التفاصيل البيبلوغرافية
| العنوان: |
Evidence for Functional Networks within the Human Brain's White Matter. |
| المؤلفون: |
Peer, Michael, Nitzan, Mor, Bick, Atira S., Levin, Netta, Arzy, Shahar |
| المصدر: |
Journal of Neuroscience; 7/5/2017, Vol. 37 Issue 27, p6394-6407, 14p |
| مصطلحات موضوعية: |
CEREBRAL cortex, WHITE matter (Nerve tissue), BRAIN, NEUROSCIENCES, NEUROPSYCHIATRY |
| مستخلص: |
Investigation of the functional macro-scale organization of the human cortex is fundamental in modern neuroscience. Although numerous studies have identified networks of interacting functional modules in the gray-matter, limited research was directed to the functional organization of the white-matter. Recent studies have demonstrated that the white-matter exhibits blood oxygen level-dependent signal fluctuations similar to those of the gray-matter. Here we used these signal fluctuations to investigate whether the white-matter is organized as functional networks by applying a clustering analysis on resting-state functional MRI (RSfMRI) data from white-matter voxels, in 176 subjects (of both sexes). This analysis indicated the existence of 12 symmetrical white-matter functional networks, corresponding to combinations of white-matter tracts identified by diffusion tensor imaging. Six of the networks included interhemispheric commissural bridges traversing the corpus callosum. Signals in white-matter networks correlated with signals from functional gray-matter networks, providing missing knowledge on how these distributed networks communicate across large distances. These findings were replicated in an independent subject group and were corroborated by seed-based analysis in small groups and individual subjects. The identified white-matter functional atlases and analysis codes are available at http://mind.huji.ac.il/white-matter.aspxTest. Our results demonstrate that the white-matter manifests an intrinsic functional organization as interacting networks of functional modules, similarly to the gray-matter, which can be investigated using RSfMRI. The discovery of functional networks within the white-matter may open new avenues of research in cognitive neuroscience and clinical neuropsychiatry. [ABSTRACT FROM AUTHOR] |
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