المؤلفون: Daphne ter Huurne, Inez Ramakers, Nina Possemis, Leonie Banning, Angelique Gruters, Stephanie Van Asbroeck, Alexandra König, Nicklas Linz, Johannes Tröger, Kai Langel, Frans Verhey, Marjolein de Vugt

المصدر: Archives of Clinical Neuropsychology.

مصطلحات موضوعية: MILD COGNITIVE IMPAIRMENT, NORMATIVE DATA, EDUCATION, General Medicine, PERFORMANCE, ALZHEIMERS-DISEASE, Psychiatry and Mental health, Clinical Psychology, VERBAL FLUENCY, Neuropsychology and Physiological Psychology, AGE, Cognitive dysfunction, PARKINSONS-DISEASE, Neuropsychological tests, TESTS, Speech, PARTICIPANTS, Alzheimer disease

الوصف: Objective To investigate whether automatic analysis of the Semantic Verbal Fluency test (SVF) is reliable and can extract additional information that is of value for identifying neurocognitive disorders. In addition, the associations between the automatically derived speech and linguistic features and other cognitive domains were explored. Method We included 135 participants from the memory clinic of the Maastricht University Medical Center+ (with Subjective Cognitive Decline [SCD; N = 69] and Mild Cognitive Impairment [MCI]/dementia [N = 66]). The SVF task (one minute, category animals) was recorded and processed via a mobile application, and speech and linguistic features were automatically extracted. The diagnostic performance of the automatically derived features was investigated by training machine learning classifiers to differentiate SCD and MCI/dementia participants. Results The intraclass correlation for interrater reliability between the clinical total score (golden standard) and automatically derived total word count was 0.84. The full model including the total word count and the automatically derived speech and linguistic features had an Area Under the Curve (AUC) of 0.85 for differentiating between people with SCD and MCI/dementia. The model with total word count only and the model with total word count corrected for age showed an AUC of 0.75 and 0.81, respectively. Semantic switching correlated moderately with memory as well as executive functioning. Conclusion The one-minute SVF task with automatically derived speech and linguistic features was as reliable as the manual scoring and differentiated well between SCD and MCI/dementia. This can be considered as a valuable addition in the screening of neurocognitive disorders and in clinical practice.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449c9b2306b9d3201b0e91f334358209Test
https://doi.org/10.1093/arclin/acac105Test

المؤلفون: Ebru Baykara, Nicklas Linz, Johannes Tröger, Caroline Kuhn, Julia Karbach

المصدر: The European journal of neuroscienceREFERENCES. 55(2)

مصطلحات موضوعية: Adult, Elementary cognitive task, Modality (human–computer interaction), Modalities, Trail Making Test, medicine.diagnostic_test, Working memory, Computer science, General Neuroscience, Neuropsychology, Flexibility (personality), Neuropsychological Tests, Memory, Short-Term, Human–computer interaction, medicine, Humans, Neuropsychological assessment

الوصف: Using digital technology for neuropsychological assessment is gaining popularity in both clinical and research settings. Digital neuropsychology offers many benefits over the traditional paper-pencil assessments; however, their comparability requires further validation. The aim of this study was to compare a digital, tablet-based Trail Making Test to the standard paper version. In a within-subject design, 108 healthy adults completed both digital and paper Trail Making Test in a counterbalanced order. Each participant also performed other tasks measuring core executive abilities (inhibition, working memory, and flexibility) on the tablet. Our findings indicated that the Trail Making Test performance on the two different modalities correlated significantly. Furthermore, correlations of Trail Making Test performance with other cognitive tasks revealed that digital Trail Making Test is comparable with the paper version. However, the modality had a significant effect on Trail Making Test performance; that is, participants were generally faster on the digital platform. Taken together, our findings suggest that with new normative data, traditional Trail Making Test can be adapted successfully to a digital platform.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09a584f62491cbb633fd84ea814d78fTest
https://pubmed.ncbi.nlm.nih.gov/34811827Test

المؤلفون: Jessica Peter, Nicklas Linz, Johannes Tröger, Hali Lindsay, Jutta Kray, Mario Magued Mina, Stefan Klöppel

مصطلحات موضوعية: medicine.medical_specialty, Neuropsychological Tests, Audiology, behavioral disciplines and activities, 050105 experimental psychology, Task (project management), Executive Function, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Semantic memory, Verbal fluency test, Cognitive Dysfunction, 0501 psychology and cognitive sciences, In patient, Latency (engineering), Control (linguistics), Set (psychology), Point (typography), General Neuroscience, 05 social sciences, Semantics, Psychiatry and Mental health, Clinical Psychology, 150 Psychologie, Neurology (clinical), Psychology, 610 Medizin und Gesundheit, 030217 neurology & neurosurgery

الوصف: Objective:Semantic verbal fluency (SVF) tasks require individuals to name items from a specified category within a fixed time. An impaired SVF performance is well documented in patients with amnestic Mild Cognitive Impairment (aMCI). The two leading theoretical views suggest either loss of semantic knowledge or impaired executive control to be responsible.Method:We assessed SVF 3 times on 2 consecutive days in 29 healthy controls (HC) and 29 patients with aMCI with the aim to answer the question which of the two views holds true.Results:When doing the task for the first time, patients with aMCI produced fewer and more common words with a shorter mean response latency. When tested repeatedly, only healthy volunteers increased performance. Likewise, only the performance of HC indicated two distinct retrieval processes: a prompt retrieval of readily available items at the beginning of the task and an active search through semantic space towards the end. With repeated assessment, the pool of readily available items became larger in HC, but not patients with aMCI.Conclusion:The production of fewer and more common words in aMCI points to a smaller search set and supports the loss of semantic knowledge view. The failure to improve performance as well as the lack of distinct retrieval processes point to an additional impairment in executive control. Our data did not clearly favour one theoretical view over the other, but rather indicates that the impairment of patients with aMCI in SVF is due to a combination of both.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ce4e29fbe653cb195d5c036779cfb4Test

المؤلفون: Jan Alexandersson, Johannes Tröger, Jutta Kray, Philippe Robert, Alexandra König, Nicklas Linz, Jessica Peter

المساهمون: Deutsches Forschungszentrum für Künstliche Intelligenz GmbH = German Research Center for Artificial Intelligence (DFKI), Cognition Behaviour Technology (CobTek), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice), Spatio-Temporal Activity Recognition Systems (STARS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Psychiatric University Clinic [Bern] (UPD), Faculty of Medicine [Bern], University of Bern-University of Bern, Saarland University [Saarbrücken], This research was partially funded by the EIT Digital WellbeingActivity 17074, ELEMENT. The data was partially collected during theEU FP7 Dem@Care project, grant agreement 288199. The authors liketo thank Hali Lindsay and Katja Häuser for helpful feedback on anearlier version of the manuscript., Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice)-Université Côte d'Azur (UCA)

المصدر: Neuropsychologia
Neuropsychologia, Elsevier, 2019, 131, pp.53-61. ⟨10.1016/j.neuropsychologia.2019.05.007⟩
Neuropsychologia, 2019, 131, pp.53-61. ⟨10.1016/j.neuropsychologia.2019.05.007⟩

مصطلحات موضوعية: Male, Cognitive Neuroscience, Semantic analysis (machine learning), Experimental and Cognitive Psychology, Disease, Semantic speech analysis, Neuropsychological Tests, MCI (mild cognitive impairment), 050105 experimental psychology, Speech Disorders, 03 medical and health sciences, Behavioral Neuroscience, [SCCO]Cognitive science, 0302 clinical medicine, Qualitative analysis, Alzheimer Disease, medicine, Semantic memory, Dementia, Verbal fluency test, Humans, Speech, 0501 psychology and cognitive sciences, Control (linguistics), Aged, Aged, 80 and over, 05 social sciences, Alzheimer's disease, Temporal analysis, medicine.disease, Clinical Practice, Female, Psychology, 030217 neurology & neurosurgery, Cognitive psychology

الوصف: International audience; Contents lists available atScienceDirectNeuropsychologiajournal homepage:www.elsevier.com/locate/neuropsychologiaExploitation vs. exploration—computational temporal and semantic analysisexplains semantic verbalfluency impairment in Alzheimer's diseaseJohannes Trögera,∗, Nicklas Linza, Alexandra Königb, Philippe Robertb, Jan Alexanderssona,Jessica Peterc, Jutta KraydaGerman Research Center for Artificial Intelligence (DFKI), GermanybMemory Center, CoBTeK, IA CHU Université Côte d’Azur, FrancecUniversity Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, SwitzerlanddChair for Development of Language, Learning & Action, University of Saarland, GermanyARTICLE INFOKeywords:Alzheimer's diseaseMCI (mild cognitive impairment)Semantic speech analysisTemporal analysisABSTRACTImpaired Semantic Verbal Fluency (SVF) in dementia due to Alzheimer's Disease (AD) and its precursor MildCognitive Impairment (MCI) is well known. Yet, it remains open whether this impairment mirrors the break-down of semantic memory retrieval processes or executive control processes. Therefore, qualitative analysis ofthe SVF has been proposed but is limited in terms of methodology and feasibility in clinical practice.Consequently, research draws no conclusive picture which of these afore-mentioned processes drives the SVFimpairment in AD and MCI. This study uses a qualitative computational approach—combining temporal andsemantic information—to investigate exploitation and exploration patterns as indicators for semantic memoryretrieval and executive control processes. Audio SVF recordings of 20 controls (C, 66–81 years), 55 MCI (57–94years) and 20 AD subjects (66–82 years) were assessed while groups were matched according to age and edu-cation. All groups produced, on average, the same amount of semantically related items in rapid successionwithin word clusters. Conversely, towards AD, there was a clear decline in semantic as well as temporal ex-ploration patterns between clusters. Results strongly point towards preserved exploitation—semantic memoryretrieval processes—and hampered exploration—executive control processes—in AD and potentially in MCI.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94614d2fe916c6cf12bab8784723924Test