التفاصيل البيبلوغرافية
| العنوان: |
A novel NMDA receptor test model based on hiPSC-derived neural cells. |
| المؤلفون: |
Disse, Paul1,2 (AUTHOR) paul.disse@uni-muenster.de, Aymanns, Isabel1 (AUTHOR), Ritter, Nadine1,2 (AUTHOR), Peischard, Stefan1 (AUTHOR), Korn, Lisanne3 (AUTHOR), Wiendl, Heinz3 (AUTHOR), Pawlowski, Matthias3 (AUTHOR), Kovac, Stjepana3 (AUTHOR), Meuth, Sven G.4 (AUTHOR), Budde, Thomas5 (AUTHOR), Strutz-Seebohm, Nathalie1 (AUTHOR), Wünsch, Bernhard6 (AUTHOR), Seebohm, Guiscard1 (AUTHOR) |
| المصدر: |
Biological Chemistry. Mar2023, Vol. 404 Issue 4, p267-277. 11p. |
| مصطلحات موضوعية: |
*METHYL aspartate receptors, *NEURAL stem cells, *DRUG addiction, *TEST systems, *HUMAN stem cells |
| مستخلص: |
N-Methyl-D-aspartate receptors (NMDARs) are central for learning and information processing in the brain. Dysfunction of NMDARs can play a key role in the pathogenesis of neurodegeneration and drug addiction. The development of selective NMDAR modulators represents a promising strategy to target these diseases. Among such modulating compounds are ifenprodil and its 3-benzazepine derivatives. Classically, the effects of these NMDAR modulators have been tested by techniques like two-electrode voltage clamp (TEVC), patch clamp, or fluorescence-based assays. However, testing their functional effects in complex human systems requires more advanced approaches. Here, we established a human induced pluripotent stem cell-derived (hiPSC-derived) neural cell system and proved its eligibility as a test system for investigating NMDAR modulators and pharmaceutical effects on human neurons. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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