyses. Among the 293 patients included, the mean age was 6.5 years and the mean actual body weight was 26.3 kg. The incidence of VOD was 25.6%. Busulfan Cmax as well as weight <9 kg or age <3 years were identified as independent predictors of VOD in logistic regression analysis. CART analysis identified busulfan Cmax over the entire regimen as the strongest predictor of VOD. This study suggests that busulfan-associated VOD is in part a concentration-dependent reaction. In addition, the youngest children showed the highest risk of VOD. These findings may have important implications for busulfan dosing and therapeutic drug monitoring practice in HSCT children. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30108322; hal-04627174; https://hal.science/hal-04627174Test; PUBMED: 30108322 |
| DOI: | 10.1038/s41409-018-0281-7 |
| الإتاحة: | https://doi.org/10.1038/s41409-018-0281-7Test https://hal.science/hal-04627174Test |
| رقم الانضمام: | edsbas.A633A2F3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41409-018-0281-7 |
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