نتائج البحث - "Dorsolateral Prefrontal Cortex"

1

Cortico-Brainstem Mechanisms of Biased Perceptual Decision-Making in the Context of Pain

المؤلفون: Jonas Zaman, Irene Tracey, Joachim Vandekerckhove, Francis Tuerlinckx, Katerina Placek, Johan W.S. Vlaeyen, Katja Wiech, Falk Eippert

المساهمون: Section Experimental Health Psychology, RS: FPN CPS I

المصدر: bioXriv
The Journal of Pain, 23(4), 680-692. Churchill Livingstone
The Journal of Pain

مصطلحات موضوعية: bias, PREDICTION, media_common.quotation_subject, DORSOLATERAL PREFRONTAL CORTEX, Pain, Context (language use), Stimulus (physiology), FEAR, Amygdala, Periaqueductal gray, Midbrain, 03 medical and health sciences, 0302 clinical medicine, CONNECTIVITY, Perception, Noxious stimulus, Medicine, Humans, MODULATION, prefrontal, Sensory cue, HUMAN PARIETAL OPERCULUM, media_common, 030304 developmental biology, Pain Measurement, 0303 health sciences, medicine.diagnostic_test, PLACEBO, business.industry, amygdala, Magnetic Resonance Imaging, Dorsolateral prefrontal cortex, Perceptual decision-making, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Neurology, nervous system, EXPECTATION, FMRI, periaqueductal gray, Brainstem, Neurology (clinical), Cues, Psychology, business, Functional magnetic resonance imaging, Neuroscience, 030217 neurology & neurosurgery, Brain Stem

الوصف: Prior expectations can bias how we perceive pain. Using a drift diffusion model, we recently showed that this influence is primarily based on changes in perceptual decision-making (indexed as shift in starting point). Only during unexpected application of high-intensity noxious stimuli, altered information processing (indexed as increase in drift rate) explained the expectancy effect on pain processing. Here, we employed functional magnetic resonance imaging to investigate the neural basis of both these processes in healthy volunteers. On each trial, visual cues induced the expectation of high- or low-intensity noxious stimulation or signaled equal probability for both intensities. Participants categorized a subsequently applied electrical stimulus as either low- or high-intensity pain. A shift in starting point towards high pain correlated negatively with right dorsolateral prefrontal cortex activity during cue presentation underscoring its proposed role of "keeping pain out of mind". This anticipatory right dorsolateral prefrontal cortex signal increase was positively correlated with periaqueductal gray (PAG) activity when the expected high-intensity stimulation was applied. A drift rate increase during unexpected high-intensity pain was reflected in amygdala engagement and increased functional connectivity between amygdala and PAG. Our findings suggest involvement of the PAG in both decision-making bias and altered information processing to implement expectancy effects on pain. PERSPECTIVE: Modulation of pain through expectations has been linked to changes in perceptual decision-making and altered processing of afferent information. Our results suggest involvement of the dorsolateral prefrontal cortex, amygdala, and periaqueductal gray in these processes.

وصف الملف: application/pdf; Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfb9fa42038dbe58d24ac44d622ea0dTest
https://doi.org/10.1016/j.jpain.2021.11.006Test

2

Subregions of DLPFC Display Graded yet Distinct Structural and Functional Connectivity

المؤلفون: Rebecca L. Jackson, Lambon Ralph M, JeYoung Jung

المساهمون: Jung, JeYoung [0000-0003-3739-7331], Jackson, Rebecca L [0000-0001-5339-0266], Apollo - University of Cambridge Repository

المصدر: The Journal of Neuroscience. 42:3241-3252

مصطلحات موضوعية: Male, tractography, Prefrontal Cortex, Biology, behavioral disciplines and activities, Executive Function, mental disorders, medicine, Humans, structural connectivity, Default mode network, dorsolateral prefrontal cortex, Brain Mapping, medicine.diagnostic_test, Working memory, Functional connectivity, General Neuroscience, functional connectivity, Cognitive flexibility, Limbic lobe, executive functions, Executive functions, Magnetic Resonance Imaging, Dorsolateral prefrontal cortex, Inhibition, Psychological, Memory, Short-Term, medicine.anatomical_structure, nervous system, Female, Functional magnetic resonance imaging, Neuroscience, resting-state fMRI, psychological phenomena and processes

الوصف: The human dorsolateral prefrontal cortex (DLPFC; approximately corresponding to Brodmann areas 9 and 46) has demonstrable roles in diverse executive functions such as working memory, cognitive flexibility, planning, inhibition, and abstract reasoning. However, it remains unclear whether this is the result of one functionally homogeneous region or whether there are functional subdivisions within the DLPFC. Here, we divided the DLPFC into seven areas along rostral-caudal and dorsal-ventral axes anatomically and explored their respective patterns of structural and functional connectivity. In vivo probabilistic tractography (11 females and 13 males) and resting-state functional magnetic resonance imaging (fMRI; 57 females and 21 males) were employed to map out the patterns of connectivity from each DLPFC subregion. Structural connectivity demonstrated graded intraregional connectivity within the DLPFC. The patterns of structural connectivity between the DLPFC subregions and other cortical areas revealed that the dorsal-rostral subregions connections were restricted to other frontal and limbic areas, whereas the ventral-caudal region was widely connected to frontal, parietal, and limbic cortex. Functional connectivity analyses demonstrated that subregions of DLPFC were strongly interconnected to each other. The dorsal subregions were associated with the default mode network (DMN), while middle dorsal-rostral subregions were linked with the multiple demand network (MDN). The ventral-caudal subregion showed increased functional coupling with both DMN and MDN. Our results suggest that the connectivity of the DLPFC may be subdivided along a dorsorostral-ventrocaudal axis with differing (albeit graded) patterns of connectivity reflecting the integrative executive function of the DLPFC.SIGNIFICANCE STATEMENTResearch has shown that the dorsolateral prefrontal cortex (DLPFC) plays a role in various executive functions. By dividing the DLPFC into seven areas along rostral-caudal and dorsal-ventral axes anatomically, we explored their patterns of structural and functional connectivity. The patterns of connectivity within DLPFC subregions demonstrated graded intraregional connectivity. There were distinctive patterns of connectivity with other cortical areas in dorsal-rostral and ventral-caudal DLPFC subregions. Divisions across DLPFC subregions seem to align with their structural and functional connectivity. Our results suggest that DLPFC may be subdivided by the diagonal axis of the dorsal-ventral axis and rostral-caudal axis, supporting the framework of a functional organization along the anterior-posterior axis in the lateral PFC.

وصف الملف: PDF; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad775c52d7d3ac3ca5d1e35f83774eaTest
https://doi.org/10.1523/jneurosci.1216-21.2022Test

3

Stimulation of the dorsolateral prefrontal cortex modulates brain cue reactivity to reward (un)availability

المؤلفون: Damien Brevers, Chris Baeken, Stefanie De Smet, Beatriz Catoira, Sara De Witte, Qinghua He, Pierre Maurage, Laimi Schultze-Steinen, Guillaume Sescousse, Claudia Vila Verde, Claus Vögele, Joël Billieux

المساهمون: UCL - SSH/IPSY - Psychological Sciences Research Institute, Brussels Heritage Lab, Clinical sciences, Brain, Body and Cognition, Neuroprotection & Neuromodulation, Psychiatry, Faculty of Medicine and Pharmacy

المصدر: Cortex; a journal devoted to the study of the nervous system and behavior, Vol. 164, no.1, p. 51-62 (2023)

الوصف: Brain imaging studies have shown that stimulation of the left dorsolateral prefrontal cortex (dlPFC), which plays a pivotal role in high-order cognitive control processes, modulates brain reactivity to reward-related cues. Nevertheless, the impact of contextual factors such as reward availability (the reward that is depicted in the cue exposure task) on such modulation effect remains unclear. Here we tested whether a single session of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the left dlPFC differently impacts brain reactivity to cues signalling either availability or unavailability of a sports betting opportunity. Employing a within-subject design (verum versus sham HF-rTMS) among thirty-two frequent sports bettors, we first observed that, as compared to the sham condition, verum HF-rTMS modulated brain reactivity to game cues prior to being made (un)available for betting, through simultaneous increases (posterior insula and caudate nucleus) and decreases (occipital pole) in brain activation. Second, verum HF-rTMS led to increased ventral striatal activity towards cues available for betting but did not modulate brain response to cues unavailable for betting. Third, exploratory functional connectivity analyses revealed increased negative coupling in the verum condition between the left dlPFC and the right and left superior frontal gyrus toward available and non-available betting cues, respectively. Taken together, these findings demonstrate that transient stimulation of the left dlPFC led to a general modulation in brain activity and functional connectivity in responses to cues, and that this effect is only partly dependent on cues signalling for reward (un)availability.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fbf31b983072217f89fc9a18070f1bTest
https://hdl.handle.net/2078.1/275850Test

4

Fearful facial expressions reduce inhibition levels in the dorsolateral prefrontal cortex in subjects with specific phobia

المؤلفون: Lisa Besting, Friederike Roebruck, Lena Pokorny, Stephan Bender, Tomasz A. Jarczok

المصدر: Depression and Anxiety. 39:26-36

الوصف: Background Specific phobias have the highest prevalence among anxiety disorders. Cognitive control involving the dorsolateral prefrontal cortex (DLPFC) is crucial for coping abilities in anxiety disorders. However, there is little research on the DLPFC in specific phobia. Methods Using transcranial magnetic stimulation (TMS), we investigated the TMS-evoked potential component N100 in the DLPFC at rest and while watching emotional expressions. The TMS-evoked N100 provides a parameter for gamma-aminobutyric acid (GABA)-B-mediated cortical inhibition. Twenty-two drug-free subjects with specific phobia (21 females and 1 male) were compared with 26 control subjects (23 females and 3 males) regarding N100 in the DLPFC at rest and during an emotional 1-back task with fearful, angry, and neutral facial expressions. Results At rest, we found reduced N100 amplitudes in the specific phobia compared with the control group. Furthermore, the specific phobia group showed a further reduction in N100 amplitude when memorizing fearful compared with neutral facial expressions. Conclusion There appears to be a decrease in GABA-B-mediated inhibition in the DLPFC in subjects with a specific phobia at rest. This decrease was more pronounced under emotional activation by exposure to fearful facial expressions, pointing towards additional state effects of emotional processing on inhibitory function in the DLPFC.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f271dbf8dfe4f5fa8c7b07a71a924684Test
https://doi.org/10.1002/da.23217Test

5

Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: Systematic review and meta-analysis of fMRI studies

المؤلفون: Anton Albajes-Eizagirre, Joaquim Radua, Lydia Fortea, Julio Sanjuán, Pau Soldevila-Matías, Aleix Solanes, Gracián García-Martí, Diana Tordesillas-Gutiérrez, Inmaculada Fuentes-Durá, Jose M. Rubio, Dominic Oliver

المصدر: Revista de Psiquiatría y Salud Mental (English Edition). 15:101-116

الوصف: Introduction The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP. Methods Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines. Results Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum. Conclusions While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44081338cc7d3250be1a452c22190d37Test
https://doi.org/10.1016/j.rpsmen.2022.06.004Test

6

Repetitive transcranial magnetic stimulation for neuropathic pain: a randomized multicentre sham-controlled trial

المؤلفون: Charles Quesada, Edwige de Chauvigny, Roland Peyron, Jean-Pascal Lefaucheur, Alaa Mhalla, Frédérique Poindessous-Jazat, Nadine Attal, Samar S. Ayache, Didier Bouhassira, Christophe Fermanian, Julien Nizard

المصدر: Brain. 144:3328-3339

مصطلحات موضوعية: Adult, Male, medicine.medical_treatment, Population, behavioral disciplines and activities, law.invention, Dorsolateral Prefrontal Cortex, Double-Blind Method, Randomized controlled trial, law, mental disorders, Humans, Pain Management, Medicine, Outpatient clinic, Brief Pain Inventory, education, Aged, education.field_of_study, business.industry, Motor Cortex, Repeated measures design, Middle Aged, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, Dorsolateral prefrontal cortex, Treatment Outcome, medicine.anatomical_structure, nervous system, Anesthesia, Neuropathic pain, Neuralgia, Female, Neurology (clinical), business, psychological phenomena and processes

الوصف: Repetitive transcranial magnetic stimulation (rTMS) has been proposed to treat neuropathic pain but the quality of evidence remains low. We aimed to assess the efficacy and safety of neuronavigated rTMS to the primary motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC) in neuropathic pain over 25 weeks. We carried out a randomized double-blind, placebo-controlled trial at four outpatient clinics in France. Patients aged 18–75 years with peripheral neuropathic pain were randomly assigned at a 1:1 ratio to M1 or DLPFC-rTMS and rerandomized at a 2:1 ratio to active or sham-rTMS (10 Hz, 3000 pulses/session, 15 sessions over 22 weeks). Patients and investigators were blind to treatment allocation. The primary end point was the comparison between active M1-rTMS, active DLPCF-rTMS and sham-rTMS for the change over the course of 25 weeks (Group × Time interaction) in average pain intensity (from 0 no pain to 10 maximal pain) on the Brief Pain Inventory, using a mixed model repeated measures analysis in patients who received at least one rTMS session (modified intention-to-treat population). Secondary outcomes included other measures of pain intensity and relief, sensory and affective dimensions of pain, quality of pain, self-reported pain intensity and fatigue (patients diary), Patient and Clinician Global Impression of Change (PGIC, CGIC), quality of life, sleep, mood and catastrophizing. This study is registered with ClinicalTrials.gov NCT02010281. A total of 152 patients were randomized and 149 received treatment (49 for M1; 52 for DLPFC; 48 for sham). M1-rTMS reduced pain intensity versus sham-rTMS (estimate for Group × Session interaction: −0.048 ± 0.02; 95% CI: −0.09 to −0.01; P = 0.01). DLPFC-rTMS was not better than sham (estimate: −0.003 ± 0.01; 95% CI: −0.04 to 0.03, P = 0.9). M1-rRMS, but not DLPFC-rTMS, was also superior to sham-rTMS on pain relief, sensory dimension of pain, self-reported pain intensity and fatigue, PGIC and CGIC. There were no effects on quality of pain, mood, sleep and quality of life as all groups improved similarly over time. Headache was the most common side effect and occurred in 17 (34.7%), 23 (44.2%) and 13 (27.1%) patients from M1, DLPFC and sham groups, respectively (P = 0.2). Our results support the clinical relevance of M1-rTMS, but not of DLPFC-rTMS, for peripheral neuropathic pain with an excellent safety profile.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09eee8cb815c76ee9e249886f758c2f4Test
https://doi.org/10.1093/brain/awab208Test

7

Functional impairment‐based segmentation of anterior cingulate cortex in depression and its relationship with treatment effects

المؤلفون: Xinyi Wang, Cong Pei, Yujie Zhang, Qing Lu, Shuqiang Zhang, Haiyan Liu, Zhilu Chen, Junneng Shao, Zhijian Yao

المصدر: Human Brain Mapping

مصطلحات موضوعية: Male, Functional impairment, computer.software_genre, 0302 clinical medicine, Dorsolateral Prefrontal Cortex, Voxel, Outcome Assessment, Health Care, Medicine, Depression (differential diagnoses), Research Articles, Radiological and Ultrasound Technology, major depressive disorders, 05 social sciences, Middle Aged, Amygdala, Magnetic Resonance Imaging, anterior cingulate cortex, medicine.anatomical_structure, Neurology, Antidepressant, Major depressive disorder, functional MRI, Female, Anatomy, unsupervised machine learning, psychological phenomena and processes, Research Article, Adult, behavioral disciplines and activities, Gyrus Cinguli, 050105 experimental psychology, antidepressive agents, 03 medical and health sciences, Young Adult, mental disorders, Connectome, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Anterior cingulate cortex, Depressive Disorder, Major, Resting state fMRI, business.industry, segmentation, medicine.disease, Dorsolateral prefrontal cortex, nervous system, Neurology (clinical), business, Neuroscience, computer, 030217 neurology & neurosurgery

الوصف: In major depressive disorder (MDD), the anterior cingulate cortex (ACC) is widely related to depression impairment and antidepressant treatment response. The multiplicity of ACC subdivisions calls for a fine‐grained investigation of their functional impairment and recovery profiles. We recorded resting state fMRI signals from 59 MDD patients twice before and after 12‐week antidepressant treatment, as well as 59 healthy controls (HCs). With functional connectivity (FC) between each ACC voxel and four regions of interests (bilateral dorsolateral prefrontal cortex [DLPFC] and amygdalae), subdivisions with variable impairment were identified based on groups' dissimilarity values between MDD patients before treatment and HC. The ACC was subdivided into three impairment subdivisions named as MedialACC, DistalACC, and LateralACC according to their dominant locations. Furthermore, the impairment pattern and the recovery pattern were measured based on group statistical analyses. DistalACC impaired more on its FC with left DLPFC, whereas LateralACC showed more serious impairment on its FC with bilateral amygdalae. After treatment, FCs between DistalACC and left DLPFC, and between LateralACC and right amygdala were normalized while impaired FC between LateralACC and left amygdala kept dysfunctional. Subsequently, FC between DistalACC and left DLPFC might contribute to clinical outcome prediction. Our approach could provide an insight into how the ACC was impaired in depression and partly restored after antidepressant treatment, from the perspective of the interaction between ACC subregions and critical frontal and subcortical regions.
This article identified the subregions of the anterior cingulate cortex with variable impairment in major depressive disorder patients and investigated the restoration pattern of subregions after antidepressant treatment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f98da45aed44ae9385c58593ab052e8Test
http://europepmc.org/articles/PMC8288091Test

8

Transcranial magnetic stimulation over the right dorsolateral prefrontal cortex modulates visuospatial distractor suppression

المؤلفون: Ling Li, Ke Xie, Dong-Gang Jin, Xuejin Ni, Zhenlan Jin, Junjun Zhang

المصدر: The European Journal of Neuroscience

مصطلحات موضوعية: genetic structures, medicine.medical_treatment, media_common.quotation_subject, Short Communication, distractor suppression, Prefrontal Cortex, Posner cueing task, behavioral disciplines and activities, Visual processing, 03 medical and health sciences, 0302 clinical medicine, transcranial magnetic stimulation, medicine, Contrast (vision), Humans, Attention, Systems Neuroscience, 030304 developmental biology, media_common, Cued speech, 0303 health sciences, dorsolateral prefrontal cortex, saliency, General Neuroscience, musculoskeletal, neural, and ocular physiology, Attentional control, Transcranial magnetic stimulation, Dorsolateral prefrontal cortex, Inhibition, Psychological, medicine.anatomical_structure, nervous system, Right dorsolateral prefrontal cortex, Cues, Psychology, Neuroscience, 030217 neurology & neurosurgery, psychological phenomena and processes, location

الوصف: Visual selective attention allows us to filter relevant inputs from irrelevant inputs during visual processing. In contrast to rich research exploring how the brain facilitates task‐relevant inputs, less is known about how the brain suppresses irrelevant inputs. In this study, we used transcranial magnetic stimulation (TMS) to investigate the causal role of the right dorsolateral prefrontal cortex (DLPFC), a crucial brain area for attentional control, in distractor suppression. Specifically, 10‐Hz repetitive TMS (rTMS) was applied to the right DLPFC and Vertex at the stimuli onset (stimuli‐onset TMS) or 500 ms prior to the stimuli onset (prestimuli TMS). In a variant of the Posner cueing task, participants were instructed to identify the shape of a white target while ignoring a white or colored distractor whose location was either cued in advance or uncued. As anticipated, either the location cue or the colored distractor led to faster responses. Notably, the location cueing effect was eliminated by stimuli‐onset TMS to the right DLPFC, but not by prestimuli TMS. Further analyses showed that stimuli‐onset TMS quickened responses to uncued trials, and this TMS effect was derived from the inhibition at the distractor in both visual fields. In addition, TMS over the right DLPFC had no specific effect on the colored distractor compared to the white one. Considered collectively, these findings indicate that the DLPFC plays a crucial role in visuospatial distractor suppression and acts upon stimuli presentation. Besides, it seems the DLPFC contributes more to location‐based distractor suppression than to color‐based one.
The location cue or salience of a distractor triggers distractor suppression. Stimuli‐onset DLPFC TMS enhances distractor suppression triggered by location cue only. No prestimuli DLPFC‐TMS effect is found on distractor suppression.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46fc0361c5b3e1c12bda1ad0d9c68f9Test
http://europepmc.org/articles/PMC8252778Test

9

Low-beta repetitive transcranial magnetic stimulation to human dorsolateral prefrontal cortex during object recognition memory sample presentation, at a task-related frequency observed in local field potentials in homologous macaque cortex, impairs subsequent recollection but not familiarity

المؤلفون: Lydia Hickman, Lennart Verhagen, Erica A. Boschin, Matthew Ainsworth, Martina Kavanova, Zhemeng Wu, Carlos Pedreira, Mark J. Buckley, Juan M. Galeazzi

المصدر: European Journal of Neuroscience, 54, 11, pp. 7918-7945
European Journal of Neuroscience, 54, 7918-7945

الوصف: Contains fulltext : 241277.pdf (Publisher’s version ) (Open Access) According to dual-process signal-detection (DPSD) theories, short- and long-term recognition memory draws upon both familiarity and recollection. It remains unclear how primate prefrontal cortex (PFC) contributes to these processes, but frequency-specific neuronal activities are considered to play a key role. In Experiment 1, nonhuman primate (NHP) local field potential (LFP) electrophysiological recordings in macaque left dorsolateral PFC (dlPFC) revealed performance-related differences in a low-beta frequency range during the sample presentation phase of a visual object recognition memory task. Experiment 2 employed a similar task in humans and targeted left dlPFC (and vertex as a control) with repetitive transcranial magnetic stimulation (rTMS) at 12.5 Hz during occasional sample presentations. This low-beta frequency rTMS to dlPFC decreased DPSD derived indices of recollection, but not familiarity, in subsequent memory tests of the targeted samples after short delays. The same number of rTMS pulses over the same total duration albeit at a random frequency had no effect on either recollection or familiarity. Neither stimulation protocols had any causal effect upon behaviour when targeted to the control site (vertex). In this study, our hypotheses for our human TMS study were derived from our observations in NHPs; this approach might inspire further translational research through investigation of homologous brain regions and tasks across species using similar neuroscientific methodologies to advance the neural mechanism of recognition memory in primates. 28 p.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bddcaa523079ccbb95f17c8f11932aeTest
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/241277Test

10

A novel approach for targeting the left dorsolateral prefrontal cortex for transcranial magnetic stimulation using a cognitive task

المؤلفون: Adriano H. Moffa, Colleen Loo, Stevan Nikolin, Ashley Wang, Donel Martin

المصدر: Experimental Brain Research. 240:71-80

الوصف: Repetitive transcranial magnetic stimulation (rTMS) has the potential to be developed as a novel treatment for cognitive dysfunction. However, current methods of targeting rTMS for cognition fail to consider inter-individual functional variability. This study explored the use of a cognitive task to individualise the target site for rTMS administered to the left dorsolateral prefrontal cortex (L-DLPFC). Twenty-five healthy participants were enrolled in a sham-controlled, crossover study. Participants performed a random letter generation task under the following conditions: no stimulation, sham and active ‘online’ rTMS applied to F3 (International 10–20 System) and four standardised surrounding sites. Across all sites combined, active ‘online’ rTMS was associated with significantly reduced performance compared to sham rTMS for unique trigrams (p = 0.012), but not for unique digrams (p > 0.05). Using a novel localisation methodology based on performance outcomes from both measures, a single optimal individualised site was identified for 92% [n = 23] of participants. At the individualised site, performance was significantly poorer compared to a common standard site (F3) and both control conditions (ps

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0eaac3ee519cdd8a8d1674c7d63af303Test
https://doi.org/10.1007/s00221-021-06233-2Test

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