التفاصيل البيبلوغرافية
| العنوان: |
Repeated greater occipital nerve injections with corticosteroids in medically intractable chronic cluster headache: a retrospective study. |
| المؤلفون: |
Brandt, Roemer B.1 (AUTHOR) r.b.brandt@lumc.nl, Doesborg, Patty G. G.1 (AUTHOR), Meilof, Roy1 (AUTHOR), de Coo, Ilse F.1 (AUTHOR), Bartels, Eveline2 (AUTHOR), Ferrari, Michel D.1 (AUTHOR), Fronczek, Rolf1 (AUTHOR) |
| المصدر: |
Neurological Sciences. Feb2022, Vol. 43 Issue 2, p1267-1272. 6p. 2 Charts. |
| مستخلص: |
Introduction: Current prophylactic drugs for cluster headache are associated with limited efficacy, serious side effects and poor tolerability. Greater occipital nerve injection (GON-injection) has been proven effective and safe as a single, one-time injection in episodic (ECH), and to a lesser extent, chronic cluster headache (CCH). We aim to analyse the effectiveness and safety of repeated GON-injections in medically intractable chronic cluster headache (MICCH). Methods: Clinical data of all cluster headache patients who had received at least one GON-injection between 2014 and 2018 in our tertiary headache centre were retrieved from patients' medical records. Clinical history was taken as part of routine care shortly before and 6 weeks after GON-injection. Results: We identified 47 MICCH patients (79 injections), and compared results with 22 non-MI CCH patients (30 injections) and 50 ECH patients (63 injections). Nineteen MICCH patients received repeated injections (32 in total, range 2–8). Rates of clinical relevant improvement to a first injection were similar in all groups (MICCH: 60%, non-MICCH 73%, ECH 76%; attack freedom: MICCH: 30%, non-MICCH 32%, ECH 43%). Furthermore, no difference in response to the first and second injection was shown between groups (all p > 0.29). Median effect duration in MICCH was 6 weeks (IQR 2.8–12 weeks). Side effects were only mild and local. Conclusion: In this retrospective analysis, first and repeated GON-injections were well-tolerated and equally effective in MICCH as in non-MICCH, and ECH. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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