-
1دورية أكاديمية
المؤلفون: Alnakhli, Sultan H., Wand, Handan, Law, Matthew, Sarros, Shannon, Stehmann, Christiane, Senesi, Matteo, Klug, Genevieve M., Simpson, Marion, Lewis, Victoria, Masters, Colin L., Collins, Steven J.
المصدر: Journal of Clinical Neuroscience ; volume 81, page 447 ; ISSN 0967-5868
مصطلحات موضوعية: Physiology (medical), Neurology (clinical), Neurology, General Medicine, Surgery
الإتاحة: https://doi.org/10.1016/j.jocn.2020.10.026Test
https://api.elsevier.com/content/article/PII:S096758682031585X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S096758682031585X?httpAccept=text/plainTest -
2دورية أكاديمية
المؤلفون: Alnakhli, Sultan H., Wand, Handan, Law, Matthew, Sarros, Shannon, Stehmann, Christiane, Senesi, Matteo, Klug, Genevieve M., Simpson, Marion, Lewis, Victoria, Masters, Colin L., Collins, Steven J.
المساهمون: Department of Health, AIHW, University of Melbourne, NHMRC
المصدر: Journal of Clinical Neuroscience ; volume 81, page 78-82 ; ISSN 0967-5868
مصطلحات موضوعية: Physiology (medical), Neurology (clinical), Neurology, General Medicine, Surgery
الإتاحة: https://doi.org/10.1016/j.jocn.2020.09.021Test
https://api.elsevier.com/content/article/PII:S0967586820314983?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0967586820314983?httpAccept=text/plainTest -
3
المؤلفون: Carey Leeanne, Simpson Marion, Churilov Leonid, Heriot Elise, Macdonell Richard, Dimovitis Joanne, Bardsley Belinda
المصدر: Multiple sclerosis and related disorders. 40
مصطلحات موضوعية: Adult, Male, Visual acuity, Multiple Sclerosis, medicine.medical_treatment, Vision Disorders, Context (language use), Placebo, Upper Extremity, 03 medical and health sciences, Grip strength, 0302 clinical medicine, Double-Blind Method, Outcome Assessment, Health Care, medicine, Potassium Channel Blockers, Humans, 030212 general & internal medicine, 4-Aminopyridine, Fatigue, business.industry, Multiple sclerosis, General Medicine, Middle Aged, medicine.disease, Electrophysiological Phenomena, Transcranial magnetic stimulation, Clinical trial, medicine.anatomical_structure, Neurology, Anesthesia, Upper limb, Female, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
الوصف: Background Modified-release 4-aminopyridine (fampridine-MR) is used in the symptomatic treatment of walking disability in patients with multiple sclerosis (MS). Its potential for use in other MS symptoms remains unproven and its mode of action in this context is uncertain. Interest is growing in the use of upper limb outcome measures in clinical trials in patients with Multiple Sclerosis, particularly in advanced or progressive disease. This study tests the following hypotheses: (1) Fampridine-MR improves upper limb function in patients with MS and upper limb impairment. (2) Treatment with fampridine-MR is associated with measurable alterations in objective electrophysiological parameters (evoked potentials and transcranial magnetic stimulation (TMS)) which may predict response to drug treatment. Methods Study population: patients with MS of any disease subtype, duration and severity who have symptomatic impairment of one or both upper limbs. A healthy control group was included for validation of clinical and electrophysiological measures. Study design: randomised double blind placebo-controlled trial. Treatment details: participants allocated to either fampridine-MR 10 mg bd or placebo of identical appearance for 8 weeks. Primary outcome: performance on 9-hole peg test (9HPT) after 4 weeks. Secondary outcomes: persistence of effect on 9HPT; grip strength; visual acuity and contrast sensitivity; modified fatigue impact scale score; sensory discrimination capacity; visual, somatosensory and motor evoked potentials; resting motor threshold; paired-pulse TMS; peripheral nerve conduction studies. Results 40 patients with MS (60% female, median age 52, median disease duration 13.5 years, median EDSS 6.0) were enrolled. Treatment with fampridine-MR was not associated with any change in upper limb function as measured by the clinical primary or secondary outcomes. Treatment with fampridine-MR was also not associated with any difference in electrophysiological measures of upper limb function. This held true after adjustment for hand dominance, disease duration and severity. Four patients withdrew from the trial because of lack of efficacy or side-effects; all were in the placebo arm. Three patients were admitted to hospital during the study period; one with MS exacerbation (placebo group), one with syncope (drug group) and one with UTI (drug group); otherwise there were no serious adverse events. Conclusion Treatment with fampridine-MR was well-tolerated but did not produce clinical benefit in terms of upper limb function, vision or fatigue, nor was there any measurable effect on objective electrophysiological parameters.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33dbba46d59e7dde60c66b41393378d8Test
https://pubmed.ncbi.nlm.nih.gov/32062444Test -
4دورية أكاديمية
المؤلفون: Simpson, Marion, Dimovitis, Joanne, Heriot, Elise, Bardsley, Belinda, Carey, Leeanne, Yiannikas, Con, Macdonell, Richard
المصدر: Clinical Neurophysiology ; volume 127, issue 3, page e12 ; ISSN 1388-2457
مصطلحات موضوعية: Physiology (medical), Neurology (clinical), Neurology, Sensory Systems
الإتاحة: https://doi.org/10.1016/j.clinph.2015.11.026Test
https://api.elsevier.com/content/article/PII:S1388245715011281?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1388245715011281?httpAccept=text/plainTest -
5دورية أكاديمية
المؤلفون: Simpson, Marion, Macdonell, Richard
المصدر: Multiple Sclerosis and Related Disorders ; volume 4, issue 5, page 430-436 ; ISSN 2211-0348
مصطلحات موضوعية: Neurology (clinical), Neurology, General Medicine
الإتاحة: https://doi.org/10.1016/j.msard.2015.06.014Test
https://api.elsevier.com/content/article/PII:S2211034815000851?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2211034815000851?httpAccept=text/plainTest -
6دورية أكاديمية
المصدر: Journal of Clinical Neuroscience ; volume 21, issue 11, page 2048-2049 ; ISSN 0967-5868
مصطلحات موضوعية: Physiology (medical), Neurology (clinical), Neurology, General Medicine, Surgery
الإتاحة: https://doi.org/10.1016/j.jocn.2014.06.063Test
https://api.elsevier.com/content/article/PII:S096758681400424X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S096758681400424X?httpAccept=text/plainTest -
7دورية أكاديميةCharacterising the uncommon corticobasal syndrome presentation of sporadic Creutzfeldt-Jakob disease
المؤلفون: Lee, Will, Simpson, Marion, Ling, Helen, Mclean, Catriona, Collins, Steven, Williams, David R.
المصدر: Parkinsonism & Related Disorders ; volume 19, issue 1, page 81-85 ; ISSN 1353-8020
مصطلحات موضوعية: Neurology (clinical), Geriatrics and Gerontology, Neurology
الإتاحة: https://doi.org/10.1016/j.parkreldis.2012.07.010Test
https://api.elsevier.com/content/article/PII:S1353802012002933?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1353802012002933?httpAccept=text/plainTest -
8دورية أكاديمية
المؤلفون: Simpson, Marion A., Vinton, Anita, Day, Timothy J.
المصدر: Clinical Neurophysiology ; volume 123, issue 7, page e69 ; ISSN 1388-2457
مصطلحات موضوعية: Physiology (medical), Neurology (clinical), Neurology, Sensory Systems
الإتاحة: https://doi.org/10.1016/j.clinph.2011.11.010Test
https://api.elsevier.com/content/article/PII:S1388245711008054?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1388245711008054?httpAccept=text/plainTest -
9دورية أكاديمية
المؤلفون: Simpson, Marion A., Keston, Peter, Bridges, Alan, Macleod, Malcolm
المصدر: Journal of Clinical Neuroscience ; volume 16, issue 12, page 1682-1683 ; ISSN 0967-5868
مصطلحات موضوعية: Physiology (medical), Neurology (clinical), Neurology, General Medicine, Surgery
الإتاحة: https://doi.org/10.1016/j.jocn.2009.03.040Test
https://api.elsevier.com/content/article/PII:S0967586809003300?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0967586809003300?httpAccept=text/plainTest -
10دورية أكاديمية
المؤلفون: Simpson, Marion A, Leith, J Leanne, Ferrington, Linda, Kelly, Paul A T
المصدر: Journal of Cerebral Blood Flow & Metabolism ; volume 25, issue 1_suppl, page S581-S581 ; ISSN 0271-678X 1559-7016
مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Neurology (clinical), Neurology