التفاصيل البيبلوغرافية
| العنوان: |
Convergent brain microstructure across multiple genetic models of schizophrenia and autism spectrum disorder: A feasibility study. |
| المؤلفون: |
Barnett, Brian R.1 (AUTHOR), Casey, Cameron P.1 (AUTHOR), Torres-Velázquez, Maribel2 (AUTHOR), Rowley, Paul A.3 (AUTHOR), Yu, John-Paul J.1,2,3,4 (AUTHOR) jpyu@uwhealth.org |
| المصدر: |
Magnetic Resonance Imaging (0730725X). Jul2020, Vol. 70, p36-42. 7p. |
| مصطلحات موضوعية: |
*GENETIC models, *AUTISM spectrum disorders, *DIFFUSION tensor imaging, *FEASIBILITY studies, *MENTAL illness, *NEUROMYELITIS optica |
| مستخلص: |
Neuroimaging studies of psychiatric illness have revealed a broad spectrum of structural and functional perturbations that have been attributed in part to the complex genetic heterogeneity underpinning these disorders. These perturbations have been identified in both preclinical genetic models and in patients when compared to control populations, but recent work has also demonstrated strong evidence for genetic, molecular, and structural convergence of several psychiatric diseases. We explored potential similarities in neural microstructure in preclinical genetic models of ASD (Fmr1 , Nrxn1 , Pten) and schizophrenia (Disc1 svΔ2) and in age- and sex-matched control animals with diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI). Our findings demonstrate a convergence in brain microstructure across these four genetic models with both tract-based and region-of-interest based analyses, which continues to buttress an emerging understanding of converging neural microstructure in psychiatric disease. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
