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1تقرير
المؤلفون: Saulnier, Tiphaine, Fabbri, Margherita, Goff, Mélanie Le, Helmer, Catherine, Traon, Anne Pavy-Le, Meissner, Wassilios G., Rascol, Olivier, Proust-Lima, Cécile, Foubert-Samier, Alexandra
المساهمون: Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'investigation clinique de Toulouse (CIC 1436), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), NS-Park/FCRIN Network, UMS 015, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Epidémiologie, santé publique et développement, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de neurologie Bordeaux, CHU Bordeaux-Groupe hospitalier Pellegrin, Centre de référence de l’atrophie multisystématisée CHU Toulouse, Pôle Neurosciences CHU Toulouse, Institut des Maladies Neurodégénératives Bordeaux (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Hôpital Pellegrin, Epidémiologie et Biostatistique Bordeaux, ANR-18-CE36-0004,DyMES,Modèles Dynamiques pour les Etudes Epidémiologiques Longitudinales sur les Maladies Chroniques(2018)
المصدر: https://hal.science/hal-04210910Test ; 2023.
مصطلحات موضوعية: Health-related Quality of Life, Neurodegenerative disease, Measurement scale, Item Response Theory, Disease progression, [STAT.AP]Statistics [stat]/Applications [stat.AP], [STAT.ME]Statistics [stat]/Methodology [stat.ME]
الوصف: Health-related quality of life (Hr-QoL) scales provide crucial information on neurodegenerative disease progression, help improving patient care, and constitute a meaningful endpoint for therapeutic research. However, Hr-QoL progression is usually poorly documented, as for multiple system atrophy (MSA), a rare and rapidly progressing alpha-synucleinopathy. This work aimed to describe Hr-QoL progression during the natural course of MSA, explore disparities between patients, and identify informative items using a four-step statistical strategy.We leveraged the data of the French MSA cohort comprising annual assessments with the MSA-QoL questionnaire for more than 500 patients over up to 11 years. The four-step strategy (1) determined the subdimensions of Hr-QoL in MSA; (2) modelled the subdimension trajectories over time, accounting for the risk of death; (3) mapped the sequence of item impairments with disease stages; and (4) identified the most informative items specific to each disease stage.Among the 536 patients included, 50% were women and they were aged on average 65.1 years old at entry. Among them, 63.1% died during the follow-up. Four dimensions were identified. In addition to the original motor, nonmotor, and emotional domains, an oropharyngeal component was highlighted. While the motor and oropharyngeal domains deteriorated rapidly, the nonmotor and emotional aspects were already slightly to moderately impaired at cohort entry and deteriorated slowly over the course of the disease. Impairments were associated with sex, diagnosis subtype, and delay since symptom onset. Except for the emotional domain, each dimension was driven by key identified items.Hr-QoL is a multidimensional concept that deteriorates progressively over the course of MSA and brings essential knowledge for improving patient care. As exemplified with MSA, the thorough description of Hr-QoL using the 4-step original analysis can provide new perspectives on neurodegenerative diseases’ management to ultimately deliver better support ...
العلاقة: info:eu-repo/semantics/altIdentifier/arxiv/2309.13089; hal-04210910; https://hal.science/hal-04210910Test; https://hal.science/hal-04210910/documentTest; https://hal.science/hal-04210910/file/Saulnier_manuscript_MSAQoL.pdfTest; ARXIV: 2309.13089
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2تقرير
المؤلفون: Saulnier, Tiphaine, Fabbri, Margherita, Goff, Mélanie Le, Helmer, Catherine, Traon, Anne Pavy-Le, Meissner, Wassilios G., Rascol, Olivier, Proust-Lima, Cécile, Foubert-Samier, Alexandra
المساهمون: Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'investigation clinique de Toulouse (CIC 1436), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), NS-Park/FCRIN Network, UMS 015, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Epidémiologie, santé publique et développement, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de neurologie Bordeaux, CHU Bordeaux-Groupe hospitalier Pellegrin, Centre de référence de l’atrophie multisystématisée CHU Toulouse, Pôle Neurosciences CHU Toulouse, Institut des Maladies Neurodégénératives Bordeaux (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Hôpital Pellegrin, Epidémiologie et Biostatistique Bordeaux, ANR-18-CE36-0004,DyMES,Modèles Dynamiques pour les Etudes Epidémiologiques Longitudinales sur les Maladies Chroniques(2018)
المصدر: https://hal.science/hal-04210910Test ; 2023.
مصطلحات موضوعية: Health-related Quality of Life, Neurodegenerative disease, Measurement scale, Item Response Theory, Disease progression, [STAT.AP]Statistics [stat]/Applications [stat.AP], [STAT.ME]Statistics [stat]/Methodology [stat.ME]
الوصف: Health-related quality of life (Hr-QoL) scales provide crucial information on neurodegenerative disease progression, help improving patient care, and constitute a meaningful endpoint for therapeutic research. However, Hr-QoL progression is usually poorly documented, as for multiple system atrophy (MSA), a rare and rapidly progressing alpha-synucleinopathy. This work aimed to describe Hr-QoL progression during the natural course of MSA, explore disparities between patients, and identify informative items using a four-step statistical strategy.We leveraged the data of the French MSA cohort comprising annual assessments with the MSA-QoL questionnaire for more than 500 patients over up to 11 years. The four-step strategy (1) determined the subdimensions of Hr-QoL in MSA; (2) modelled the subdimension trajectories over time, accounting for the risk of death; (3) mapped the sequence of item impairments with disease stages; and (4) identified the most informative items specific to each disease stage.Among the 536 patients included, 50% were women and they were aged on average 65.1 years old at entry. Among them, 63.1% died during the follow-up. Four dimensions were identified. In addition to the original motor, nonmotor, and emotional domains, an oropharyngeal component was highlighted. While the motor and oropharyngeal domains deteriorated rapidly, the nonmotor and emotional aspects were already slightly to moderately impaired at cohort entry and deteriorated slowly over the course of the disease. Impairments were associated with sex, diagnosis subtype, and delay since symptom onset. Except for the emotional domain, each dimension was driven by key identified items.Hr-QoL is a multidimensional concept that deteriorates progressively over the course of MSA and brings essential knowledge for improving patient care. As exemplified with MSA, the thorough description of Hr-QoL using the 4-step original analysis can provide new perspectives on neurodegenerative diseases’ management to ultimately deliver better support ...
العلاقة: info:eu-repo/semantics/altIdentifier/arxiv/2309.13089; hal-04210910; https://hal.science/hal-04210910Test; https://hal.science/hal-04210910/documentTest; https://hal.science/hal-04210910/file/Saulnier_manuscript_MSAQoL.pdfTest; ARXIV: 2309.13089
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3تقرير
المؤلفون: Saulnier, Tiphaine, Fabbri, Margherita, Goff, Mélanie Le, Helmer, Catherine, Traon, Anne Pavy-Le, Meissner, Wassilios G., Rascol, Olivier, Proust-Lima, Cécile, Foubert-Samier, Alexandra
المساهمون: Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'investigation clinique de Toulouse (CIC 1436), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), NS-Park/FCRIN Network, UMS 015, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Epidémiologie, santé publique et développement, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de neurologie Bordeaux, CHU Bordeaux-Groupe hospitalier Pellegrin, Centre de référence de l’atrophie multisystématisée CHU Toulouse, Pôle Neurosciences CHU Toulouse, Institut des Maladies Neurodégénératives Bordeaux (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Hôpital Pellegrin, Epidémiologie et Biostatistique Bordeaux, ANR-18-CE36-0004,DyMES,Modèles Dynamiques pour les Etudes Epidémiologiques Longitudinales sur les Maladies Chroniques(2018)
المصدر: https://hal.science/hal-04210910Test ; 2023.
مصطلحات موضوعية: Health-related Quality of Life, Neurodegenerative disease, Measurement scale, Item Response Theory, Disease progression, [STAT.AP]Statistics [stat]/Applications [stat.AP], [STAT.ME]Statistics [stat]/Methodology [stat.ME]
الوصف: Health-related quality of life (Hr-QoL) scales provide crucial information on neurodegenerative disease progression, help improving patient care, and constitute a meaningful endpoint for therapeutic research. However, Hr-QoL progression is usually poorly documented, as for multiple system atrophy (MSA), a rare and rapidly progressing alpha-synucleinopathy. This work aimed to describe Hr-QoL progression during the natural course of MSA, explore disparities between patients, and identify informative items using a four-step statistical strategy.We leveraged the data of the French MSA cohort comprising annual assessments with the MSA-QoL questionnaire for more than 500 patients over up to 11 years. The four-step strategy (1) determined the subdimensions of Hr-QoL in MSA; (2) modelled the subdimension trajectories over time, accounting for the risk of death; (3) mapped the sequence of item impairments with disease stages; and (4) identified the most informative items specific to each disease stage.Among the 536 patients included, 50% were women and they were aged on average 65.1 years old at entry. Among them, 63.1% died during the follow-up. Four dimensions were identified. In addition to the original motor, nonmotor, and emotional domains, an oropharyngeal component was highlighted. While the motor and oropharyngeal domains deteriorated rapidly, the nonmotor and emotional aspects were already slightly to moderately impaired at cohort entry and deteriorated slowly over the course of the disease. Impairments were associated with sex, diagnosis subtype, and delay since symptom onset. Except for the emotional domain, each dimension was driven by key identified items.Hr-QoL is a multidimensional concept that deteriorates progressively over the course of MSA and brings essential knowledge for improving patient care. As exemplified with MSA, the thorough description of Hr-QoL using the 4-step original analysis can provide new perspectives on neurodegenerative diseases’ management to ultimately deliver better support ...
العلاقة: info:eu-repo/semantics/altIdentifier/arxiv/2309.13089; hal-04210910; https://hal.science/hal-04210910Test; https://hal.science/hal-04210910/documentTest; https://hal.science/hal-04210910/file/Saulnier_manuscript_MSAQoL.pdfTest; ARXIV: 2309.13089
