دورية أكاديمية
The polysaccharides from Yiqi Yangyin complex attenuated mammary gland hyperplasia: Integrating underlying biological mechanisms and network pharmacology
| العنوان: | The polysaccharides from Yiqi Yangyin complex attenuated mammary gland hyperplasia: Integrating underlying biological mechanisms and network pharmacology |
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| المؤلفون: | Qiao, Xifeng, Wang, Bingying, Yuan, Zhengqiang, Yu, Feng, Zhang, Ying, Wang, Yu, Yang, Yiting, Tang, Jian, Jiang, Zhihong, Lin, Li, Zhang, Lanyue, Du, Zhiyun, Zhang, Yongmin |
| المساهمون: | Guangdong University of Technology, Institut Parisien de Chimie Moléculaire (IPCM), Chimie Moléculaire de Paris Centre (FR 2769), École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris Sciences et Lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris Sciences et Lettres (PSL)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 1756-4646. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Yiqi Yangyin complex (YYC), Mammary Gland Hyperplasia (MGH), Sex hormones, Apoptosis, Network pharmacology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology |
| الوصف: | International audience ; Yiqi Yangyin complex (YYC), the homology of medicine and food, is comprised of Polygonati Rhizoma, Lycii Fructus, Codonopsis pilosula, and Rehmanniae Radix. Herein, the YYC polysaccharide treatment effectively attenuated the progression of MGH in a mice MGH model-induced with estrogen and progestogen. YYC significantly relived hormonal disorders by reducing the levels of estrogen receptor α (ERα) and progesterone receptor (PR), and substantially elevated the protein level of BCL2-associated X (Bax) and significantly down-regulated expression of B-cell lymphoma-2 (BCL-2). Finally, the key targets of ERα, PR, Bax and BCL-2 were predicted and significantly enriched on estrogen signaling pathway and apoptosis pathway by network pharmacology. This finding suggests that YYC may influence the sex hormones level through estrogen signaling pathway and then induce apoptosis to balance normal functions of mammary gland. This study thus provided evidences for the potential therapeutic efficacy of YYC on MGH and revealed the correlated regulatory signaling pathways. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03645647; https://hal.sorbonne-universite.fr/hal-03645647Test; https://hal.sorbonne-universite.fr/hal-03645647/documentTest; https://hal.sorbonne-universite.fr/hal-03645647/file/2022,%2088,%20104878%20Journal%20of%20Functional%20Foods.pdfTest |
| DOI: | 10.1016/j.jff.2021.104878 |
| الإتاحة: | https://doi.org/10.1016/j.jff.2021.104878Test https://hal.sorbonne-universite.fr/hal-03645647Test https://hal.sorbonne-universite.fr/hal-03645647/documentTest https://hal.sorbonne-universite.fr/hal-03645647/file/2022,%2088,%20104878%20Journal%20of%20Functional%20Foods.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.ED9EA23F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jff.2021.104878 |
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