المؤلفون: Takeshige-Amano, Haruka, Hatano, Taku, Kamagata, Koji, Andica, Christina, Ogawa, Takashi, Shindo, Atsuhiko, Uchida, Wataru, Sako, Wataru, Saiki, Shinji, Shimo, Yasushi, Oyama, Genko, Umemura, Atsushi, Ito, Masanobu, Hori, Masaaki, Aoki, Shigeki, Hattori, Nobutaka

المصدر: Journal of the Neurological Sciences ; volume 457, page 122883 ; ISSN 0022-510X

مصطلحات موضوعية: Neurology (clinical), Neurology

الإتاحة: https://doi.org/10.1016/j.jns.2024.122883Test
https://api.elsevier.com/content/article/PII:S0022510X24000182?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022510X24000182?httpAccept=text/plainTest

المؤلفون: Fukae, Jiro, Eguchi, Hiroto, Wada, Yoichi, Fuse, Atsuhito, Chishima, Rika, Nakatani, Mitsuyoshi, Nakajima, Asuka, Hattori, Nobutaka, Shimo, Yasushi

المصدر: Frontiers in Neurology ; volume 14 ; ISSN 1664-2295

مصطلحات موضوعية: Neurology (clinical), Neurology

الوصف: Hyperhomocysteinemia is an important risk factor for cerebral infarction. Herein, we report on a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. Magnetic resonance imaging showed a fronto-temporal ischemic lesion due to occlusion of the left middle cerebral artery. Clinical testing and imaging demonstrated that he had hyperhomocysteinemia induced by multiple factors including the C677T polymorphism on 5.10-methylenetetrahydrofolate reductase ( MTHFR ), and multiple vitamin deficiencies. The C677T polymorphism on MTHFR is closely related to hyperhomocysteinemia and folate deficiency in epileptic patients who are taking multiple anti-convulsants. Given hyperhomocysteinemia can independently cause stroke at a young age, physicians should periodically examine plasma homocysteine and serum folic acid levels in epileptic patients who are on long-term regimens of multiple anti-epileptic drugs.

الإتاحة: https://doi.org/10.3389/fneur.2023.1183306Test

المؤلفون: Maeda, Tetsuya, Kimura, Takashi, Sugiyama, Kenichiro, Yamada, Kana, Hiraiwa, Ren, Nishi, Masato, Hattori, Nobutaka, Abe, Takashi, Deguchi, Kentaro, Fujimoto, Kenichi, Hasegawa, Kazuko, Hatsuta, Hiroyuki, Hattori, Tatsuya, Ikebe, Shinichiro, Ishida, Yoshinori, Ishikawa, Mitsunori, Isobe, Chiaki, Ito, Kazunori, Ito, Mizuki, Kaneko, Chikako, Kaneko, Satoshi, Kanzato, Naomi, Kawashima, Noriko, Kitamura, Takeshi, Kitayama, Michio, Kosaka, Satoru, Tetsuya, Maeda, Mochizuki, Hideki, Morimoto, Nobutoshi, Murata, Miho, Naka, Takashi, Negishi, Teruhiko, Nishida, Yoshihiko, Nomoto, Masahiro, Orimo, Satoshi, Saiki, Hidemoto, Sakata, Mayumi, Sato, Akira, Shimo, Yasushi, Suzuki, Keisuke, Takahashi, Ryosuke, Takeda, Atsushi, Tatsuoka, Yoshihisa, Toda, Kazuo, Tomiyama, Masahiko, Toru, Shuta, Tsuboi, Yoshio, Tsujino, Akira

المساهمون: Kyowa Hakko Kirin, Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science

المصدر: Parkinsonism & Related Disorders ; volume 117, page 105907 ; ISSN 1353-8020

مصطلحات موضوعية: Neurology (clinical), Geriatrics and Gerontology, Neurology

الإتاحة: https://doi.org/10.1016/j.parkreldis.2023.105907Test
https://api.elsevier.com/content/article/PII:S1353802023009860?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1353802023009860?httpAccept=text/plainTest

المؤلفون: Mishima, Takayasu, Chiu, Shih-Wei, Saiki, Hidemoto, Yamaguchi, Takuhiro, Shimo, Yasushi, Maeda, Tetsuya, Watanabe, Hirohisa, Kashihara, Kenichi, Nomoto, Masahiro, Hattori, Nobutaka, Tsuboi, Yoshio

المساهمون: Kyowa Hakko Kirin

المصدر: Journal of the Neurological Sciences ; volume 448, page 120619 ; ISSN 0022-510X

مصطلحات موضوعية: Neurology (clinical), Neurology

الإتاحة: https://doi.org/10.1016/j.jns.2023.120619Test
https://api.elsevier.com/content/article/PII:S0022510X23000795?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022510X23000795?httpAccept=text/plainTest

المؤلفون: Igami, Eriko, Fukae, Jiro, Kanazawa, Kazo, Fuse, Atsuhito, Nakajima, Asuka, Eguchi, Hiroto, Hattori, Nobutaka, Shimo, Yasushi

المصدر: Frontiers in Neurology ; volume 13 ; ISSN 1664-2295

مصطلحات موضوعية: Neurology (clinical), Neurology

الوصف: We report two rare cases. One involved acute calcific retropharyngeal tendinitis, an inflammatory condition of the longus colli tendon triggered by the deposition of calcium hydroxyapatite crystals. The other involved crowned dens syndrome, caused by pseudogout of the atlantoaxial junction following deposition of calcium pyrophosphate dehydrate or calcium hydroxyapatite. Although these two diseases involve different mechanisms, the common symptoms of neck pain and fever resemble those of meningitis. Accurate diagnosis can thus be difficult without background knowledge of these conditions. Cerebrospinal fluid examination and cervical computed tomography are useful for distinguishing these pathologies from meningitis.

الإتاحة: https://doi.org/10.3389/fneur.2022.946222Test

المؤلفون: Nakajima, Asuka, Iwamuro, Hirokazu, Tokugawa, Joji, Odo, Masahiko, Shimo, Yasushi

المصدر: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ; volume 50, issue 2, page 322-323 ; ISSN 0317-1671 2057-0155

مصطلحات موضوعية: Neurology (clinical), Neurology, General Medicine

الإتاحة: https://doi.org/10.1017/cjn.2022.4Test
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S031716712200004XTest

المؤلفون: Ogawa, Takashi, Hatano, Taku, Kamagata, Koji, Andica, Christina, Takeshige-Amano, Haruka, Uchida, Wataru, Kamiyama, Daiki, Shimo, Yasushi, Oyama, Genko, Umemura, Atsushi, Iwamuro, Hirokazu, Ito, Masanobu, Hori, Masaaki, Aoki, Shigeki, Hattori, Nobutaka

المساهمون: Japan Agency for Medical Research and Development

المصدر: npj Parkinson's Disease ; volume 7, issue 1 ; ISSN 2373-8057

مصطلحات موضوعية: Cellular and Molecular Neuroscience, Neurology (clinical), Neurology

الوصف: Multiple system atrophy (MSA) is classified into two main types: parkinsonian and cerebellar ataxia with oligodendrogliopathy. We examined microstructural alterations in the white matter and the substantia nigra pars compacta (SNc) of patients with MSA of parkinsonian type (MSA-P) using multishell diffusion magnetic resonance imaging (dMRI) and myelin sensitive imaging techniques. Age- and sex-matched patients with MSA-P ( n = 21, n = 10 first and second cohorts, respectively), Parkinson’s disease patients ( n = 19, 17), and healthy controls ( n = 20, 24) were enrolled. Magnetization transfer saturation imaging (MT-sat) and dMRI were obtained using 3-T MRI. Measurements obtained from diffusion tensor imaging (DTI), free-water elimination DTI, neurite orientation dispersion and density imaging (NODDI), and MT-sat were compared between groups. Tract-based spatial statistics analysis revealed differences in diffuse white matter alterations in the free-water fractional volume, myelin volume fraction, and intracellular volume fraction between the patients with MSA-P and healthy controls, whereas free-water and MT-sat differences were limited to the middle cerebellar peduncle in comparison with those with Parkinson’s disease. Region-of-interest analysis of white matter and SNc revealed significant differences in the middle and inferior cerebellar peduncle, pontine crossing tract, corticospinal tract, and SNc between the MSA-P and healthy controls and/or Parkinson’s disease patients. Our results shed light on alterations to brain microstructure in MSA.

الإتاحة: https://doi.org/10.1038/s41531-021-00236-0Test
https://www.nature.com/articles/s41531-021-00236-0.pdfTest
https://www.nature.com/articles/s41531-021-00236-0Test

المؤلفون: Nakajima, Asuka, Shimo, Yasushi, Fuse, Atsuhito, Tokugawa, Joji, Hishii, Makoto, Iwamuro, Hirokazu, Umemura, Atsushi, Hattori, Nobutaka

المصدر: Frontiers in Human Neuroscience ; volume 15 ; ISSN 1662-5161

مصطلحات موضوعية: Behavioral Neuroscience, Biological Psychiatry, Psychiatry and Mental health, Neurology, Neuropsychology and Physiological Psychology

الوصف: We describe the case of a 51-year-old man with Parkinson's disease (PD) presenting with motor fluctuations, who received bilateral subthalamic deep brain stimulation (DBS) with an adaptive DBS (aDBS) device, Percept™ PC (Medtronic, Inc. , Minneapolis, MN). This device can deliver electrical stimulations based on fluctuations of neural oscillations of the local field potential (LFP) at the target structure. We observed that the LFP fluctuations were less evident inside the hospital than outside, while the stimulation successfully adapted to beta oscillation fluctuations during the aDBS phase without any stimulation-induced side effects. Thus, this new device facilitates condition-dependent stimulation; this new stimulation method is feasible and provides new insights into the pathophysiological mechanisms of PD.

الإتاحة: https://doi.org/10.3389/fnhum.2021.702961Test

المؤلفون: Ogawa, Takashi, Hatano, Taku, Kamagata, Koji, Andica, Christina, Takeshige-Amano, Haruka, Uchida, Wataru, Saito, Yuya, Shimo, Yasushi, Oyama, Genko, Umemura, Atsushi, Iwamuro, Hirokazu, Ito, Masanobu, Hori, Masaaki, Aoki, Shigeki, Hattori, Nobutaka

المصدر: Parkinsonism & Related Disorders ; volume 90, page 8-14 ; ISSN 1353-8020

مصطلحات موضوعية: Neurology (clinical), Geriatrics and Gerontology, Neurology

الإتاحة: https://doi.org/10.1016/j.parkreldis.2021.07.021Test
https://api.elsevier.com/content/article/PII:S1353802021002704?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1353802021002704?httpAccept=text/plainTest

المؤلفون: Shimo, Yasushi, Maeda, Tetsuya, Chiu, Shih-Wei, Yamaguchi, Takuhiro, Kashihara, Kenichi, Tsuboi, Yoshio, Nomoto, Masahiro, Hattori, Nobutaka, Watanabe, Hirohisa, Saiki, Hidemoto

المصدر: Parkinsonism & Related Disorders ; volume 91, page 115-120 ; ISSN 1353-8020

مصطلحات موضوعية: Neurology (clinical), Geriatrics and Gerontology, Neurology

الإتاحة: https://doi.org/10.1016/j.parkreldis.2021.09.015Test
https://api.elsevier.com/content/article/PII:S1353802021003448?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1353802021003448?httpAccept=text/plainTest