دورية أكاديمية
Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes
| العنوان: | Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes |
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| المؤلفون: | Gainullina, Anastasiia, Mogilenko, Denis, Huang, Li-Hao, Todorov, Helena, Narang, Vipin, Kim, Ki-Wook, Yng, Lim Sheau, Kent, Andrew, Jia, Baosen, Seddu, Kumba, Krchma, Karen, Wu, Jun, Crozat, Karine, Tomasello, Elena, Dress, Regine, See, Peter, Scott, Charlotte, Gibbings, Sophie, Bajpai, Geetika, Desai, Jigar, Maier, Barbara, This, Sébastien, Wang, Peter, Aguilar, Stephanie Vargas, Poupel, Lucie, Dussaud, Sébastien, Zhou, Tyng-An, Angeli, Veronique, Blander, J. Magarian, Choi, Kyunghee, Dalod, Marc, Dzhagalov, Ivan, Gautier, Emmanuel, Jakubzick, Claudia, Lavine, Kory, Lionakis, Michail, Paidassi, Helena, Sieweke, Michael, Ginhoux, Florent, Guilliams, Martin, Benoist, Christophe, Merad, Miriam, Randolph, Gwendalyn, Sergushichev, Alexey, Artyomov, Maxim |
| المساهمون: | Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition CHU Pitié Salpêtrière (IHU ICAN), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), ANR-17-CE15-0007,HSCmemory,Exploration de l'existence d'une fonction et d'une mémoire immunitaire au niveau de la Cellules Souche Hématopoïétique.(2017), ANR-18-CE12-0019,Epromoters,Contrôle de la réponse au stress par une nouvelle classe de promoteurs à activité enhancer(2018), European Project: 695093,MacAge |
| المصدر: | ISSN: 2211-1247. |
| بيانات النشر: | HAL CCSD Elsevier Inc |
| سنة النشر: | 2023 |
| المجموعة: | Aix-Marseille Université: HAL |
| مصطلحات موضوعية: | CP: Immunology, CP: Metabolism, ImmGen, immunometabolism, mononuclear phagocytes, myeloid cells, network analysis, single-cell RNA-seq, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; The diversity of mononuclear phagocyte (MNP) subpopulations across tissues is one of the key physiologicalcharacteristics of the immune system. Here, we focus on understanding the metabolic variability of MNPsthrough metabolic network analysis applied to three large-scale transcriptional datasets: we introduce (1)an ImmGen MNP open-source dataset of 337 samples across 26 tissues; (2) a myeloid subset of ImmGenPhase I dataset (202 MNP samples); and (3) a myeloid mouse single-cell RNA sequencing (scRNA-seq) data-set (51,364 cells) assembled based on Tabula Muris Senis. To analyze such large-scale datasets, we developa network-based computational approach, genes and metabolites (GAM) clustering, for unbiased identifica-tion of the key metabolic subnetworks based on transcriptional profiles. We define 9 metabolic subnetworksthat encapsulate the metabolic differences within MNP from 38 different tissues. Obtained modules revealthat cholesterol synthesis appears particularly active within the migratory dendritic cells, while glutathionesynthesis is essential for cysteinyl leukotriene production by peritoneal and lung macrophages. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36708514; info:eu-repo/grantAgreement//695093/EU/Horizon 2020 research and innovation program/MacAge; hal-04040831; https://hal.science/hal-04040831Test; https://hal.science/hal-04040831/documentTest; https://hal.science/hal-04040831/file/PIIS2211124723000578.pdfTest; PUBMED: 36708514 |
| DOI: | 10.1016/j.celrep.2023.112046 |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2023.112046Test https://hal.science/hal-04040831Test https://hal.science/hal-04040831/documentTest https://hal.science/hal-04040831/file/PIIS2211124723000578.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-ndTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CC0A863A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2023.112046 |
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